Senior Research Associate in the Cardiovascular Epidemiology Unit, University of Cambridge, UK.
Joined April 2010
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Dr. Scott C. Ritchie retweeted
Check out the latest developments of all things @PGSCatalog, out now in @NatureGenet (🔗: rdcu.be/dVakA )!
In this paper we describe big increases in the data content (and diversity) and our tool for PGS calculation (github.com/PGScatalog/pgsc_c…).
Excited to share our new preprint describing updates to the @PGSCatalog (PGSCatalog.org ) and the PGS Catalog Calulator (pgsc_calc), a new tool for reproducible PGS calculation in the context of genetic ancestry (github.com/PGScatalog/pgsc_c…). Just in time for #ESHG24!
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Dr. Scott C. Ritchie retweeted
New manuscript "Addressing the credibility crisis in Mendelian randomization" is out at @BMCMedicine: bmcmedicine.biomedcentral.co…. We discuss the explosion in MR studies, and what can be done by authors and editors/reviewers to improve the quality of published MR research. Thread:
Dr. Scott C. Ritchie retweeted
I genuinely think RAP is not a bad idea for lots of analyses but 1) this explicitly kills off lots of integrative work where you want to join your data with UKBB but can’t upload it to a cloud 2) immediate rule change with no grace period is baffling community.ukbiobank.ac.uk/hc…
Dr. Scott C. Ritchie retweeted
New preprint: We introduce MrDAG the first causal graphical model for Mendelian randomization (MR) to detect dependency relations within multiple exposures and within multiple outcomes to pinpoint which exposures cause disease
biorxiv.org/content/10.1101/…
Follow 🧵 for more.
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Dr. Scott C. Ritchie retweeted
Congrats @ceclindgren! How lucky our field is to have you! 🌟#eshg2024
Dr. Scott C. Ritchie retweeted
The Polygenic Score Catalog: new functionality and tools to enable FAIR research medrxiv.org/content/10.1101/… PGS calculator nextflow pipeline for polygenic score calculation github.com/PGScatalog/pgsc_c…
Dr. Scott C. Ritchie retweeted
.@konradjk #eshg2024: Biobanks allow us to do "all by all" analyses, where you test the millions of genetic variants against thousands of phenotypes.
Points to work with UK Biobank, specifically Pan-UKB (pan.ukbb.broadinstitute.org/) and Genebass (app.genebass.org/).
Dr. Scott C. Ritchie retweeted
Exciting plans for the next gnomAD (v5) release, including integration of >400K diverse genomes from the All Of Us program, plus federated model to integrate data from national projects around the world (including Australia!). #eshg2024
Dr. Scott C. Ritchie retweeted
How well do EHR-based scores predict disease onset compared to PGS? Can we predict disease onset in Finland using EHR-scores trained in the UK or Estonia? To find out what our @intervene_eu study discovered, come see our poster at #ESHG2024 on 3.6. at 15:45
Dr. Scott C. Ritchie retweeted
Delighted to be in Berlin for #eshg2024! My team at the Centre for Population Genomics in Australia is looking for a senior computational biologist - if this is you, and you’re interested in relocating to Sydney, Melbourne, or NZ, I’d be happy to chat! populationgenomics.org.au/ca…
Dr. Scott C. Ritchie retweeted
If you’re at #ESHG24 and interested in all things @PGSCatalog & calculator (pgsc_calc) we’ll be giving a workshop on Monday (2 PM, shorturl.at/zYurA) with our @GWASCatalog colleagues. But do DM if you want to chat or meetup at the conference!
xitter.cf/GWASCatalog/status/179…
Are you going to #eshg? Join our workshop
shorturl.at/zYurA and learn how to:
📰Prepare your data for submission to the @gwasCatalog and @PGSCatalog
✅Access harmonised #gwas #SumStats and scores
🧮Calculate scores from existing PGS in new samples using PGSC_calc?
Dr. Scott C. Ritchie retweeted
We also describe the PGS Catalog Calculator (pgsc_calc; github.com/PGScatalog/pgsc_c…), an open-source, scalable and portable pipeline to reproducibly calculate PGS in the context of genetic ancestry using reference data panel data from HGDP+1kGP. Prior 🧵: xitter.cf/PGSCatalog/status/1688…
📢MAJOR UPDATE! Genetic ancestry differences are a big challenge for polygenic scores. We @PGSCatalog have updated our calculator with multiple methods to normalise for ancestry.
Check it out: pgsc_calc v2: github.com/PGScatalog/pgsc_c…
ALT Distributions of PGS in different genetic ancestry groups
ALT Subway map describing v2 of the pgsc_calc nextflow pipeline
Dr. Scott C. Ritchie retweeted
Excited to share our new preprint describing updates to the @PGSCatalog (PGSCatalog.org ) and the PGS Catalog Calulator (pgsc_calc), a new tool for reproducible PGS calculation in the context of genetic ancestry (github.com/PGScatalog/pgsc_c…). Just in time for #ESHG24!
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The Polygenic Score Catalog: new functionality and tools to enable FAIR research medrxiv.org/cgi/content/shor… #medRxiv
Dr. Scott C. Ritchie retweeted
Heading to #eshg2024 shortly - we have four post doctoral positions in computational genomics, graph genomes, blood single cell genomics, and statistics coming online soon - get in touch if you are interested in meeting up and discussing any of these
Dr. Scott C. Ritchie retweeted
Thanks for the support, @CAMBRIDGE_CEU! I'm excited to continue working with the CEU and to get to know the @Royalcom1851 community.
Congratulations to @elise_needham who was been awarded a Fellowship from the Royal Commission for the Exhibition of 1851! 🎉
She aims to determine genetic influences on cellular signalling by performing genome-wide association studies on protein post-translational modifications.
Dr. Scott C. Ritchie retweeted
The first paper from the Phipson lab has been published today in Genome Biology! Very proud to share this work, led by the talented @givanna90. SuperCellCyto: efficient analysis of cytometry data. A quick summary follows.
genomebiology.biomedcentral.…
Dr. Scott C. Ritchie retweeted
1/ We are excited to share our preprint on how insulin resistance reshapes human skeletal muscle signalling, and how exercise partially counteracts these effects 🏃 medrxiv.org/content/10.1101/…
🧵A thread: