@theJensenLab

This is the official Twitter feed of the Jensen Lab @BYU

 Provo, Utah
jensenlab.caltech.edu/
Joined October 2014
  • Tweets208
  • Following770
  • Followers4.1K
121Media
Combining live-cell imaging and cryo-ET of nanotubes in Bacillus subtilis gave us a first look at a novel bacterial organelle: the tubeosome. Check it out here: biorxiv.org/content/10.64898…

Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge

Bacterial nanotubes are widespread intercellular membranous bridges mediating molecular exchange among neighboring cells, yet their formation and dynamics remain largely unexplored. By combining...

biorxiv.org
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Shoutout to Phyllis and her work on human NLRP3 inflammasomes! Great to see this published.
Phyllis Wang@Phyllis23382012Mar 27
A big part of my graduate work has finally made it online. Proof that science loves to surprise us in experiments😎 @theJensenLab Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center | Science Advances science.org/doi/10.1126/scia…

Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing...

Cryo-ET reveals that the NLRP3 inflammasome in human macrophages forms a condensate that disrupts the MTOC.

science.org
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Check out our @JoVEJournal video article with @Phyllis23382012 describing how to use a new tri-coincident fluorescence, electron, and ion beam microscope for targeted milling of cells! Full video & article: hubs.ly/Q047QRRK0 #JoVE #Reproducibility
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Producing lamellae containing small and rare fluorescent targets is getting more efficient: app.jove.com/t/68238/workflo…
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Our lab collaborated with @BYU_Biophysics to create this important tomogram dataset, which will be a useful benchmark for future machine learning developments in the cryo-ET world.
BYU_BiophysicsGroup@BYU_Biophysics29 Apr 2025
Excited to share our paper about MotorBench, the dataset we created for our ongoing #Kaggle competition, posted on BioRxiv: biorxiv.org/content/10.1101/…
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Jensen Lab retweeted
PNCC@CryoEM_PNCC10 Apr 2025
Please join us at #MM2025 for our jointly hosted Pre-Meeting Congress (PMCX61) on Transformative High-Resolution CryoEM! Let's shape the future of microscopy & structural biology research. We look forward to seeing you there. #CryoEM
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Join me at the Structure-Based Drug Design Summit, where I'll be leading a discussion-based workshop on the potential of cryo-ET for structure-based drug design. Learn more here: ter.li/rpnj5g
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Our lab provided tomography data for this exciting competition, which aims to accelerate the cryo-ET workflow. If you're skilled with AI and machine learning development, please participate!
BYU_BiophysicsGroup@BYU_Biophysics6 Mar 2025
Interested in helping solve a machine learning problem for structural biologists (and competing for a cash prize)? Check out our @kaggle competition that launched yesterday: kaggle.com/competitions/byu-… We look forward to seeing your submissions!

BYU - Locating Bacterial Flagellar Motors 2025

Help locate flagellar motors in three-dimensional reconstructions of bacteria.

kaggle.com
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It’s been a while, but we’re getting back up and running at BYU. In case you missed them, here’s a thread with a few of the papers we’ve worked on in the meantime. Congrats to all authors, and full steam ahead!
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doi.org/10.7554/eLife.82891 in @eLife

A cryogenic, coincident fluorescence, electron, and ion beam microscope

Integrating a cryogenic light microscope with a focused ion beam/scanning electron microscope, allows directly targeting of fluorescent structure when preparing a frozen-hydrated lamella, without the...

elifesciences.org
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doi.org/10.1016/j.str.2023.0… in @Structure_CP
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biorxiv.org/content/10.1101/… at @biorxivpreprint

Structure and Function of the Dot/Icm T4SS

The Legionella pneumophila Dot/Icm type IV secretion system (T4SS) delivers effector proteins into host cells during infection. Despite its significance as a potential drug target, our current...

biorxiv.org
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doi.org/10.1038/s41564-023-0… in @NatureMicrobiol
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Check out our new paper in @JStructBiol X on a subtomogram averaging workflow to capture structures and their molecular context: doi.org/10.1016/j.yjsbx.2022… Congrats to @LAMetskas and all authors!
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Our paper with @mikhailshapiro and Michael Ortiz groups on buckling properties of bacterial gas vesicles out now in @BiophysJ: doi.org/10.1016/j.bpj.2022.0… Congrats to (Amir) Hossein Salahshoor, @yuxing_yao, @przemyslawdutka and all authors!
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Check out our new @biorxivpreprint with @DebnathGhosal, @ElitzaTocheva, and Anath Das groups on the structure of the Agrobacterium tumefaciens T-pilus: doi.org/10.1101/2022.09.25.5… Congrats to Stefan Kreida, Akihiro Narita and all authors!
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Check out our new @biorxivpreprint with @DebnathGhosal, Robert Heinzen's groups and others on structural remodeling of Coxiella burnetii during its biphasic developmental cycle: doi.org/10.1101/2022.08.23.5… Congrats to @MohammedKaplan_, @DoulinShepherd and all authors!
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Our paper with @SavageCatsOnly on RuBisCO lattices in α-carboxysomes is out now in @NatureComms: doi.org/10.1038/s41467-022-3… Congrats to @LAMetskas and all authors!
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Check out our collaboration with Anton Zavialov's group and others on the zigzag spring-like structure of an archaic chaperone-usher pilus in @Nature: doi.org/10.1038/s41586-022-0… Congrats to @NPakharuk, Henri Malmi and all authors!
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Our paper with @CLShafferPhD, @sigalby and @IlanRosenshine labs on a novel and widespread bacterial structure related to the type III secretion system is out now in @JBacteriology: doi.org/10.1128/jb.00144-22 Congrats to @MohammedKaplan_ and all authors!
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