Can fluorine chemistry survive the upcoming TFA ban? Our newly published open-access review with @MykhailiukChem in Chemical Science explores what the fluoroorganic toolbox has to offer: doi.org/10.1039/d6sc04959a

What a sad message 😟 this used to be such a useful resource. Thank you, molinspiration team!

I got a couple of new postcards from Genova and Berlin. Thank you for the Christmas cheer, Lars! Happy 2025, everyone! I hope for a better year for all of you. Let your efforts pay off this year, my dear friends! 🍾🥂🎄🥳

Really good article published few months ago about the choice of linker for drug macrocyclization. Many clever ideas. doi.org/10.1021/acs.jmedchem…

Here is a nice new article on fluoroproline labelling of huntingtin protein and subsequent 19F NMR: doi.org/10.1002/chem.2024037… As we speculated in our Chem Rev article, this type of labelling could make sense in proline-rich or polyproline domains, which is the case here.

A deep dive into the biochemistry of azetidine-2-carboxylic acid aimed to reveal toxic effects of this noncoded proline analogue on humans and other species. It's a little funny to see how much more intensively this molecule was researched back in the past doi.org/10.1016/j.tox.2024.1…

New spirocyclic proline analogues via a robust synthesis approach. doi.org/10.1021/acs.joc.4c02…

Our dedicated review on the use of proline analogues in drug design focusing on the past 15 years of development, and containing suggestions for the future. With Pavel @MykhailiukChem ASAP article in #JMedChem Check it out, it's really interesting! pubs.acs.org/doi/10.1021/acs…

Thank you @TheRubiniGroup for the cute postcard from Nagoya, Japan! I hope you enjoyed the CPS Meeting you attended and the view of mount Fuji 🗻 I really appreciate it. It almost feels like I can travel again 😁

Amazing recent work on presudoprolines forming polyproline-2 helix by Greg Chaume and the team! Another one polyproline-2 crystal structure to the existing collection. doi.org/10.1039/D4CC02895C