Updates from the Roybal Lab at UCSF. We are focused on engineering the next generation of immune cell therapeutics.
San Francisco
Joined March 2021
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Roybal Lab retweeted
Presenting a new “CAR Pooling” technique, @dbgoodman, @KoleRoybal, and co. comb through domains from various immune lineages to build new #CARTCell designs and identify several that boost anticancer efficacy against #MultipleMyeloma in mice. @parkerici scim.ag/uM
Roybal Lab retweeted
Why test #celltherapies one-by-one when you can use #SynBio to design, learn, and iterate on thousands in parallel? Our team @UCSF @MarsonLab @roybal_lab is #hiring a wetlab technician to help build the next revolution in genetically engineered medicine! DM for info & please RT!
Roybal Lab retweeted
Excited to share our paper @CellCellPress tinyurl.com/22s9pztn. Ray Liu and Iowis Zhu led the development of clinically optimized and tunable nextgen synNotch receptors dubbed SNIPRs for cell therapies. Thank you @UCSF @GladstoneInst @parkerici press: tinyurl.com/2p8usz7z
Congratulations to @CamilliaAzimi for her Graduate Women in Science Fellowship @GWISci awarded to just seven outstanding women scientists during the 2020-2021 funding cycle. Exceptional work Camillia, you continue to impress!
#womeninSTEM
#womeninscience
Roybal Lab retweeted
Excited to share new work w/ co-lead @CamilliaAzimi, @MarsonLab @kickassscience1 @roybal_lab: using a method we call 'CAR Pooling', we tested many CARs in multiplex & found new non-T cell signaling domains which improve CAR-T efficacy. biorxiv.org/cgi/content/shor… 👇🧵 1/10
Congratulations to Roybal lab Post Doc Ray Liu and MD/PhD student Iowis Zhu for their engineering of SyNthetic Intramembrane Proteolysis Receptors (SNIPRs). Preprint is up now!
1/4 Excited to share our new preprint from the @roybal_lab & @MoKhalilLab-Raymond Liu and Iowis Zhu led the development of NextGen synNotch receptors. SynNotch is one ‘species’ in a larger ‘genus’ of SyNthetic Intramembrane Proteolysis Receptors (SNIPRs) tinyurl.com/7kf6bdyr
Roybal Lab retweeted
Two teams have created a new generation of highly specific CAR T cells, which safely cleared solid tumors in mice with mesothelioma, ovarian cancer, and the deadly brain cancer glioblastoma.
Read more in @ScienceTM:
➡ fcld.ly/pf2d4wc
➡ fcld.ly/tb2q2ir
Congratulations to @roybal_lab members Axel and Julie for their publication in Science Translational Medicine! This paper investigates novel synNotch CAR circuits that enhance tumor recognition through combinatorial antigen signatures in mesothelioma and ovarian cancer.
Roybal Lab retweeted
Today #AACR21: @KoleRoybal on-demand session "Towards Engineering of Neoantigen-Specific T-Cell Therapies" followed on 4/13 with panel discussion. @CDI_UCSF @immunox @parkerici | See full list of @UCSF presentations: ow.ly/r78q50Elalq
