Membrane Transporters, Ion Channels, Structural Biology, Bioinformatics... and other bits of fun Purdue BS, UTSW PhD, NYUSoM PostDoc, Univ. of Oxford PI
New York, NY
Joined February 2018
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Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)!
By the inexhaustible and tenacious @Anna_Liiiiiiii
in collab of @CMS_CDG_Oxford in @MRC_WIMM and @CmdOxford
cell.com/star-protocols/full…
New publication for SLC13A5 targeting compounds! Discovery of the BI chemical probe is out now in J. Med. Chem.
Great work by Andrew Quigley, Liz Carpenter, and colleagues from Oxford's @CmdOxford, @Boehringer, and @thesgconline
pubs.acs.org/doi/10.1021/acs…
In another case of transporters doing more than you expect: SPNS2 is a glucose importer, in addition to its S1P export activity!
Wonderful collaboration with Sarah Spiegel and colleagues at VCU School of Medicine, and the team at @CmdOxford
nature.com/articles/s41467-0…
Our study of the CAT1 amino acid transporter and viral receptor is now online in @NatureComms!
Led by the incredibly talented @mingda_ye, with colleagues from @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, @NDMOxford, and supported by @im2pact_project
nature.com/articles/s41467-0…
David B Sauer retweeted
New work out today in PNAS!
Secondary active transporters are everywhere, but direct observation of their structural dynamics is rarely achieved.
Here, we capture the real-time dynamics of a sodium-coupled dicarboxylate transporter using smFRET.
🧵⬇️
doi.org/10.1073/pnas.2500723…
David B Sauer retweeted
Thrilled to submit another paper with Yin Yao Dong @CMS_CDG_Oxford and @DavidBSauer 🥳🥳🥳 ✍🏻✍🏻✍🏻🦠🦠🦠 (📸photo credit: Claudia Burn-Leefe)
David B Sauer retweeted
Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci
Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer
doi.org/10.1021/acscentsci.5…
Closing soon!
Please apply if you are interested in targeting membrane proteins with new therapeutics!
Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!!
Happy to chat about any questions about the role and science.
Oxford will assist with a skilled worker visa.
Please RT!
my.corehr.com/pls/uoxrecruit…
Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!!
Happy to chat about any questions about the role and science.
Oxford will assist with a skilled worker visa.
Please RT!
my.corehr.com/pls/uoxrecruit…
I'm far more active on the Bluesky platform, if you want to find me there
bsky.app/profile/davidbsauer…
David B Sauer retweeted
First keynote of the day from @DavidBSauer #bcium2025 …before coffee and chocolates from @DECTRIS_News @ccp_em @ccp4_mx @instructhub
Another year, another mess with canceled flights. 🤬
@VirginAtlantic - Flight canceled txt, but we'll automatically rebook you.
- (I called after silence) We subcontracted the flight; you must sort out with @Delta
New plan: already delayed flights have no further hiccups AND fast passport control.
Trying to be hopeful 😬
Gratitude to @VirginAtlantic customer serv. for coming up with a plan
Cheeky visit to @unisabana during a family trip! Spectacular campus in the Colombian Andes
Thank you @NuryOlaya2 for a great discussion and showing us around!!
Just finished our "State of the Group" talk in lab meeting
2024 Recap
- 9 papers published
- 6 papers in review
- 2 DPhils
What's next
- More papers in flight, landing soon
- Expand our toolbox and biomed relevance
Another year of great pride in our team!
Two highlights of 2024 contained in one photo 😀
Titled "First CNS submission of a newborn (aged 4 days)"
Alternative title "Type VERY quietly!"
ALT First CNS submission of a newborn (aged 4 days)
I should add one great sadness of last year, losing our colleague @sagaraturi
An energetic and passionate scientist gone too soon
Now online! @Anna_Liiiiiiii fantastic work on the structure of the Human adult Muscle-type nicotinic receptor.
Wonderful collab with @CMS_CDG_Oxford at the @MRC_WIMM and @CmdOxford
biorxiv.org/content/10.1101/…
And a parallel study on human muscle-type AChR by @RyanHibbs10 and colleagues!!
Wonderful to see that we agree on many points, while also making distinct and novel discoveries on AChRs in myasthenia gravis
biorxiv.org/content/10.1101/…