SchwartzLabMIT (@schwartzlabmit) profile picture

SchwartzLabMIT

@schwartzlabmit

Nucleo-cytoplasmic communication. MIT, Department of Biology @MITBiology #structuralbiology #cellbiology #cryoEM #Xrays

 Cambridge, MA
Joined October 2018
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New paper from the lab out today on how the assembled HIV-1 capsid mimics nuclear transport receptors to pass the nuclear pore complex. Fantastic collaboration with Dirk Görlich @mpi_nat ! rdcu.be/dwPq5
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Congratulations to all the labs that have contributed to this extraordinary feat @hoelza @Beck_Laboratory @jankosinski @WuLabHarvard and others. Looking forward to seeing the structural knowledge being used for detailed functional analyses in the future.
Science Magazine (@ScienceMagazine) profile pictureScience Magazine
@ScienceMagazine9 Jun 2022
A new special issue of Science reveals a near-atomic picture of the human #NuclearPoreComplex—an elaborate structure composed of hundreds of proteins that mediates the exchange of material between a cell’s nucleus and the surrounding cytoplasm. Read more: fcld.ly/ge0hm77
Image from Science Magazine (@ScienceMagazine)
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Very sad to see Ned Seeman pass away. One of my favorite papers from grad school, back then in the pre-PDF era proudly photocopied in the cavernous MIT library. One of the great Rich lab alumni. What an inspiration he was.
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MIT Biology (@MITBiology) profile picture
MIT Biology@MITBiology14 Oct 2021
A team led by @aschuller17 & @schwartzlabmit found a way to analyze the nuclear pore complex directly inside cells. The pore has larger dimensions than previously thought—showing just how vital it is to study complex molecules in their native environments: bit.ly/3lGpNyl
A model of the human nuclear pore complex depicts the major proteins that make up the pore’s three rings. Top to bottom: The Cytoplasmic Ring is blue and yellow; the Inner Ring is orange and pink; and the Nucleoplasmic Ring is light blue and gold.

ALT A model of the human nuclear pore complex depicts the major proteins that make up the pore’s three rings. Top to bottom: The Cytoplasmic Ring is blue and yellow; the Inner Ring is orange and pink; and the Nucleoplasmic Ring is light blue and gold.

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Excited to share my work from @SchwartzLabMIT in @MITBiology titled “The cellular environment shapes the nuclear pore complex architecture” online today in @Nature! nature.com/articles/s41586-0… #cryo-EM #cryo-ET #TeamTomo #NPC 1/n
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Out today: nature.com/articles/s41586-0… Native environment significantly influences shape of the NPC. First venture into cryo-ET. Great work by the infatigable @aschuller17 and wonderful collaborators: Medalia lab @UZH_ch @KarstenWeisLab @MDassolab @mit_nano @kochinstitute
The cellular environment shapes the nuclear pore complex architecture

The cellular environment shapes the nuclear pore complex architecture

Nature - Structure of human nuclear pore complex in its cellular environment reveals a substantially dilated central channel and shows that its nucleoplasmic and cytoplasmic rings restrict channel...

nature.com
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BIG Congratulations to Elizabeth @TheVillaLab for becoming a new HHMI investigator! Great to see.
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