Deep tech is a team sport played across continents. I talk to the founders, investors and companies building new industries. Ex-Kazaa CTO. Main Sequence.

Sydney
Joined September 2006
Deep tech rarely fails on the science. It fails on coordination. A new industry needs founders, investors, corporates and governments to move together, often across countries. That's what I love to talk about here. If you're building one, say hi.
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Deep tech needs wartime investors.
Small funds vs large fund, incentivized by fees vs carry, specialists vs generalists...this is all VC gobbledygook. I wrote a short essay on how this might look from founders' perspective as they choose how to build their cap table in stages. And who to bring on as investment partners. open.substack.com/pub/redgla…
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Tomorrow, I’m joining the inaugural Australia–Japan Leadership Dialogue, bringing together leaders from government, business, academia and civil society to talk about regional, economic and energy security. I’m there as a deep tech investor, and here’s why I think Japan matters. Australia has always produced world-class science. What we struggle with is the next step – turning research into industries that last. That takes manufacturing capability, customers and partners who’ve done it before and are in it for the long haul. Japan has those things, and increasingly it wants to build with us. I am also grateful to Treasurer Jim Chalmers for mentioning Sakura at AJBCC. It’s our proposed Japan–Australia deep tech growth vehicle that we’re collaborating with Daiwa Corporate Investment toward forming. @MSeqVC relationship with Daiwa goes back to 2021, and in the 50th year of the Basic Treaty, it feels like the right time to build something durable. The ideas I’m taking into the room: connect our research base to Japanese industry earlier, and treat this as a two-way corridor, not a one-off deal. Looking forward to the conversation. If you’re building deep tech in Australia and thinking about Japan, we’d love to hear from you.
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Some places are peaceful in every atom. And some are not. The vibe in the inner suburbs of Tokyo reminds me of Amsterdam. Calm, quiet life going on. Every building using space well on a tiny footprint. A pride and unique style decorating each home.
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I’m reading the new @FukuyamaFrancis book - In the Realm of the Last Man. Like many I got ‘The End of History’ wrong and assumed it was a future nirvana without conflict. Sadly the idea is that people, in the end, don’t want to be equally prosperous. We want to be better. We want to make history. We get bored if life has no edge. At least some do. I suggest this does not bode well for those imagining a Star Trek future with Universal Basic Income.
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I’m going to try this next week. Sounds marvellous.
📚 Au Japon, des gens vont désormais en boîte de nuit… pour s’asseoir silencieusement et lire un livre pendant qu’un DJ joue de la musique d'ambience. Le concept s’appelle JUCY BOOK RAVE et se déroule notamment dans un club souterrain de Shimokitazawa, à Tokyo. Ici, pas besoin de danser ni de hurler pour parler à la personne située à 30 centimètres de vous. Les participants viennent avec un livre, s’installent dans la pénombre et lisent pendant que la musique accompagne leur soirée.
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There are too many sovereign industry conversations happening in 'middle power' countries that are sub-scale. If a country really imagines new factories that it builds alone, then have an answer to who pays for the $100M-$1B FOAK facilities. Or collaborate. If a country wants a space industry, can it possibly compete with NASA and SpaceX? Or should it collaborate with countries with a common view and complimentary contribution? We just don't have the heft on our own. Let's not make the era of sovereignty one that starts projects which cannot be finished.
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For new powers that we now have with agentic workflows and software development to migrate to the physical world, we need more venture capital paying attention to hardware, manufacturing, supply chains, capex. Not just paying attention, but getting excited about it and learning the principles which are different from software. Who are the folks that understand this? These folks seem to understand, but who else? @AdamDraper @AdamSharkawy @Avidan @BraytonKey @CleanVC @DakinSloss @E_Bruxxx @IanRountree @KTmBoyle @LuisaSucre @SamirKaul1 @ScottCHsu @WalvanLierop @alancui @borisjabes @caitlinbolnick1 @claydumas @davidu @haomiaoh @hardimanjames @jamiegull @ktrae @lpolovets @luisdarbulu @mattocko @pronounced_kyle @reedsturtevant @robleclerc @schrep @sclarsic @sethbannon @shaunmmaguire @shawnxu @traestephens @vkhosla @wolfejosh @zackbogue @zalzally @zebulgar
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“The harder transition is from attention to excitement, from excitement to belief, and eventually from belief to commitment. And this is where having the proof of partners who have co-invested in your vision with you becomes priceless.” My podcast with Matt Jones at Storywork. youtube.com/watch?v=31wEJRx9…
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This is why I leap out of bed every morning. @v_vongsouthi co-founded @samsara_eco with us to point her PhD at infinite plastic recycling. 5 years later we are building a huge facility that will bring a very real solution to the world. Have a listen to this inspiring young leader and get a dose of hope for the future. Always love the @messaginglab Grow Everything pod @karlschmieder open.spotify.com/episode/0i6…
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Time to start another Venture Science company like @V2FoodOfficial and @samsara_eco and I need your help. What problem do you think will be 10x worse by 2035? And what frontier science should already be solving it... but isn't? Answer those two questions and we'll build you a venture thesis on the spot. venture-science-intake.verce…
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Many inspiring ideas coming in - thank you! Here's some. A bacterial infection gets diagnosed in sixty seconds, not two days. Your gut contains species your grandparents had but you lost to antibiotics and processed food. Your wearable tells you what your body needs before you feel the deficit. Desalination costs a fraction of what it did, because someone worked out how to remove the energy problem. The AI infrastructure that was supposed to consume the grid turned out to generate its own power from osmotic pressure and recycle its own heat. And the synthetic content flooding the internet didn't win, because human judgment became a verified signal the system learned to trust. Keep the ideas coming! venture-science-intake.verce…
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Phil Morle 🖖🏻 retweeted
MEMORY IS THE MOAT @nikesharora, Chairman & CEO of @PaloAltoNtwks , interviewed by @HarryStebbings (@20vcFund ) Summary: Nikesh Arora took Palo Alto Networks from an $18 billion company to one worth $225 billion, and his read on enterprise AI is blunt: most companies are doing it wrong, and most of the products are not ready. His core claim is that consumers forgive AI's mistakes while enterprises cannot, so the money will flow to whoever builds the depth (the context, the memory, and the edge-case training) that lets an agent act without a human catching its errors. The companies that win will redesign themselves around AI instead of adding it to yesterday's workflow, and the lasting advantage will be the memory a system builds up about you. He expects token prices to fall 90%, half of G&A roles to disappear in 3 years, and more engineers and salespeople, not fewer. 1. Context Stickiness. The lasting advantage in AI is the context a system holds about you, not the model itself. Arora says the frontier labs are racing to remember what you asked over the last 30, 60, 90 days so each new answer gets easier and you stop wanting to leave. The more a model knows about a user, the higher the cost of switching, and that stickiness is the moat. For enterprises the same logic holds: the company that owns its context wins, not the one renting the smartest model. 2. Breadth Versus Depth. The frontier model problem is a breadth versus depth problem. Consumers tolerate false positives and enterprises have none to spare. Arora had Gemini write a passable investment memo in 4 minutes, and a wrong line or two did not matter because a person was sitting in the middle to catch it. An agent acting on its own has no person in the middle, so a false positive becomes a live failure. Consumer AI wins on breadth and brand, while real enterprise revenue comes from depth. 3. The Waymo Standard. Waymo is the biggest agentic product in the world, and it shows what depth actually costs. Replacing one human, the driver, took tens of billions of dollars of edge-case training and data that exists nowhere on the internet. You cannot drop the next Anthropic model into your Mercedes and tell it to drive you home. Every enterprise agent that truly replaces a person needs that same depth, which is why most agentic enterprise products are not ready. 4. Rethink The Workflow. Most enterprises are losing because they add a little AI to an old workflow instead of redesigning the workflow around AI. Arora's example: scanning an invoice 20% faster is the trap, while the real win is letting AI do 80% of the thinking, like reading every CV and telling you which 20 people to interview and what to ask each one. That means giving up human control, which is exactly what companies resist. The winners over the next 3 years rethink the company with AI, not the task. 5. Software With Opinions. The next wave of enterprise software will have opinions, and that is the real change Arora is pointing at. Coded SaaS gives you the output you defined for the input you fed it. An AI marketing assistant reads your copy, tells you it is off-brand, and says how to fix it. That opinion makes an average employee smarter, which is why Arora expects half the people in G&A functions like marketing, finance, and HR to be gone within 3 years. 6. More Engineers, Not Fewer. The fear that AI shrinks headcount is half wrong. Process-heavy G&A roles compress, but Arora wants more technical and more sales people. His teams keep asking for resources to rework marketing and HR, and for people who can prompt frontier models, build harnesses, and bring in data nobody else has. A good product also needs more sellers: he met 20 customers in Europe last week and half did not know what his 20-year-old company already ships. 7. Tokens At One-Tenth. Long-term token pricing should be a tenth of what it is today. Compute costs 2 to 4 times what it did 2 years ago because more than half of it feeds loss-making consumer AI, which forces the pricing pressure onto enterprise and coding workloads that have to pay. As compute gets more efficient and consumer usage gets capped, prices fall hard over the next 3 to 5 years. The model from 2 years ago was already good enough for 90% of tasks; the problem was it cost too much to run. 8. The Token Allocation Trap. Capping token spend punishes your best people. Arora runs a "use judiciously" model, not a free-for-all, because the smartest AI-savvy employee can burn 20 times the tokens of an average one. Playing whack-a-mole with cost hurts the high performers most and slows the learning you need. The better move is to track usage, leave the power users alone, and cap only the genuine outliers. 9. The Attacker's New Edge. Powerful coding models cut both ways. Trained to write good code, they are just as good at finding bad code. Pointed at his own systems, a model found in 6 weeks what would have taken his team 5 to 6 years. It cannot safely auto-patch, because it would "fix" 30% of things that are not broken, so it arms attackers faster than defenders. The result is urgency: every enterprise has to fix its systems faster, which is good for security companies. 10. The FTE Tell. If a startup needs forward-deployed engineers to sell into the enterprise, the product is not finished. Arora's read: enterprise AI is barely 12 months old, agents keep changing what the product even is, so vendors send engineers to build the product inside the customer while the technology keeps moving. A real forward-deployed engineer brings code back and folds it into the product; many are just adoption consultants. Expect customers to churn from one tool to the next, the way coding went from Windsurf and Devin to Codex, Claude, and Factory. 11. Three Missed Tricks. Miss one trick and you survive, miss two and you are partly impaled, miss three and you could be obsolete. This is why Arora spends more time than ever learning, pinging founders building things he does not yet understand. He buys early and cheap on conviction, treating an acquisition as a 10x or 100x bet where paying 1 or 2 times more does not matter, rather than waiting to buy the proven winner for a billion. He runs a twice-weekly "AI EIO" meeting so his top 15 leaders compete to show what they shipped. 12. The Sunk Cost Walk. A board member taught Arora to separate effort from wanting the outcome. After months grinding through a near-billion-dollar acquisition, he was told to take a long walk and ask one question: if this deal walked in the door right now with zero effort, would I still write the check? You have not spent a dollar yet, so the only thing that counts is whether it stands on its own merits. The same trap catches investors who confuse beating 8 VCs to a term sheet with the deal being good.
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Love this perspective. There are so many new things to build that are worthy of this posture.
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I hope this happens more in venture capital. We're collectively shoving AI onto brittle infrastructure from a different time. Venture is well placed to get these new physical systems off the ground. The new industrial revolution countries are talking a lot about will not happen without it. Thank you @shaunmmaguire for leading the way.
Most of @sequoia went on a hardware trek to LA this week We visited @reflectorbital @Nominal_io @Mach_Industries @neros_tech (we got a drone show; last photo) @K2SpaceCo @VardaSpace @GoToImpulse (And more) The ecosystem is buzzing HARDWARE IS BACK, baby 🚀
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We’re hiring! Join the team architecting Australia’s next generation of deep tech. 🚀🇦🇺 At Main Sequence, we don’t just wait for the future to happen — we journey into the lab to help build it. We are looking for two Investment Managers to join our team at the intersection of planetary-scale challenges and frontier science. We are looking for dual-language thinkers: those who can navigate a research lab one hour and a boardroom the next. You’ll be tasked with hunting for breakthroughs across our core challenge areas, from decarbonising the planet to bridging the gap to space. We are hiring for two distinct focuses: 🔭 Space & sovereign capability: Deepening our work in orbital infrastructure and dual-use technologies that strengthen national resilience. 🌱 Planetary challenges: Sourcing and scaling the next leaps in healthcare, food, and industrial productivity. If you’ve spent your nights obsessing over the future of humanity and your days thinking about how to bridge the gap between the lab and the launchpad, we want to hear from you. Link in comments.
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Not sure what to think about this.
🚨WHAT META JUST DROPPED IS MORE DANGEROUS THAN ANYTHING OPENAI HAS EVER BUILT!!!!! while everyone was losing their mind over Claude Mythos.. Meta dropped something that nobody noticed.. they built an AI called TRIBE v2.. it's basically a digital copy of your brain.. you show it a video, a sound, a sentence.. and it already knows how your brain is going to react.. 70,000 different parts of your brain.. blood flow, oxygen, everything.. they trained it on 1,000 hours of brain scans from 700 real people lying inside MRI machines.. it doesn't read your thoughts.. it does something worse.. it knows what's going to make you feel something before you even feel it.. think about that for a second.. if an AI already knows which image, which sound, which word is going to hit your dopamine.. you don't need to read someone's mind.. you just build the perfect trap.. and meta didn't even keep it locked up.. they open-sourced it.. gave the code, the weights, everything to the entire world.. this is the same company that got caught making instagram destroy teenage girls.. the same company whose own research said their algorithm pushes rage because rage keeps you scrolling.. that company now has a working copy of how your brain responds to everything you see and hear.. they don't have to guess what keeps you glued to the screen anymore.. they can rehearse it on a copy of your brain before you ever see it.. the product was never the app.. the product was always you.. now they have the blueprint.
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Disagree with this. It is much easier, and not necessarily true, to comment on enemies than it is to comment on friends.
"I never trust what people say about their friends. I trust what they say about their enemies." @nntaleb
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