A youtube channel exploring biochemistry. https://xitter.cf/t.co/8DE8sGlrVh
Joined April 2020
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⚡NEW VIDEO⚡
🧬How Your DNA Copies Itself
youtu.be/lv89fSt5jBY
Rendered in @bradyajohnston 's beautiful Molecular Nodes.
Works cited thread to follow.
Clockwork retweeted
If there is big biotech announcement happening, #MolecularNodes is being used for it. I only had the realisation in the past day, but it's strange to have my software very quickly become the visual face for $100M announcements and massive scientific breakthroughs.
Every week, I find a new idea to steal from @NikoMcCarty -- I'm about to publishing a video about KaiC's circadian clock reaction based on a great article published in @AsimovPress .
But this is THE best idea to steal. Currently outlining how I could launch this by Q1 2026.
Another YouTube Channel Idea:
"E. coli Design." A whole series where you explain how to design DNA to change the behavior or appearance of E. coli cells. All you'd need is some equipment to transform cells, a microscope and camera, and some basic molecular biology equipment.
Some ideas for modules:
1. The basics of a transcription unit; inserting GFP into cells and watching them glow.
2. Using a base editor to change GFP into another color?
3. Engineering E. coli to spin around in circles.
4. Engineering E. coli to swim faster, or to grow larger, or to partition their DNA unevenly, etc.
... and then end the series with the repressilator and blinking bacteria or something.
You could inspire tens of thousands of future bioengineers and completely demystify this space. Plus it's so cool to directly show how DNA sequences can lead to physical, observable changes in the cell.
I finally start feeling confident about the work I do--and then the GOAT leaves the game.
I'm very happy to announce that I have retired! I'm equally happy that @janetiwasa has agreed to continue the Molecule of the Month @buildmodels. Read about this at cdn.rcsb.org/rcsb-pdb/genera…
very emotional about this announcement--but also very excited for the @janetiwasa era at the Molecule of the Month. The animation lab is INCREDIBLE. Latest Molecule of the Month an incredible start:
pdb101-beta.rcsb.org/motm/30…
Incredible article and well deserved!
Announced: The PDB Molecule of the Month for December is the flagellar motor! An informative article paired with a beautiful artwork by Dr. David Goodsell. pdb101.rcsb.org/motm/300
@buildmodels @dsgoodsell #Science #Discovery #PDB
This is my favorite Molecule of the Month!
ALT Bacterial flagellar motor in clockwise orientation bound to CheY. Illustrated by Dr. David Goodsell.
Clockwork retweeted
Recognize these heroes of animation?
ANIMATION HEROES, ASSEMBLE!
Join them in fighting for Animation Workers by posting with #StandWithAnimation AND by signing the petition in the reply!
🍂NEW VIDEO🍂
All through Autumn, trees race against time to recycle their chlorophyll--and basically everything else in their leaves.
But why go through all this effort?
The answers are honestly mind-blowing:
rendered in #blender3d using @bradyajohnston's #molecularnodes
Clockwork retweeted
Have you ever wondered how the body can tell between good and bad bacteria? We all know by now that the healthy human microbiome is capable of doing all sorts of amazing things, from regulating how you think and feel, to training and tuning your immune response. (A🧵)
📺WATCH:
@neutralphil continues being top-tier--bridging the gap between cell and molecular biology:
youtube.com/watch?v=iA4As2_O…
Prepare for this to gradually become my entire personality and focus on YouTube.
Hi! My new book, Everything Is Tuberculosis, comes out March 18th. I'm signing 100,000 copies of it. You can preorder your signed copy today at everythingistb.com or wherever books are sold.
👀NEW VIDEO 👀
Meet Rhodopsin, the ancient protein in your retina that physically changes when touched by light. Let's explore this structure and the golden retinal pigment that powers your vision.
Rendered in #Blender3d using @bradyajohnston's Molecular Nodes. #geometrynodes
Full video here: youtu.be/LexKZva0s4I
Further vignettes and structures cited to follow. This one goes pretty far just to explain a few small conformational changes.
This is why I work as hard as I do. Legitimately one of the happiest moments I've had.
Overjoyed the visualization here was actually useful.
Amazing talk from @JohannJRoske at the #LMB lab talks! Thanks to @this_clockwork for bringing the replisome to life 🧬🧬🧬
Oh I’m having the BEST day
The October 2024 issue of The Plant Cell – with a Focus on Photosynthesis -- is now online! @ASPB @OxUniPress buff.ly/3GvIUT4 #PlantSci
ALT Title: FOCUS ON PHOTOSYNTHESIS On the cover: Artistic rendering of the interior of a chloroplast. This crosssection through a chloroplast shows the two-layered membrane at the top (sage green) and the stacked grana below (bright green). The photosynthetic electron transport chain is embedded in the membranes of the grana. Rubisco (represented by the large blue blobs) is found in the soluble space. The illustration emphasizes the distributed workload among the many different chloroplast proteins. This focus issue on photosynthesis includes a commentary on plastid retrograde signaling, a commentary on open questions in photosynthesis research, a perspective on improving photosynthesis, six indepth review articles covering the major protein complexes participating in the photosynthetic light reactions, and a set of eight original research articles. Image credit: David S. Goodsell. doi: 10.2210/rcsb_pdb/goodsell-gallery-010.
Clockwork retweeted
Huge if true!
New Letter: "Rubisco supplies pyruvate for the 2-C-methyl-d-erythritol-4-phosphate pathway" rdcu.be/dVZMj
Rubisco fixes CO2. Its lesser-known side job is supplying pyruvate in the chloroplast, an observation that solves a long-standing paradox of central metabolism.
