@simcastle

Biodesigner.

 Bristol
instagram.com/simcastle/
Joined June 2009
  • Tweets592
  • Following114
  • Followers183
16Media
#Engineering is #evolution 🧐 ...perhaps? In the latest from the lab @NatureComms we explore what "#design" might mean when engineering biology and the unifying role of evolution. Work led by the brilliant @simcastle with @Michielstock #synbio doi.org/10.1038/s41467-024-4…
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🚨In new work led by @simcastle, we consider what it means to engineer something and what exactly the design process is. By linking to key engineering literature that has been overlooked by much of #synbio to date, we find evolution is a unifying concept. osf.io/urq9w/
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📢Latest paper out @NatComms "Massively parallel characterisation of engineered transcript isoforms using direct RNA sequencing" We learn to control flows along DNA by repurposing terminators as transcriptional valves! @co_evolver @BrisBioDesign @synbioCDT nature.com/articles/s41467-0…
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"It took years — eight years and counting in exile — for me to realize that I was missing the point: we talk about conspiracy theories in order to avoid talking about conspiracy practices, which are often too daunting, too threatening, too total." edwardsnowden.substack.com/p…
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As always #IWBDA2021 was great! If you'd like to see what my lab is up to, my keynote is now available to watch online. I hope it sparks interest in some of you to go #beyondGFP and #engineerevolution! 🦠💻🛠️🦀 #synbio #biodesign #biocomputation youtube.com/watch?v=gyOI7FmX…

Programming biology – controlling the flow of molecular machines empowering life (IWBDA 2021)

Keynote talk given at the 13th International Workshop on Bio-Design...

youtube.com
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New paper out in @NAR_Open on efficient use of dCas12a for multiplexed gene regulation in yeast 🥳 Epic effort lead by @KlaudiaCiurkot at @DSM as part of the EU SynCrop ETN. Great foundation for future genetic circuit design! #synbio #crispr @BrisBioDesign doi.org/10.1093/nar/gkab529

Efficient multiplexed gene regulation in Saccharomyces cerevisiae using dCas12a

Abstract. CRISPR Cas12a is an RNA-programmable endonuclease particularly suitable for gene regulation. This is due to its preference for T-rich PAMs that a

academic.oup.com
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Sim Castle retweeted
Claire G@PR0FG11 Jun 2021
Great work, Joshua. Extra thanks for all the work you did on revisions for this during your EPSRC fellowship!
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LSB scientists develop the ‘evotype’ to help unlock the power of evolution for better engineering biology. Incredible work from @simcastle, @PR0FG, and @chofski! Find out more at the link below: bristol.ac.uk/news/2021/june…
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🥳 Refined and expanded... our updated “Engineering Theory of Evolution” This underpins a number of tough experimental projects in the lab as we explore how evolution can become become integrated into large-scale biosystem design! @simcastle @PR0FG #synbio preprints.org/manuscript/202…
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I'm sorry but this year it should be called "Lobby Universities, Funders and Governments To Actually Give a Damn About Postdocs Week" here's why... ⬇️
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📢An engineering theory of evolution! First preprint out from @simcastle introducing the concept of 'evotype' to enable us to reason about & design the evolutionary potential of engineered biological systems. @PR0FG @BrisBioDesign #synbio #evolution preprints.org/manuscript/202…
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The Zoetic Society @RCA artist's laboratory debate @imperialcollege @LondonBioHack many thanks to our great panel!
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Zoetic Society #1 last night with hosts @simcastle #tonycho and incredible panel @PaulFreemont @OronCatts @MouldGod
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DIY #microfluidics workshop in London Dec 9 with @simcastle xitter.cf/BioFuturesLab/status/6… – at London, England
BioFutures Lab@BioFuturesLab26 Nov 2015
Microfluidics Design Workshop by @simcastle, Dec 9th @ Somerset House eventbrite.co.uk/e/microflui… - Design, 3D print and test your own device
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Sim Castle retweeted
@pcronald@pcronald6 Nov 2015
#GMO activist promoting conspiracy theories to discredit scientist is funded by #organic group examiner.com/article/relentl… #Climategate #biogate
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When might we realize $1k synthetic genomes? What $/bp required? Made rough projections @rob_carlson @eric_lander
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Sim Castle retweeted
Ecovative@ecovative27 Apr 2015
Grow It Yourself Mushroom Material is now available at shop.ecovativedesign.com. Bring your sustainable ideas and products to life! #ecogiy
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My new podcast episode for @TransistorShow is out! All about skin & bacteria, featuring @aobiome @Biocouture and more transistor.prx.org/2015/04/t…
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Ah yes. April fools day... The only day of the year newspapers knowingly publish bullshit...
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What if instead of trying to create new antibiotics, we removed the antibiotic-resistant genes? medium.com/the-os-fund/a-new… @SynBioBeta
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