Researcher in vaccine immunology, avid cyclist, and world traveller. Postdoc in the King lab @UWproteindesign. he/him
Seattle, WA
Joined June 2011
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Sebastian Ols retweeted
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Crossover episode! We introduce RFD4-Proteina, our latest design model - and the result of a year-long collaboration between the Baker Lab and NVIDIA GenAIR (the name says it all…). I hope you’ll agree - the results are astonishing. 🌐 Website: rfd4-proteina.org/
Sebastian Ols retweeted
Avengers assemble: 1 year BakerLab + NVIDIA GenAIR = 🔥 rfd4-proteina.org
Presenting RFD4-Proteina, our latest protein design model, significantly better and faster than everything we compared against, both in silico and in the lab! 1/30
Sebastian Ols retweeted
It's finally out as a paper :D
🧵1/ Introducing scifer, our R/Bioconductor package developed with B cell receptor (BCR) sequences in mind, but adaptable to other sequence types. Pre-trained on real datasets, scifer is designed to streamline index cell sorting sequencing workflow
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Sebastian Ols retweeted
This year’s #NobelPrize laureates in chemistry have revealed proteins’ secrets through computing and artificial intelligence.
Chemists have long dreamed of fully understanding and mastering the chemical tools of life – proteins. This dream is now within reach. 2024 chemistry laureates Demis Hassabis and John M. Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. This year’s chemistry laureate David Baker has learned how to master life’s building blocks and create entirely new proteins. The potential of their discoveries is enormous.
The ability to create proteins that are loaded with new functions is just as astounding. This can lead to new nanomaterials, targeted pharmaceuticals, more rapid development of vaccines, minimal sensors and a greener chemical industry – to name just a few applications that are for the greatest benefit of humankind.
Sebastian Ols retweeted
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Sebastian Ols retweeted
We want to extend our warm congratulations to 2023 @NobelPrize Laureates Katalin Karikó and Drew Weissman! It was an honor to publish their key findings for the Physiology or Medicine prize: cell.com/immunity/fulltext/S… @kkariko @WeissmanLab @pennmedicine #NobelPrize
Sebastian Ols retweeted
Congratulations @sebbeols @KingLabIPD and not on x Karin Loré and colleagues! Great work! 🎉💪
Online now: Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses dlvr.it/SvqB4G
Sebastian Ols retweeted
Online now: Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses dlvr.it/SvqB4G
Happy to share our latest publication @ImmunityCP: Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses
cell.com/immunity/fulltext/S…
All in all, a fantastic collaboration with multiple researchers @karolinskainst @KingLabIPD @UWproteindesign @NIH @unil @BellinzonaIrb
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Sebastian Ols retweeted
It's an incredible day for structure-based vaccine design, and I'm thrilled to see our prefusion RSV F antigen get approved as the first RSV vaccine. Still more work to do to reduce the RSV disease burden, but this will help! Congrats @BarneyGrahamMD! cnn.com/2023/05/03/health/fi…
Super happy and proud to share that I am one of the recipients of the KI Sven Gard Prize for the best virology doctoral thesis during 2022.
news.ki.se/katie-healy-and-s…
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Sebastian Ols retweeted
Recently @Migrationsverk Swedish Migration Agency announced new residence permit rules for doctoral students. A step in right direction but we still have a way to go. This Sunday the PhD students of @karolinskainst and @KTHuniversity hosts a manifestation against the Aliens Act
Great opportunity in an exciting and forward-thinking lab.
We are looking for a postdoc to join an extremely exciting project! Do you want to know what #gdTcells recognize? To investigate function of a novel gdTCR ligand candidate? To understand what gdT-TILs recognize in tumors? Join us @karolinskainst! Pls RT.
ki.varbi.com/what:job/jobID:…
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Very cool study from colleagues @karolinskainst! A public antibody lineage can evolve to acquire potent cross-neutralization.
We recently discovered that a “public” class of antibodies (one that most people should be able to make) can mature to cross-neutralize Omicron, and all other SARS-CoV-2 variants we tested: biorxiv.org/content/10.1101/…
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Sebastian Ols retweeted
Evolution 101. 🧵
Mutations occur as chance errors in replication. They're just mistakes in copying. Most have no effect. Some are detrimental to the organism (or virus), a few may happen to be beneficial -- this depends on the environment.
Sebastian Ols retweeted
Great piece on RSV vaccine and antibody development. We should soon have more interventions available to fight this virus!
RSV vaccines are closer!- an interview in @JAMA with @McLellan_Lab @RSVnews @ReSViNET jamanetwork.com/journals/jam…