@LaughneyLab
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Associate Professor @weillcornell @wcm_MeyerCancer Systems Biology of Metastasis
New York, NY
Joined February 2018
- Tweets508
- Following936
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!! Recruiting postdocs in deep learning and graphs, dynamical systems, & computational biology to map the context-dependent effects of multicellular programs and pleiotropic proteins in cancer progression. We can provide exciting, first-in-class data! laughneylab.com/join-the-tea…
Ashley Laughney retweeted
Early findings from a first-in-human trial of VLS-1488, an oral KIF18A inhibitor, show promising anti-tumor activity in heavily treated ovarian cancer. No dose-limiting toxicities were observed. Presented by Dr. Ecaterina Dumbrava at #ASCO25. #EndCancer
Ashley Laughney retweeted
(1/2) A very exciting milestone for @VolastraTx and the field of #Chromosomal_Instability. Early escalation data for our KIF18A inhibitor, VLS-1488, show excellent safety and promising efficacy in heavily pre-treated ovarian cancer patients. businesswire.com/news/home/2…
Ashley Laughney retweeted
Join us for the next @WCMEnglanderIPM #PrecisionMedicine Journal Club where Tri-I Computational Biology and Medicine (@cbm_student) graduate student Austin A. Varela (@AustinAVarela) will present a @Nature paper from Sept. 2024!
Ashley Laughney retweeted
Another elegant study by @eileen_parkes group showing how chronic #cGAS #STING activation from #Chromosomal_instability shapes the tumor microenvironment of esophageal #cancer biorxiv.org/content/10.1101/…
Ashley Laughney retweeted
We hope to see you Thursday for the next @WCMEnglanderIPM #PrecisionMedicine Journal Club presented by @cbm_student @EthanEarlie on Thursday, April 24th from 3-4 pm in Belfer #1401 and via Zoom (DM for details)!
The next @WCMEnglanderIPM #PrecisionMedicine Journal Club will review the @Nature article "MHC Hammer Reveals Genetic and Non-genetic HLA Disruption in Cancer Evolution," presented by @cbm_student @EthanEarlie April 24th from 3-4 pm in Belfer #1401 and via Zoom (DM for details)!
Ashley Laughney retweeted
Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇nature.com/articles/s41586-0…
Ashley Laughney retweeted
Congratulations to Dr. Victor R. Ambros, former member of the @dartmouth Dept. of Biological Sciences and Geisel Dept. of Genetics, for being awarded the 2024 #NobelPrize in Physiology or Medicine, for the discovery of microRNA. home.dartmouth.edu/news/2024…
Ashley Laughney retweeted
Tumor Heterogeneity and Evolution:
Nicholas Navin, Christina Curtis, and Ashley Laughney will address this topic in an educational session at #SABCS24 (December 10-13). Learn more:
bit.ly/4eNLvcq
@nicholas_navin @cncurtis @LaughneyLab
Ashley Laughney retweeted
Together with @CharlesSwanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…nature.com/articles/s41588-0…...
🧵below
Ashley Laughney retweeted
1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer #micronuclei is out in @ScienceMagazine today. A story led by the brilliant @melodyDiBona it started with a simple question: why do micronuclei rupture?
science.org/doi/10.1126/scie…
Micronuclear collapse triggers chronic STING signaling that drives metastasis. But how do they rupture?? Beautiful work from the @Samuel_Bakhoum lab, led by brilliant physicist turned hard core cell biologist @melodyDiBona, explains how..
Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse.
Learn more in this week's issue: scim.ag/8bF
See also the amazing companion paper by the @SteSantaguida lab! Both shed important new light on this phenomenon. What a day for the field of #chromosomal #instability #CIN
Ashley Laughney retweeted
Very happy to have DNA O-MAP out!
The DNA version of this work, started from a simple premise: how can we measure the proteome at any genomic loci in (nearly) any cell?
This was a great collaboration with @oligopain, and led by Yuzhen Liu and @CD_McGann.
1/8🧵
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Ashley Laughney retweeted
Our new study, published today @CD_AACR, reveals that iron chelation therapy unleashes innate immune responses that control #OvarianCancer. Congrats to first author @titosandoval84 and the whole team. #Immunotherapy @WeillCornell @WCM_OBGYN 👇doi.org/10.1158/2159-8290.CD…
ALT https://doi.org/10.1158/2159-8290.CD-23-1451
Ashley Laughney retweeted
Our second of a pair of reviews on how
#Chromosomal_instability #CIN drives #cancer progression is out in @NatureRevGenet Reviews led by the talented @chenxuelan621 @itsalyourpal @JunLi_916 @melodyDiBona nature.com/articles/s41576-0…
Ashley Laughney retweeted
Our first of a pair of reviews on #Chromosomal_Instability is out in @NatRevClinOncol on targeting CIN in patients with #cancer written with the amazing @RawiDuaa @EmanueleLettera @JunLi_916 @melodyDiBona nature.com/articles/s41571-0…
Sincerest of thanks to the @psscra for supporting scientists, taking risks on new ideas, and to the amazing teams working to realize them! Congrats to all awardees.
We are so excited to announce our five winners of the 2024 Pershing Square Sohn Prize. These five brilliant scientists are:
1. Santosha Vardhana, MD, PhD
2. Juan Pablo Maianti, PhD
3. Ashley Laughney, PhD
4. Teresa Davoli, PhD,
5. Samuel Bakhoum, MD, PhD
psscra.org/2024/06/04/press-…
Proud PI :) Congrats @EthanEarlie on passing your @cbm_student qual!!
