@meinusha
Joined February 2020
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  • Followers64
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Checkout our new paper published in @CellRepMed. cell.com/cell-reports-medici… Fantastic work by Meinusha Govindarajan @meinusha and Salvador Mejia-Guerrero with lots of help from our many collaborators and colleagues. #glycotime

Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable...

Govindarajan et al. leverage N-glycoproteomics and PDX models to decode the in vivo cancer cell surfaceome and establish Glyco PDXplorer—a target discovery platform. The identification and validation...

cell.com
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Checkout the latest preprint from @meinusha - the final part of her PhD Surface proteomics reveals arginine metabolism as a vulnerability in high grade serous ovarian cancer biorxiv.org/content/10.1101/…

Surface proteomics reveals arginine metabolism as a vulnerability in high grade serous ovarian...

Background The significant lethality of high-grade serous ovarian cancer (HGSC) is driven by the lack of long-term efficacy of current treatments, underscoring the need for developing additional...

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checkout our latest paper in @NatureBiotech. We developed a graph-based algorithm that comprehensively generates non-canonical peptides in linear time. nature.com/articles/s41587-0…

Identification of non-canonical peptides with moPepGen

Nature Biotechnology - moPepGen enables the detection of peptides across species, proteases and technologies.

nature.com
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Excited to share our first lab paper, now published in @Dev_Cell! 🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?
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CSF protein biomarkers are associated with response to multi-agent intraventricular chemotherapy in patients with CNS lymphoma academic.oup.com/noa/article…

Cerebrospinal fluid protein biomarkers are associated with response to multiagent intraventricular...

AbstractBackground. Central nervous system lymphoma (CNSL), is a rare subtype of non-Hodgkin lymphoma, primarily affecting the brain and spinal cord. Most

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Our study on T-ALL heterogeneity is out! We show ~1/3 of T-ALLs express inflammatory/stem signatures and are sensitive to venetoclax. Huge congrats to @gowerfulScience for leading the way, @s_jahangiri, and the entire team! science.org/doi/10.1126/scit…

An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup

Multiomics analysis identified an inflammatory T-lineage acute lymphoblastic leukemia subtype associated with poor treatment responses.

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Last paper for 2024. Nice work by @mrwaas on proteomics of HNSCC tissues to identify novel biomarkers within the N0 population. Great collaboration with @laillesuhnrese1 and support from many colleagues @PMResearch_UHN
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Big effort (> 7 years) from a large number of colleagues. Finally on BioRxiv and to be submitted in January Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers biorxiv.org/content/10.1101/…

Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as a therapeutic...

Cell surface proteins offer significant cancer therapeutic potential attributable to their accessible membrane localization and central role in cellular signaling. Despite this, their promise remains...

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Nice work by Matt @mrwaas and rest of the team to put this protocol together Protocol for generating high-fidelity proteomic profiles using DROPPS sciencedirect.com/science/ar…
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Proteomics on 800 urine fractions from prostate cancer patients (soluble fraction and EVs). Outstanding work by @amandakhoo4 @meinusha and Zhuyu Qui. It was a long process to get this published nature.com/articles/s41467-0…

Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes

Nature Communications - Urine can be used to easily analyse the health of patients. Here, the authors identify proteins in urinary extracellular vesicles that distinguish prostate cancer from...

nature.com
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Come check out @mrwaas awesome poster on using DROPPS to dissect mammary stem cell heterogeneity at MP 773 @KislingerThomas #ASMS2024
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Congratulations ⁦@mrwaas⁩ for securing the cover for his Dropps paper cell.com/cell-reports-method…
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moPepGen: Rapid and Comprehensive Proteoform Identification pubmed.ncbi.nlm.nih.gov/3858…

Identification of non-canonical peptides with moPepGen - PubMed

Proteogenomics is limited by challenges of modeling the complexities of gene expression. We create moPepGen, a graph-based algorithm that comprehensively generates non-canonical peptides in linear...

pubmed.ncbi.nlm.nih.gov
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Second paper in two days. Great work by @AnnieHahkl and @amandakhoo4 Comprehensive Prostate Fluid-Based Spectral Libraries for Enhanced Protein Detection in Urine | Journal of Proteome Research pubs.acs.org/doi/10.1021/acs…

Comprehensive Prostate Fluid-Based Spectral Libraries for Enhanced Protein Detection in Urine

Abstract. Biofluids contain molecules in circulation and from nearby organs that can be indicative of disease states. Characterizing the proteome of bioflu

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Checkout our new paper, describing a simple method to analyze low amounts of flow sorted cells by @mrwaas and team Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium: Cell Reports Methods cell.com/cell-reports-method…

Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium

Waas et al. develop and validate DROPPS, a proteomic workflow designed to democratize the capacity to profile rare cell populations without compromising data quality. DROPPS generates high-fidelity...

cell.com
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Checkout our new article published in Acta Neuropathologica Communications by former PDF Shahbaz Khan in collaboration with @gelarehzadeh doi.org/10.1186/s40478-024-0…

Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma...

Acta Neuropathologica Communications - Chordomas are clinically aggressive tumors with a high rate of disease progression despite maximal therapy. Given the limited therapeutic options available,...

link.springer.com
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And ⁦@mrwaas⁩ has his poster on rare cell populations (poster 5.159). Come and check it out
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Come and visit ⁦@meinusha⁩ at her amazing poster on glycoproteomics in PDX models (poster 5.53)
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Latest preprint from the lab. A simple method for the proteomics analysis of rare cell populations. Developed by post-doc @mrwaas biorxiv.org/content/10.1101/…

Droplet based low input proteomic platform for rare cell populations

Deep proteomic profiling of rare cell populations has been constrained by sample input requirements. Here, we present DROPPS, an accessible low-input platform that generates high-fidelity proteomic...

biorxiv.org
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Meinusha retweeted
Matt Waas@mrwaas12 Sep 2023
Introducing DROPPS! Here's our preprint that describes an accesible approach to low input proteomics and how we applied it to generate some interesting biological insights (1/x) biorxiv.org/content/10.1101/…

Droplet based low input proteomic platform for rare cell populations

Deep proteomic profiling of rare cell populations has been constrained by sample input requirements. Here, we present DROPPS, an accessible low-input platform that generates high-fidelity proteomic...

biorxiv.org
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