Laryngeal carcinosarcoma (sarcomatoid SCC). Sometimes you have to look v hard to find any evidence of epithelial differentiation. This was the only 1mm focus +ve for p40 and cytokeratins. Don’t believe it’s a sarcoma until you’ve done levels and every CK in your armoury #ENTPath

Microscopic colitis with giant cells. Female with autoimmune history and watery diarrhoea, negative micro and endoscopy normal. Unlike CD which has deep granulomas the giant cells in MCwGC are superficial and dispersed. Like CC and LC responds to budesonide. @drkeithsiau #GIPath

Ischaemic small bowel with an unexpected finding! #PathTwitter #GIPath

1/3. Multiple smooth polyps on the lower lip with a clinically benign appearence. Looks benign at low power, agreed? #PathTwitter #ENTpath

Perhaps I’ve had too much coffee but the forceps artefact in this skin biopsy shared with me by @ssaunders279 reminded me of the clashing tusks of a pair of rutting narwhals #pathart #dermpath @ACP_Pathologist

Clear cell metaplasia in a sigmoid polyp from my colleague @edinpath. Resembles secretory endometrium and perhaps Sertoli cells! No clinical importance but pretty! Nice review by Dabir, van der Post & Nagtegaal. Histopathology, 2021. 78: 348-357 #GIpath #Pathologists @pathkids – at Porthtowan, England

Sometimes IHC is not needed but you do it anyway because pictures speak louder than words. Oesophageal biopsy from an elderly man. Right panel is HSV-IHC.