is this tryptophan cage miniprotein?

Can fluorine chemistry survive the upcoming TFA ban? Our newly published open-access review with @MykhailiukChem in Chemical Science explores what the fluoroorganic toolbox has to offer: doi.org/10.1039/d6sc04959a

Application of phosphonoproline in peptidomimetic design. Mind the chirality of the phosphorus center! doi.org/10.1021/acsmedchemle…

This is a really pretty review on SCF3 chemistry focusing on amino acids and peptides. By Thierry, Greg and the team doi.org/10.1021/acs.joc.6c00…

And then the second one by a mixed group from China, who summarize a large massive of information on proline and its derivatives published between 2020-2025 in the medicinal chemistry context: doi.org/10.1016/j.ejmech.202…

For the record, it is really important to mention two really deep review articles published earlier this year about the application of proline analogues in medicinal chemistry. First one written by the living legends, Hanessian and Meanwell: pubs.acs.org/doi/abs/10.1021…

There is a pretty cool recent publication that introduces bridgehead substituted [2]ladderanes as ortho-aromatic bioisosteres. Practical synthesis, structural analysis, and bioactivity validation. pubs.acs.org/doi/abs/10.1021…

Proline-rich antimicrobial peptides are still out there combating some nasty pathogens: doi.org/10.1021/acsinfecdis.…

Selective targeting of the key enzyme in proline biosynthesis: doi.org/10.1021/acschembio.6…

Well, this is interesting set of data. The effect of azetidine-2-carboxylic acid exposure on neuroblastoma cells. doi.org/10.1016/j.fct.2026.1…

Did you know that in chemistry you can ride bicycles? Very small. Really tiny. Yet, they can take you places you've never thought before. Discover what these bicycles can do to bring us close to novel drugs in our recent review with @MykhailiukChem pubs.acs.org/doi/10.1021/acs…

What a sad message 😟 this used to be such a useful resource. Thank you, molinspiration team!

Production of xenoproteins on a gram scale. The incorporated noncanonicals include fluoroprolines. Looks pretty cool to me! 👍🏾 doi.org/10.1002/cbic.2025006…

sincere congratulations! 🥂

Very much enjoyed reading the newest review from Ned, Hamid and Huy on genetic code engineering. A summary of efforts, pitfalls and challenges. doi.org/10.1002/cctc.2025008…

Really impressive review article on how to improve substance's solubility AND permeability at the same time, the trait combination that the authors called Aufheben. Great summary of strategies and examples from contemporary drug design! Open access doi.org/10.1021/acs.jmedchem…

Just learned that chronic Staph. aureus readjusts its metabolism to feed on proline from collagen deposits. Mindblowing! doi.org/10.1038/s41564-024-0…

A whole panel of 5-spirocyclic proline analogues prepared by colleagues from Enamine doi.org/10.1039/D4OB01669F

Another amazing work from the group of JC Horng, unveiling the effects of cation-pi interactions in the assembly of the collagen triplex doi.org/10.1021/acs.jpcb.4c0…

A fold stabilizing effect of a proline analogue on a 36 residues miniprotein doi.org/10.1038/s42004-025-0…