Assistant Professor, Biosciene & Biomedical Engineering, Hong Kong University of Science and Technology (Guangzhou) | Neuronal RNA metabolism
Guangzhou, China
Joined September 2018
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Huge congratulations to Christine! Very well-deserved recognition for her truly courageous and innovative research on axon guidance and local translation, and for being an inspiring mentor to the younger generation of neuroscience lovers!
Congratulations to The Brain Prize winners of 2023: Professors Michael Greenberg, Christine Holt and @erin_schuman.
They have done pioneering work on molecular mechanisms of brain development and plasticity
Read: lundbeckfonden.com/en/pionee…
#TheBrainPrize #BrainPrize23 #neuroscience
Julie Qiaojin Lin retweeted
Finally out!
We found that mRNAs are not uniformly distributed across the cytoplasm.
mRNA architecture is the strongest determinant for localization.
Subcytoplasmic location of translation controls protein output.
cell.com/molecular-cell/full…
Julie Qiaojin Lin retweeted
Looking for an exciting postdoctoral position? Have skills or interest in rodent neurophys, opto, olfaction and sleep? Want to live in London and work at the amazing @SWC_Neuro? DM me and let’s chat at #SfN2023!
sainsburywellcome.org/web/co…
Julie Qiaojin Lin retweeted
What is the link between hibernation and neurodegeneration? How could a cold-resistance protein pave the way for new dementia treatments?
The UK DRI's @JulieQLin & @DeepakKhuperkar spoke to @OpenTargets about their research into a key protein, RBM3⬇️
blog.opentargets.org/rbm3-re…
Julie Qiaojin Lin retweeted
What is the link between hibernation and dementia treatments?
This is the question that @JulieQLin and @DeepakKhuperkar try to answer in their latest project — we chatted to them to find out more
blog.opentargets.org/rbm3-re…
Julie Qiaojin Lin retweeted
#HNRNPH1 regulates expression of the #neuroprotective cold-shock protein #RBM3 through poison exon exclusion
@JulieQLin @DeepakKhuperkar et al @MallucciLab @RueppLab
embopress.org/doi/full/10.15…
Julie Qiaojin Lin retweeted
Christine Holt, 2023 Brain Prize winner giving her Prize Lecture: Brain wiring and local translation in axons.
Introduced by Richard Morris, Chair of The Brain Prize selection committee.
#BrainPrize #neuroscience #science – at Capital Region, Denmark
Julie Qiaojin Lin retweeted
Happy to share the first paper from our @UKDRI Cross-Centre project with @MallucciLab in collaboration with @ule_lab and Metzakopian lab led by the amazing @JulieQLin and @DeepakKhuperkar. embopress.org/doi/full/10.15….
Julie Qiaojin Lin retweeted
🚨 Hot off the press!
A @UKDRI analysis of an Open Targets screen delves into the regulation of the RBM3 cold-shock protein, identifying HNRNPH1 as a potential neuroprotective target
Congratulations to first authors @JulieQLin and @DeepakKhuperkar!
ALT Text reads: NHRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion. Julie Giaojin Lin, Deepak Khuperkar et al, 2023. The EMBO journal. This is illustrated with ice crystals formed of cartoon neurons. The Open Targets logo features on the bottom left of the image.
Julie Qiaojin Lin retweeted
Interested in understanding how neurons transport mRNAs in dendrites and control when and where they're used for local protein synthesis? My group is hiring a postdoctoral researcher!
elxw.fa.em3.oraclecloud.com/…
Julie Qiaojin Lin retweeted
Scientists at the UK DRI at Cambridge have used gene therapy to increase levels of ‘cold shock protein’ in the brains of mice, protecting them against prion disease.
If we could replicate this in humans, it could be a way to prevent neurodegeneration👉buff.ly/3ns4kwf
Julie Qiaojin Lin retweeted
I am very excited and looking forward to start my own research team @FGA_lab @VUamsterdam soon to study neuronal mRNA trafficking and axonal translation.
I am looking for a PhD candidate to strengthen this team so get in touch if you are interested!
workingat.vu.nl/ad/phd-candi…
Julie Qiaojin Lin retweeted
mRNA transport, translation, and decay in adult mammalian central nervous system axons cell.com/neuron/fulltext/S08…
Julie Qiaojin Lin retweeted
Do you want to learn more about the axonal endoplasmic reticulum and about local translation? Have a look at our new preprint! biorxiv.org/content/10.1101/…. @UniUtrecht @ginny_farias Lab. A🧵
Julie Qiaojin Lin retweeted
Can we target alternative splicing to treat neurodegenerative diseases? With @MallucciLab and @OmiqaBio we find that a poison exon is responsible for cold induced RBM3 expression. Targeting this exon by ASO-therapy results in neuroprotection in vivo. biorxiv.org/content/10.1101/…
Ever wonder what happens to our brains at lower temperatures? Looks like our neurons enjoy a cool bath – thanks to increased expression of a cold-shock protein, RBM3. Check out our preprint sharing some secrets behind RBM3 cold induction. biorxiv.org/content/10.1101/…
Now you may have another question: how does RBM3 protect neurons? We will leave this story for another time. Stay tuned!
Meanwhile, also check out another collaborative project between @Malluccilab and Heyd lab @pre_mRCO, for neuroprotection upon RBM3 induction using ASOs. biorxiv.org/content/10.1101/…