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The secret life of LIRs: Binding to Atg8-family proteins is just a fraction of what LIRs can do....
New Perspective: Brian North, Christopher Shoemaker @shoemaker_lab et al. @GeiselMed highlight emerging evidence that LIRs act as protein interaction hotspots, coordinating diverse protein–protein interactions across the #autophagy pathway. hubs.la/Q03yMFKv0
Hello??? Is this thing on???
In case it is, we're excited to share Brian's recent work on the expanded role of LIRs in autophagy (spoiler alert: they do much more than bind LC3). Huge thanks to all who were involved in this study!
North, Shoemaker et al. @GeiselMed define the LC3-interacting region (LIR) of NBR1 as a multifunctional binding site that recruits ATG8 proteins, FIP200, and TAX1BP1 to drive autophagic flux. hubs.la/Q035-K7N0
#Biochemistry #autophagy
Congrats to Sarah Lamson for successfully defending her undergraduate honors thesis! We will greatly miss her presence around lab.
Best wishes on the next step of your scientific journey!
Very excited to welcome our newest grad student, @AdwaitaBose, to the lab!! Looking forward to all that she brings to our team!
🎉Congrats Dr. Delgado! @jmdelgado_ 🎉 A fantastic thesis defense from an inaugural member of @shoemaker_lab. We couldn't be more proud!
Congrats José! A great talk at Keystone and an even greater contribution to science in your thesis work!
Last week I had the opportunity to present my main thesis work at #KSautophagy24 in Keystone, CO.
Today, that work is finally published online @embojournal! embopress.org/doi/full/10.10…
Shoemaker Lab retweeted
Still doing some grad school shopping? 🛍️ This is the last week to apply to MCB - applications are due Friday, Dec. 1! Learn more and apply here ✍️
graduate.dartmouth.edu/mcb/a…
P.S. It doesn't need to be Cyber Monday... we have no application fee any time 💸
Shoemaker Lab retweeted
The @LaughneyLab and @WeillCornell is recruiting innovative postdocs with expertise in variational inference, dynamical systems, and/or computational systems biology to study inter-cellular communication in the tumor microenvironment! Pls RT, job posting: laughneylab.com/join-the-tea…
Welcome to the new MCB first-year cohort 🎉
The Shoemaker Lab had a blast talking to you all during this year's MCB retreat!
Another BIG moment for the Shoemaker Lab: Congratulations to Sam for passing her qualifying exam!! Next stop, doctorate! 🎉
Welcome to our newest lab member, Carter! Can't wait to see all the cool things you do during your PhD journey. 🎉🥶
Congratulations for our extraordinary lab member Logan Wallace for accepting her offer to @HopkinsCMDB for her PhD!!! We are sad to see her leave and move on to do great things.
We're privileged to get to work with such incredibly talented and dedicated students. @Muhamma13627355 @Sci_Bea @jmdelgado_ Congrats to all nominees whose work is making a huge difference at Dartmouth and beyond!
Replying to @MCBDartmouth
Honorable Mention for the Diversity Award was shared by @Sci_Bea (@DionnaKasper Lab) and @jmdelgado_ (@shoemaker_lab)! Beatriz and Jose are integral to the launch and success of @sacnasdartmouth, fostering an inclusive and supportive STEM community @MsbDartmouth @DartmouthBCB
Huge shout out to @jmdelgado_ and the whole lab for a job well done!!!
José prevailed in an epic showdown against both #mitophagy AND tail-anchored proteins! See his thread for a full accounting.
I am so excited to present my first publication of thesis work! 🙌🏽 Would not have been possible without Chris @shoemaker_lab and my fellow lab mates.
Our story brings together #mitophagy, tail-anchored proteins, and quality control.
A 🧵;
biorxiv.org/content/10.1101/…
Shoemaker Lab retweeted
Join us for our monthly meeting on February 8th at 12 pm in Haldeman center 041! Pizza and refreshment will be served 🍕
Shoemaker Lab retweeted
I'm excited to share that the Landino Lab will officially open this summer at at Dartmouth Geisel School of Medicine in @DartmouthBCB We will investigate cytoskeletal dynamics and cell division using Xenopus 🐸 We're recruiting at all levels - please share!























