PhD molecular biologist with expertise in hematology @CincyChildrens. Outside of lab, I am a father, husband, sports coach, and scout leader. Views are my own.
Cincinnati, OH
Joined July 2008
- Tweets255
- Following153
- Followers270
- Likes978
Tim Chlon retweeted
🚨Apparently all NIH Study Sections have been suspended indefinitely.
For those who don’t know, this means there won’t be any review of grants submitted to NIH
Depending on how long this goes on for, this could lead to an interruption in billions in research funding.
Tim Chlon retweeted
Dr. Emily Stepanchick from the Chlon lab (@tchlon) at @CincyChildrens led this study showing that DDX41 haploinsufficiency causes inefficient #hematopoiesis under stress ⚡ and cooperates with p53 mutations to cause hematologic malignancy.
👉 go.nature.com/3W7WR4C
I am proud to present my lab’s first research paper, published online in @LeukemiaJnl today! Check it out rdcu.be/dL6vp
Congrats to first author Emily Stepanchick!
Mechanistically, we find that Ddx41-het progenitor cells have activated cellular stress signaling pathways, including the p53 and cFos/Jun signaling. Innate immune signaling is also observed.
Heterozygosity for p53 rescues the HSPC defects and reduces cell stress signaling but leaves innate immune activation in place. Combined Ddx41/p53 heterozygosity results in a highly penetrant, often fatal hem malignancy, modeling aspects of the patient disease.
Also thanks to my entire team for their contributions and to @dstarczynowski for his support and mentorship on the project.
We show that heterozygous loss of DDX41, which models patients with germline predisposition to MDS/AML, causes hematopoietic stem and progenitor cell defects under conditions of stress. The erythroid lineage is particularly affected, resulting in mild anemia.
I am proud to be back in the city where I grew up for a work meeting. The EvansMDS meeting unites many brilliant scientists and clinicians that study MDS to present their work and generate new ideas and collaborations. It’s great to have the meeting come to Louisville
Tim Chlon retweeted
DDX41 mutations ⬇️⬇️
🔹Germline pathogenic variants = relatively common (1/429)
🔹 Increased risk of MDS/AML
🔹Progression more common in somatic DDX41 variants
🔸Responsive to #venetoclax as previously published
#leusm #leukemia #OncoAlert @BloodJournal
doi.org/10.1182/blood.202302… – at Houston, TX
Had a great ride in @RideCincinnati to support the UC Cancer Center with @dstarczynowski and @emmauible . Thanks to all who supported my ride!
The first Chlon Lab Summer BBQ was a fantastic success. I am so honored that this amazing group of people has chosen to work with me, and it was a true joy to host them and their families. I hope this is the first of many to come!
Proud to work at the #1 children’s hospital in the nation! The impact this place has had on me, my family, my city, and my world is immeasurable.
We’re honored to be named the #1 children’s hospital in the nation according to @usnews! This is another amazing first for Cincinnati Children’s and our region and we couldn’t have gotten here without you. #WeAreCincyKids
Tim Chlon retweeted
Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neop… pubmed.ncbi.nlm.nih.gov/3719… @TalhaBadarMD @DrAlexFerrer @tchlon #DDX41 #MDS @MayoCancerCare @MayoCancerCare – at Minnesota, USA
Honored to speak in this amazing lineup!
Exciting Day 2 of our Workshop! We have an amazing line-up of speakers today: @NeugebauerKarla, @tvbowman22, @tchlon, @Doulatov_lab, @andrei_thomas_t, @Halene_lab, @FdAdF66, @hanzhi_luo, @AbdelWahablab, @bradleybio, @nsalomonis, @TothovaLab, @AnnaMarneth & @TannishthaReya 🌟
