Michael Sehorn retweeted
We found that human RAD52 adopts a newly identified open-ring conformation, in addition to the previously known closed-ring, and solved both structures using cryo-electron microscopy (3/8)
Michael Sehorn retweeted
...and used cryo-electron microscopy to solve its structure bound to ssDNA (5/8)
Michael Sehorn retweeted
We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) nature.com/articles/s41586-0…. Thread ⬇️⬇️⬇️ (1/8)
Michael Sehorn retweeted
Dancing DNA polymerases? The essential steps in DSB repair pathway a-EJ/MMEJ/TMEJ are mediated by alternating engagements of Polymerases theta and delta (yes, Pol delta, the same polymerase that does lagging strand synthesis) – read about it in Nature rdcu.be/drbuG
Michael Sehorn retweeted
Excited to share this #preprint on @researchsquare accepted today in Molecular Cancer. EYA4 drives breast cancer progression and metastasis through its novel role in replication stress avoidance. researchsquare.com/article/r… Superb group effort w/ @bdelapenavalos @RTropee @DuijfLab
This is an excellent paper by @copenhaverlab on ubiquitin mediated degradation of atDMC1. nature.com/articles/s41467-0…
Michael Sehorn retweeted
Very happy to share our recent work on single-molecule imaging of 3418 aa-long protein monster known as the BRCA2 tumour suppressor! Great collection with @LukeGreenhough @BoultonLab @SCWestLab
Our latest📰! Out today in @MolecularCell We used single-molecule imaging to directly observe human BRCA2 tumour suppressor in action! Spearheaded by @BelanOndrej & @LukeGreenhough. A thread. (1/10)
sciencedirect.com/science/ar…
Michael Sehorn retweeted
Happy to share our collaborative C-trap @LUMICKS_nl study on the BRCA2 tumour suppressor - nucleating RAD51 on ssDNA and surprisingly sliding on dsDNA! 🧬
Our latest📰! Out today in @MolecularCell We used single-molecule imaging to directly observe human BRCA2 tumour suppressor in action! Spearheaded by @BelanOndrej & @LukeGreenhough. A thread. (1/10)
sciencedirect.com/science/ar…
Michael Sehorn retweeted
Just joined MCB as Senior Editor. Consider submitting your manuscripts. @tandfonline @unisevilla @CSIC
Michael Sehorn retweeted
Looks like Joan is a clue in the WashPo crossword puzzle today! 🤓
washingtonpost.com/crossword…
Michael Sehorn retweeted
One for the single-molecule and nucleic acids crowd.
Sharing a pre-print of a side project I developed when I was in Steve Kowalczykowski’s lab. We developed a method, using RecA protein, to add site-specific anchors to large DNA molecules - while maintaining their topology.
A programmable and site-specific anchoring system for biophysical analysis of DNA:protein interactions on large topologically closed ... biorxiv.org/cgi/content/shor… #biorxiv_biophys
Michael Sehorn retweeted
RPA engages telomeric G-quadruplexes more effectively than CST dlvr.it/Sp2S1k
Michael Sehorn retweeted
Congratulations to a great colleague, friend, and lab neighbor, Marc World @IowaBiochem
Marc was honored as an Impact Scholar in the @IowaMed
Michael Sehorn retweeted
Lesion recognition by XPC, TFIIH and XPA in DNA excision repair nature.com/articles/s41586-0…
Michael Sehorn retweeted
A caring mentor is SO important, but there are lots of other barriers: immigration/ visas, support for parents including new mothers, affordable housing and much more… Mentors also need to advocate for institutional change to support their trainees.
Michael Sehorn retweeted
Only 10 days left to apply for this #postdoc position!! ⬇️⬇️
Don't miss your opportunity!
We are looking for a highly motivated Junior #postdoc!
If you are interested in #telomeres, #cancer and #aging, come join our team
@IMMolecular, in Lisbon!
Apply until April 20th
All the info at euraxess.ec.europa.eu/jobs/8…
RTs are welcomed!
