Biodesigner.
Bristol
Joined June 2009
- Tweets592
- Following114
- Followers183
- Likes224
Latest paper, Engineering is Evolution, is now out in @NatureComms! It was great fun working on this one with @chofski and @Michielstock doi.org/10.1038/s41467-024-4…
Sim Castle retweeted
#Engineering is #evolution 🧐 ...perhaps? In the latest from the lab @NatureComms we explore what "#design" might mean when engineering biology and the unifying role of evolution. Work led by the brilliant @simcastle with @Michielstock #synbio doi.org/10.1038/s41467-024-4…
Rhythmic Attractor, an album of biodelic music, is now on SoundCloud
on.soundcloud.com/rwJQs
Sim Castle retweeted
🚨In new work led by @simcastle, we consider what it means to engineer something and what exactly the design process is. By linking to key engineering literature that has been overlooked by much of #synbio to date, we find evolution is a unifying concept. osf.io/urq9w/
Sim Castle retweeted
📢Latest paper out @NatComms "Massively parallel characterisation of engineered transcript isoforms using direct RNA sequencing" We learn to control flows along DNA by repurposing terminators as transcriptional valves! @co_evolver @BrisBioDesign @synbioCDT nature.com/articles/s41467-0…
Sim Castle retweeted
"It took years — eight years and counting in exile — for me to realize that I was missing the point: we talk about conspiracy theories in order to avoid talking about conspiracy practices, which are often too daunting, too threatening, too total." edwardsnowden.substack.com/p…
Sim Castle retweeted
As always #IWBDA2021 was great! If you'd like to see what my lab is up to, my keynote is now available to watch online. I hope it sparks interest in some of you to go #beyondGFP and #engineerevolution! 🦠💻🛠️🦀 #synbio #biodesign #biocomputation youtube.com/watch?v=gyOI7FmX…
"carbon footprint" is a concept invented by BP to shift responsibility away from oil companies and onto individuals mashable.com/feature/carbon-…
Sim Castle retweeted
New paper out in @NAR_Open on efficient use of dCas12a for multiplexed gene regulation in yeast 🥳 Epic effort lead by @KlaudiaCiurkot at @DSM as part of the EU SynCrop ETN. Great foundation for future genetic circuit design! #synbio #crispr @BrisBioDesign doi.org/10.1093/nar/gkab529
Turns out several creationist blogs have (wilfully?) misunderstood our paper. For the record: the thesis is that engineers can design *with* evolution, NOT that evolution came about through engineering. nature.com/articles/s41467-0…
I wrote a blog post about the paper I wrote with @chofski and @PR0FG #evotype #evolutionaryengineering
bioengineeringcommunity.natu…
Sim Castle retweeted
LSB scientists develop the ‘evotype’ to help unlock the power of evolution for better engineering biology.
Incredible work from @simcastle, @PR0FG, and @chofski!
Find out more at the link below:
bristol.ac.uk/news/2021/june…
One of the biggest inspirations for my art, music, and science is the beauty that exists between order and chaos. This is the region where life can evolve, where meaning emerges from information, and where consciousness is possible.
instagram.com/p/CP2cHi8pueR/…
My first paper is out today in Nature Comms "Towards an engineering theory of evolution"
📢Our latest paper "Towards an engineering theory of evolution" where we consider the interwoven nature of #evolution & #synbio is out now in @NatureComms! 🎉 Lots to think about in this one. 🧐@simcastle @PR0FG @BrisBioDesign @BristolBioSci doi.org/10.1038/s41467-021-2…
Sim Castle retweeted
🥳 Refined and expanded... our updated “Engineering Theory of Evolution” This underpins a number of tough experimental projects in the lab as we explore how evolution can become become integrated into large-scale biosystem design! @simcastle @PR0FG #synbio preprints.org/manuscript/202…
Sim Castle retweeted
📢An engineering theory of evolution! First preprint out from @simcastle introducing the concept of 'evotype' to enable us to reason about & design the evolutionary potential of engineered biological systems. @PR0FG @BrisBioDesign #synbio #evolution preprints.org/manuscript/202…
