Introducing PINNACLE, a contextual graph AI model for comprehensive protein understanding PINNACLE dynamically adjusts its outputs based on molecular contexts in which it operates Providing outputs tailored to molecular contexts is essential for broader use of foundational models in biology and medicine Leveraging #single-cell atlas, PINNACLE is trained on contextualized protein networks to generate context-aware representations split across 156 cell type contexts from 24 tissues Pretrained PINNACLE protein representations can be adapted for broad array of tasks 🧪enhance 3D structural representations 💊study genomic drug effects across cell type contexts 🎯nominate #therapeutic targets 🌲zero-shot retrieval of the tissue hierarchy Led by a superstar PhD student @_michellemli! Grateful for wonderful collaborators @harvardmed @HarvardDBMI @BrighamWomens @MassGeneralNews @MassGenBrigham @Roche @harvard_data Y Huang @YepHuang, M Sumathipala @marissa_sumathi, MQ Liang, A Valdeolivas, A Ananthakrishnan, K Liao, and D Marbach #AI4Science #SingleCell #AI #Proteins [1/4]