@mingda_ye

Solute Carriers, Structural Biology

 Oxford, England
Joined May 2022
  • Tweets17
  • Following23
  • Followers11
Our study of the CAT1 amino acid transporter and viral receptor is now online in @NatureComms! Led by the incredibly talented @mingda_ye, with colleagues from @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, @NDMOxford, and supported by @im2pact_project nature.com/articles/s41467-0…

Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus...

Nature Communications - Cationic amino acids are essential to protein synthesis and cellular signaling. Here, authors determine the structure of the cationic amino acid transporter 1 and determined...

nature.com
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Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer doi.org/10.1021/acscentsci.5…

Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody...

Abstract. Design of modular, transferable protein assemblies has broad applicability and in structural biology could help with the ever-troublesome crystal

pubs.acs.org
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Very successful (and fun) group picnic. Thankfully the very English weather was accommodating! Thank you @GL_Isom for joining!
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Mingda's work resolves major details of CAT1 function - Selectivity and transport for amino acids Arg, Lys, Orn - Friend Murine Leukemia virus binding to MmCAT1 with nM affinity yet having narrow host tropism
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Cationic amino acid transport and viral binding of MmCAT1 Fantastic work by @mingda_ye and colleagues at @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, and the @im2pact_project researchsquare.com/article/r…
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New paper submission by the incredibly talented @mingda_ye and colleagues at @CmdOxford @OxfordStrubi @CAMS_COI_Ox Preprint coming soon!
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Our Director of Protein Biochemistry & Structural Biology @katharina_duerr will be presenting at Gordon Research Conferences’ ‘New Insights into Structure, Function, and Regulation of Critical Membrane Transport Proteins in Health and Disease’ conference. grc.org/membrane-transport-p…
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CryoDRGN-ET❄️🐉 is published in @naturemethods! We combine neural fields and generative modeling to reveal the structural heterogeneity of protein complexes *in situ*! So excited to see this out, and huge congrats to @ramyarangan, @FeathersRyan and team! nature.com/articles/s41592-0…
Ellen Zhong
@ZhongingAlong21 Aug 2023
What do dynamic protein complexes look like *inside the cell*? Excited to share our work, led by superstar @ramyarangan, on cryoDRGN-ET, a new approach in the ❄️🐉 software for reconstructing and visualizing structures from in situ cryo-ET data. 1/ biorxiv.org/content/10.1101/…
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Really excited to be here at the 2024 structural biology meeting at Tsinghua University, with Prof Yigong Shi kicking off the meeting.
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Congratulations to Prof Peijun Zhang from NDM's Division of Structural Biology and @DiamondLightSou for being elected to @EMBO membership 👏🎉 Find out more 👉 ndm.ox.ac.uk/news/peijun-zha…
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Collaboration in Action: Academic-Industry Stories In his story, Benedikt Kessler @NDMOxford shares how collaborating with industry has driven breakthroughs in ubiquitin biology research. #CollaborationInAction Read Benedikt’s story: medsci.ox.ac.uk/for-staff/re…
Benedikt Kessler, Professor of Biochemistry and Mass Spectrometry, alongside the quote "Working with industry proved indispensable to advancing the field of ubiquitin biology research and to exploring translational opportunities. Moreover, this alliance also paved the way for further industry collaborations."

ALT Benedikt Kessler, Professor of Biochemistry and Mass Spectrometry, alongside the quote "Working with industry proved indispensable to advancing the field of ubiquitin biology research and to exploring translational opportunities. Moreover, this alliance also paved the way for further industry collaborations."

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David and I wrote a quick Preview for @Structure_CP to provide some context around the fantastic recent Pho90 work by @Oezkan_YildizZ and colleagues! cell.com/structure/abstract/…
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And it's out! Structure and function of the proline transporter SIT1 in complex with ACE2 Congrats to Huanyu, Ashley, Irina, @robertvandenbe2, Liz Carpenter, @T_dafforn, and the many other collaborators from @CmdOxford, @uobbiosciences, @Sydney_Uni nature.com/articles/s41467-0…

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

Nature Communications - The SIT1-ACE2 complex transports the amino acid proline and is the receptor of SARS-CoV-2. Here, the authors identify specific sequence requirements for proline transport...

nature.com
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Dimerize nanobodies to duplex data collection AND determine structures of small targets! biorxiv.org/content/10.1101/…
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Replying to @DavidBSauer @GroupZhang @FrankvonDelft @CarriqueLoic @EmmitLi @OxfordStrubi @PharmOxford @DiamondLightSou @eBIC_Diamond @CmdOxford
Very cool new strategy for solving small proteins by cryo-EM! Testing different hetero/homoDi-Gluebodies may also help against problems with prefered orientation. Congrats! Here is the sister preprint about Gluebodies for enhanced crystal reliability: biorxiv.org/content/10.1101/…

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that...

The design of proteins that may assemble in a manner that is transferable and modular remains an enduring challenge. In particular, obtaining well-diffracting protein crystals suitable for characte...

biorxiv.org
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A wonderful collaboration of @GroupZhang, @FrankvonDelft, @katharina_duerr, @CarriqueLoic, @EmmitLi, @OxfordStrubi, @PharmOxford, @DiamondLightSou, @eBIC_Diamond, and @CmdOxford
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