Neuroscience stuff | Postdoc @Stanford_PMHW | https://xitter.cf/t.co/xjh6fV4j58 |
Joined September 2018
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There's so much to be impressed by in this paper, but even more bookmark-worthy if you use ABCD. Painstakingly built foundations on how to deal with interplay between site effects, scanner upgrades, QC ... etc. As typical for Steven and Ted, a ton of well-documented code too
Excited that this paper, "Highly replicable multisite patterns of adolescent white matter maturation", has now been published in Neuron! It may be found at cell.com/neuron/fulltext/S08…. To freely access the paper for the next 50 days, please use this link: authors.elsevier.com/c/1nxdd…
pines retweeted
How does executive function develop during adolescence—and when is it most closely linked to mental health? See our @NatureMentalHealth paper：Developmental Benchmarks of Executive Function Reveal Sensitive Periods for Adolescent Mental Health.
nature.com/articles/s44220-0…
pines retweeted
1/6 🍄 What happens in the brain under psilocybin?
I’m excited to share our new preprint:
“Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics.”
biorxiv.org/content/10.64898…
#Psilocybin #Psychedelics #Neuroscience #OpenScience
New work on the effects of psychedelics on hierarchical cortical propagations out in PNAS! pnas.org/doi/10.1073/pnas.25…
Counter to our expectations, psychedelics attenuated bottom-up propagations into the Default Mode Network across substances and species. Thread below:
That psychedelics reduce bottom-up activity propagations into the DMN directly informs how we may think about their impact on brain function. These results support recent theories highlighting how psychedelics can attenuate bottom-up processing rather than strengthening it.
pines retweeted
PNAS
Traveling-wave transcranial alternating current stimulation (twtACS) causally links neural timing to cognitive function
This study developed a new brain stimulation method called traveling-wave transcranial alternating current stimulation (twtACS). Unlike conventional brain stimulation, twtACS creates electrical waves that move across the brain in a specific direction, similar to natural neural traveling waves.
The researchers showed that these artificial traveling waves could:
Change the timing of neural activity in the brain
Control how signals propagate across brain regions
Improve cognitive performance in humans depending on the direction of the wave
They confirmed these effects using:
Human intracranial recordings
Monkey neural recordings
Human behavioral experiments
The study suggests that traveling waves are not just correlated with cognition but may causally influence cognitive function. This introduces a new way to noninvasively manipulate brain communication and potentially treat neurological disorders.
pnas.org/doi/full/10.1073/pn…
pines retweeted
How does TMS — a treatment for depression — reshape dysfunctional brain circuits?
In our new Cell paper, we identify a cell type-specific prefrontal mechanism linking accelerated iTBS to antidepressant-like behavioral effects and circuit plasticity.
cell.com/cell/fulltext/S0092…
pines retweeted
What are the neural correlates of human behavior?
Much research has approached versions of this question between individuals but not within individuals. Are results from these 2 approaches similar? No!
In over 4000 individuals, the neural correlates of cognitive control diverged between vs. within individuals -- a case of non-ergodicity and Simpson’s paradox.
We think that non-ergodicity may be an important principle in human neuroscience. [1/12]
