Our group conducts research into innate immune systems in the brain, in both health and disease, spanning embryonic Neurodevelopment to adult Neurodegeneration
Brisbane, Australia
Joined September 2020
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NeuroComplement_Lab retweeted
Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors dlvr.it/TTN919
NeuroComplement_Lab retweeted
Thrilled to share our latest paper out in @PNAS! ๐งฌ Weโve uncovered the structural basis of how a promising immunostimulant lead candidate activates the complement anaphylatoxin receptor. Huge congratulations to the whole team!๐
pnas.org/doi/10.1073/pnas.26โฆ
A fantastic collaboration on this milestone project. Congratulations to Xaria Li and Joshua Dent who led the work from the laboratories of Richard Clark and myself at UQ.
Our new tool: R8Y is the first selective full agonist for human C5aR2. ๐@FightMND for funding support.
Delighted to share our paper on signaling-bias at the complement anaphylatoxin receptors now published in @MolecularCell! 1/n
Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors: Molecular Cell cell.com/molecular-cell/fullโฆ
Excited to share a comprehensive review by Dr. Xaria Li on the rapidly evolving field of #ComplementTherapeutics, now out in Pharmacological Reviews! With 12 approved drugs across 8 indications (8 since 2022!), this is a resource not to miss @PharmacolRes
authors.elsevier.com/c/1lS9aโฆ
Attending Complement Down-Under (ICW2025) and looking to extend your stay pre- or post-meeting?
Check out these great Queensland road trips: queensland.com/au/en/plan-yoโฆ
Late-breaking abstracts and rego are still open: icw2025brisbane.au/
Last chance to take advantage of the Early-Bird registration deadline for ICW2025 (June 1st 2025). Late-breaking abstracts: July 1st.
Looking to extend your stay pre- or post-meeting? Check out these great Queensland itineraries: queensland.com/au/en/plan-yoโฆ
#ICW2025 #Queensland
๐ฎ๐ฌ๐ฎ๐ฑ ๐๐ป๐๐ฒ๐ฟ๐ป๐ฎ๐๐ถ๐ผ๐ป๐ฎ๐น ๐๐ผ๐บ๐ฝ๐น๐ฒ๐บ๐ฒ๐ป๐ ๐ช๐ผ๐ฟ๐ธ๐๐ต๐ผ๐ฝ
* ๐๐๐ฆ๐ง๐ฅ๐๐๐ง ๐๐๐๐๐๐๐ก๐ ๐๐ซ๐ง๐๐ก๐๐๐ * ๐๐ฝ๐ฟ๐ถ๐น ๐ญ๐ฐ๐๐ต
Join us '๐๐ฐ๐ธ๐ฏ ๐๐ฏ๐ฅ๐ฆ๐ณ' in Brisbane, Australia {Sept 14-19}
#complement #ICW2025
More info and rego complement.org/icw-2025
Excited to be hosting the International Complement Workshop in Brisbane! Join us from Sept 14th-19th for cutting-edge complement science and unique Australian experiences. Submit abstracts by March 14! More info: complement.org/icw-2025 #ICW2025 #ComplementScience #Complement
NeuroComplement_Lab retweeted
๐ขโจAttention ECCO members!
Applications for 2 exciting ECCO opportunities during theย EMCHD Meeting in Lรผbeck are now open! Apply for the Science Slam and/or PhD Journal Article Award (deadlines May 31st and June 30th) using links in the comments! ๐ Don't miss out - apply now!!
NeuroComplement_Lab retweeted
Exciting news! (1/2)๐ขโจ We are now accepting applications from Early Career Complementologists to participate in the "Science Slam" at the upcoming EMCHD meeting! This event, organized by ECCO, will allow two selected participants to share their work and win 500โฌ each.
NeuroComplement_Lab retweeted
The Eph/ephrin pathway is a core driver of vascular leak and endothelial damage in #sepsis but can be targeted effectively with an Eph decoy, show new experiments involving mice and samples from hospitalized children. @neurocomplement @UQMedicine scim.ag/6JF
Excited to share our work in @ScienceTM developing a new treatment approach for sepsis. We targeted the vascular endothelium by inhibiting Eph-ephrin interactions with EphA4-Fc, which reduced vascular leak, inflammation, and mortality in septic mice tinyurl.com/4r72e8aa
NeuroComplement_Lab retweeted
Complement(ing) long-COVID thromboinflammation and pathogenesis dlvr.it/T5fJDp #immunology
NeuroComplement_Lab retweeted
The first Legacy award for Complement Research was awarded today to Piet Gros by the @ComplementSoc International Complement Society at an online symposium in his honor.
We celebrated his amazing contribution to the Structural Biology of Complement.
Congratulations ๐ Piet!
1/3 Excited to share our latest research by the talented Dr Xaria Li on cell-intrinsic C5a in pathogen sensing and fungal killing. Out now in PNAS @PNASNews pnas.org/doi/10.1073/pnas.23โฆ
2/3 Xaria demonstrates human macrophages respond bidirectionally to C5a in synergy with a multitude of pathogen molecular triggers. Surprisingly, non TLR PRRs show the greatest enhancement of cytokine release with C5a receptor activation (eg. Dectin-1 / cGAS-STING)
3/3 Our data support the outstanding work of @LionakisLab Could this cell-intrinsic complement response be harnessed using therapeutics to fight infection? We are embarking on this question now @JohnDGLee @JennyNFung @UQMedicine