Clinical Proteomics, Cancer Biology & Mass Spectrometry @MBPatUofT and @pmcancercentre 🇨🇦
Toronto, Ontario
Joined March 2019
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Checkout our new paper published in @CellRepMed.
cell.com/cell-reports-medici…
Fantastic work by Meinusha Govindarajan @meinusha and Salvador Mejia-Guerrero with lots of help from our many collaborators and colleagues. #glycotime
Thomas Kislinger retweeted
What happens to the bone marrow niche in #CHIP? We find that CHIP is associated with fibro-inflammatory hubs emerging before the disease.
Co-led by our fantastic @aliciaguilar_ and @gibran_edun
nature.com/articles/s41590-0…
#ClonalHematopoiesis #PreTumorMicroenvironment #Hematopoiesis
Thomas Kislinger retweeted
#ProstateCancer urinary proteome differs by ancestry. 329 men: 194 Black, 135 White
â–¸ 110 proteins differ (adj. age, PSA, grade)
â–¸ Immune pathways most dysregulated
â–¸ Black patients' urine resembled higher-grade disease vs White men
oxford.ly/4hVL82T
@KislingerThomas
Ancestry-Dependent Immunologic and Prognostic Effects Characterize the Prostate Cancer Urinary Proteome academic.oup.com/jnci/articl…
Matt Waas's @mrwaas latest publication using DROPPS proteomics to interrogate the functional diversity of the mammary epithelium in women at high risk of breast cancer now published in Genome Biology. This work was in collaboration with @rmkhokha and funded by @tfri_research
Thomas Kislinger retweeted
CAR T cell therapy eliminates glioblastoma tumours in preclinical study drugtargetreview.com/car-t-c…
Thomas Kislinger retweeted
Govindarajan and Mejia-Guerrero et al. used enrichment of N-glycosylated surface proteins and mass spectrometry to profile 85 patient-derived xenografts and generated Glyco PDXplorer, an in vivo pan-cancer atlas of tumor cell-surface N-glycoproteins. 290 cancer-enriched surface targets with limited normal tissue expression were identified. FAT2 emerged as a novel HNSC-enriched surface protein, essential for HNSC adhesion, growth, and survival via integrin-PI3K signaling. In the BT530 patient-derived model of brain metastasis with squamous cell histology, intracranial administration of FAT2 CAR-T cells reduced tumor burden and extended survival. bit.ly/4tiw4RE  @meinusha  @KislingerThomas
Thomas Kislinger retweeted
@CellCellPress: A Game-changer for biomarker development & targeted therapies. doi.org/10.1016/j.cell.2025.…
#Neuroscience #AlzheimersDisease #Tauopathy #Proteomics #PrecisionMedicine #Biomarkers #Neurodegeneration #CTE #FTD #MassSpec #DrugDiscovery #BrainResearch #CellPaper
New pre-print from the lap by Matt Waas -
Mapping lineage and functional diversity in the high-risk human mammary epithelium biorxiv.org/content/10.64898…
We develop a PDX-based N-glycoproteomics strategy to discover cancer-enriched cell surface targets and identify FAT2 as a novel, largely unexplored squamous cell marker that is essential for cellular growth and survival.
Thomas Kislinger retweeted
Checkout our preprint on integrated proteogenomic analysis of localized prostate cancer @schafer_sci @CPDR_Labs :
biorxiv.org/cgi/content/shor…
checkout our new work comparing CSF proteomics workflows link.springer.com/article/10…
Thomas Kislinger retweeted
Behind the Paper: From mutation to peptide: resolving proteome complexity with moPepGen communities.springernature.c…
Checkout the latest preprint from @meinusha - the final part of her PhD
Surface proteomics reveals arginine metabolism as a vulnerability in high grade serous ovarian cancer biorxiv.org/content/10.1101/…
And in case you missed it here is her other preprint.
biorxiv.org/content/10.1101/…
Checkout our latest pre-print.
biorxiv.org/content/10.1101/…
This cohort was stratified by ancestry – thought to be a risk-factor for aggressive disease. We found surprisingly large differences and dysregulation of immune pathways.