Postdoc in @METorresPadilla Lab. Studying TEs in early development. PhD in @dekker_lab @UmassMedical. (also @marliesoomen.bsky.social)
Joined September 2012
- Tweets66
- Following273
- Followers291
- Likes401
Marlies Oomen retweeted
Pathway to Independence – an interview with Marlies Oomen
In this interview, @meoomen talks about her plans for her future lab and her hopes for the Pathway to Independence (PI) programme
journals.biologists.com/dev/…
Marlies Oomen retweeted
Our next #DevPres webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller @AnzyMiller and Marlies Oomen @meoomen, chaired by James Gahan @JM_Gahan.
📆 27 August, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi…
ALT Development presents… Wednesday 27 August 15:00 BST Chair: James Gaham Anzy Miller (University of Manchester) ‘NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation’ Marlies Oomen (Helmholtz Munich, Institute of Epigenetics and Stem Cells) ‘Jumping through evolution; Genome regulation of and by transposable elements during mammalian preimplantation development’ #DevPres | @dev-journal.bsky.social thenode.biologists.com/devpres The Company of Biologists logo Development
Marlies Oomen retweeted
Now online! An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development dlvr.it/THTChb
Marlies Oomen retweeted
Suuuuuuuper excited to see our work on the transcriptional dynamics of TEs across mammalian embryos finally out on @CellCellPress !
Short version: from rabbits, to cows, to pigs, to mice and even monkeys... TEs of all classes and ages are transcriptionally activated at ZGA ⚡
Very excited that our paper is now online! cell.com/cell/fulltext/S0092…
Long thread on our findings on the other app 🦋
Very excited that our paper is now online! cell.com/cell/fulltext/S0092…
Long thread on our findings on the other app 🦋
Ancient Viral DNA Shapes Early Embryo Development
Researchers at #HelmholtzMunich & @LMU_Muenchen have uncovered the crucial role of transposable elements— ancient viral #DNA remnants— in early embryo development:
👉t1p.de/pb7sc
Key insights:
🌟Ancient viral DNA, once thought to be extinct, is reactivated during the first stages of embryonic development across mammalian species.
🌟Each species expresses distinct transposable elements, which influence cellular plasticity and gene regulation.
💡This discovery opens new possibilities for manipulating cell fate and advancing stem cell research.
💬“Our findings highlight how understanding these elements can revolutionize gene regulation and cellular processes.”
Prof. Maria-Elena Torres-Padilla
@METorresPadilla @epigeneticsHMGU @meoomen @DiegoRTerrones @CellPressNews
#EmbryoDevelopment #Genomics #ViralDNA #StemCells
ALT Ancient Viral DNA Shapes Early Embryo Development
Marlies Oomen retweeted
Maria-Elena Torres-Padilla Awarded the Leibniz-Preis 2025 🎉
👏 The German Research Foundation (#DFG) recognizes the outstanding research of Prof. Maria-Elena Torres-Padilla with Germany’s most prestigious scientific award: the Gottfried Wilhelm #LeibnizPreis.
👉t1p.de/s6uma
💡 The international top scientist from #HelmholtzMunich fundamentally changed our understanding of stem cell biology an early development.
With her groundbreaking "cells à la carte" approach, the Mexico-born scientist is pioneering innovative #therapies for diseases like neurodegeneration, brain injuries, and cancer.
👉Discover more in her #interview "Empowering Cells’ and Scientists’ Potential for Cell Therapies":
🔗t1p.de/tex9p
Prof. Matthias Tschöp, CEO of Helmholtz Munich, states:
💬 "Maria-Elena Torres-Padilla has fundamentally changed our understanding of early development and epigenetic regulation with her groundbreaking contributions to stem cell biology. Her scientific excellence and innovative thinking have had a profound impact on the field and inspires researchers worldwide. The Leibniz Prize is a well-deserved recognition of her exceptional achievements and lasting influence on biomedicine."
🌟 Why it matters:
Her work is not just science - it’s the foundation for future #PersonalizedMedicine and #RegenerativeTherapies.
About Maria-Elena Torres-Padilla:
✨Head of the Stem Cell Center (rotating), Helmholtz Munich
✨Director of the Institute of Epigenetics and Stem
Cells, Helmholtz Munich
✨Director of Biomedicine at @PioneerCampus
✨Professor at @LMU_Muenchen
@METorresPadilla @dfg_public @epigeneticsHMGU @MatthiasTschop
#Epigenetics #StemCells #Award #Research #ResearchPioneers
ALT Prof. Maria-Elena Torres-Padilla Awarded Gottfried-Wilhelm Leibniz-Preis 2025
Marlies Oomen retweeted
Herzlichen Glückwunsch zum #LeibnizPreis! 10 Wissenschaftler*innen gebührt große Ehre. Sie erhalten je 2,5 Mio. Euro für ihre #Forschung. Die Verleihung feiern wir am 19. März in #Berlin – zusammen mit vielen bisherigen Preisträger*innen aus #40JahreGWL. ➡️dfg.de/de/service/presse/pre…
Marlies Oomen retweeted
#JustIn: @UMassChan researcher Victor R. Ambros, PhD, the Silverman Chair in Natural Sciences and professor of molecular medicine, has received the 2024 @NobelPrize in Physiology or Medicine for the discovery of microRNA. #NobelPrize #medicine #BreakingNews #Worcester @ProgMolMed
ALT Congratulations to Nobel Prize winner Victor R. Ambros, PhD, of UMass Chan Medical School
Marlies Oomen retweeted
Looking for a PhD position? Interested in low-input genomics data and computational approaches? Want to live in Rome?:) Look no further! We are recruiting a dry-lab PhD student through the EMBL PhD program. Details: embl.org/about/info/embl-int…
PhD student looking for Neuroscience or Epigenetics labs to join? Apply to the EMBL PhD program! My lab and the labs of @Cornhelix, @hackettlab, and @AnaBoskovic18 are hiring! 1 Application to apply to labs in all 6 EMBL campuses!
Deadline October 14:
embl.org/about/info/embl-int…
Marlies Oomen retweeted
We developed a simple highly-optimized version of 2nd gen Hi-C, called FLIE HI-C, which takes 2 days instead of 4-5, uses 5-20 fold less reagents, and needs only 100-1000 fold less input material. Importantly, we keep all the controls and the interaction map quality is excellent.
Marlies Oomen retweeted
A new review is online!
Marlies Oomen and Maria-Elena Torres-Padilla @METorresPadilla @HelmholtzMunich discuss roles of transposable element co-option in #genome regulation in the early #embryo, #germline, #placenta and embryonic #stemcells.
-> embopress.org/doi/full/10.10…
Marlies Oomen retweeted
Last week, we hosted the 2nd Science & Networking Event to showcase the outstanding work of postdoctoral researchers @HelmholtzMunich!
🙏A big thanks to @AaronNovikoff @meoomen @Mehmet_Goekkaya Johanna Winter & Misako Nakayama for their greats talks!
Marlies Oomen retweeted
It is BACK ! 👇🥳 - following our successful edition in 2022, our Hands-On Summer school is back in 2024-
You'll do wet-work - dry work - learn - interact with leaders in the field - and have fun @HelmholtzMunich
Spaces are limited so apply soon ! 👇
Summer School on Chromatin Biology is back in August at @HelmholtzMunich. Start your journey into state-of-the-art chromatin biology with #epigenetics experts @robert_ife @metorrespadilla and Aloys Schepers – apply by April 5 for the 2024 student cohort. bit.ly/42b8tFc
Marlies Oomen retweeted
Summer School on Chromatin Biology is back in August at @HelmholtzMunich. Start your journey into state-of-the-art chromatin biology with #epigenetics experts @robert_ife @metorrespadilla and Aloys Schepers – apply by April 5 for the 2024 student cohort. bit.ly/42b8tFc
Marlies Oomen retweeted
Very happy of this joint work with @meoomen and @job_dekker.
Not all species fold exactly the same way and not all loop extruders behave the same regarding CTCF. Mitosis really offers unique opportunities to test and understand key molecular questions. Take a look!
What started as a seemingly contradicting observation in mESC and human differentiated cell lines, then became a bonus thesis chapter, is now on BioRxiv! biorxiv.org/content/10.1101/…
What started as a seemingly contradicting observation in mESC and human differentiated cell lines, then became a bonus thesis chapter, is now on BioRxiv! biorxiv.org/content/10.1101/…
(2) When investigating the average mitotic loop length, we found that this is species (and not cell type!) specific. The longer the average q-arm length, the longer the loops that are formed in mitosis.
I am so happy this last chapter (quite literally) of my PhD is on BioRxiv. Big thanks to everyone involved, in particular of course @job_dekker, @pablonavarroLAB and his lab members and @NickiFoxTapper, who confirmed our genomics findings with beautiful microscopy!