@mitchell_lab

Cell & Systems Biology, @UofT, Genome Folding, Enhancer Function, Stem Cells

 Toronto, Ontario
mitchell.csb.utoronto.ca/
Joined November 2016
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New results now online, JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium. An important contribution by Nawrah Khader to our understanding of pregnancy and how the uterus transitions to a laboring state. biorxiv.org/cgi/content/shor…
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Career achievement unlocked - two publications come out on the same day! Great collaboration with Tom Sexton doi.org/10.1126/sciadv.adq09… And fantastic work by Tiegh Taylor and Mitchell lab colleagues journals.plos.org/plosgeneti…

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

science.org
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Out now in @ScienceAdvances 👇 science.org/doi/10.1126/scia… A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

science.org
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Don’t miss this view in December! There is still time to register to attend the 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference Dec 12-15, 2024, in Pacific Grove, CA. asilomarchromatin.com #AsilomarChromatin
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Can’t miss “#Histone Protein Interactions in Health & Disease” presented by keynote speaker Eric I Campos @MoGen_Grad @UofT @SickKidsNews @ the 2024 #AsilomarChromatin Conference Dec 12-15! Register now! Abstracts due Oct 15 #epigenetics #chromatin asilomarchromatin.com
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Register now to see keynote speaker, Dr. Adrian Erlebacher @UCSF @immunox, at the 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference Dec 12-15, 2024! Abstracts due Oct 15 asilomarchromatin.com #AsilomarChromatin #ImmuneTolerance #pregnancy
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Attend the 2024 #AsilomarChromatin Conference Dec 12-15! Keynote speaker @majuarcaa @QueensUBio @queensu will present "Cancer histone mutations disrupt function through shared and unique mechanisms." Abstracts due Oct 15. Register online asilomarchromatin.com #cancer #histone
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Don’t forget to register for the 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference Dec 12-15, 2024! We are excited to have you present your work! Abstracts due Oct 15 asilomarchromatin.com #AsilomarChromatin
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12 days until the Oct 15 ABSTRACT DEADLINE for the 2024 #AsilomarChromatin Conference on Dec 12-15! Keynote speaker @AVogelCiernia @UBC will present on“Epigenetic Control of Microglial Innate Immune Memory.” asilomarchromatin.com #epigenetic #microglia #Innate_Immune
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Excited to announce Dr. Annie Vogel Ciernia @AVogelCiernia @UBC will join us as a keynote speaker for 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference Dec 12-15, 2024! Join us! Abstracts due Oct 15 asilomarchromatin.com #AsilomarChromatin
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Thrilled to share Dr. Maria J Aristizabal @majuarcaa @QueensUBio @queensu is a keynote speaker for the 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference Dec 12-15, 2024! Join us! Abstracts due Oct 15 asilomarchromatin.com #AsilomarChromatin
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Thanks to Dr. Eric I Campos @MoGen_Grad @UofT @SickKidsNews for joining us as a keynote speaker! 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference Dec 12-15, 2024! Register now! Abstracts due Oct 15 asilomarchromatin.com #AsilomarChromatin
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TICK-TOCK, TICK-TOCK!! Remember to register for the 46th International Annual Asilomar #Chromatin, #Chromosomes, & #Epigenetics Conference by Sep 15 to save $$$! Be there Dec 12-15, 2024, in Pacific Grove CA! Abstract deadline is Oct 15 asilomarchromatin.com #AsilomarChromatin
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Excited to announce the 46th International Annual Asilomar #Chromatin, #Chromosomes, and #Epigenetics Conference is happening Dec 12-15, 2024, in Pacific Grove, CA! Save $$ when you register by Sep 15!! Abstract deadline is Oct 15. asilomarchromatin.com #AsilomarChromatin
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Interested in the sequences that control lineage commitment and region specificity of NSCs? Come to poster 263 at 3:45 today to see A SOX2 ENHANCER CLUSTER REQUIRED FOR THE ANTERIOR REGIONAL IDENTITY OF NEURAL STEM CELLS #ISSCR2024
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Registration is now OPEN for the 10th Annual Canadian Conference on Epigenetics taking place in Blue Mountains, ON from Oct 1-4, 2024! Travel awards and childcare/disability subsidies are available to eligible applicants, so please apply! event.fourwaves.com/ceehrc20…
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New data on how genes in the same TAD are independently regulated by separate enhancers biorxiv.org/content/10.1101/…

THE CELLS ARE ALL-RIGHT: Regulation of the Lefty genes by separate enhancers in mouse embryonic...

Enhancers play a critical role in regulating precise gene expression patterns essential for development and cellular identity; however, how gene-enhancer specificity is encoded within the genome is...

biorxiv.org
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Using CRISPR deletion we discovered that the Lefty paralogs are each regulated by separate enhancers despite being located within the same TAD.
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Thank you all for attending our workshop on Effective Science Illustration by Martin Krzywinski @MKrzywinski! We hoped you picked up some great pointers to use when thinking about your next figures! For those who missed it, you can find it here: youtu.be/WKqQM5kgULg

Effective Science Illustrations

A workshop presented by the CEEHRC Trainee Committee on June 13, 20...

youtube.com
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Join us on June 13th at 11am PDT for a workshop on Effective Science Illustrations with Martin Krzywinski. The workshop will be held in person in UBC with live viewing nodes and online attendance also available. For more information & registration go to: shorturl.at/aOwQi
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Don't miss the last @CSMB_SCBMseminar of this terms! Next Tuesday (June 4) at 9am PT/12pm ET! We'll hear from Dr. Mitchell (@mitchell_lab) and Dr. Dixon (@CharnealD) from @gfairn's lab. Don't miss out 🧪🔬🧬 Sign up here: zoom.us/j/99672076008
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