Professor and Clinician, Physiology & Neuroscience, Neurology, Keck School of Medicine of USC, #stroke #ischemia #thrombolytics (account managed by lab members)
Los Angeles, CA 90033
Joined October 2023
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- Following90
- Followers94
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Patrick Lyden retweeted
I had the opportunity to give an oral abstract presentation on our work investigating the role of endothelial protease activated receptor 1 (PAR1) in promoting BBB breakdown after ischemic stroke in #ISC26 in New Orleans last week. Here is the link: ahajournals.org/doi/10.1161/…
Patrick Lyden retweeted
Here is the link to the paper: link.springer.com/article/10…
Patrick Lyden retweeted
Our results indicate that this model still needs further optimization to get reproducible stroke. The results paper from our feasibility study is out in ‘Translation Stroke Research’ journal now. Thanks and congratulations to all coauthors from the Lyden lab and SPAN network.
Patrick Lyden retweeted
To increase translational relevance, we tried to standardize rat thromboembolic stroke model to assess the feasibility for using this model in the Stroke Preclinical Assessment Network (SPAN).
Patrick Lyden retweeted
While thromboembolic stroke model matches more closely with the inflammatory cascades of human ischemic stroke than our popular nylon filament model, it is hard to get reproducible stroke with less mortality in this model.
Patrick Lyden retweeted
I am happy to share that our method paper on optimizing and standardizing the thromboembolic model of stroke in rats for the Stroke Preclinical Assessment Network (SPAN) is online now. Thanks to all colleagues from SPAN and Lyden Lab. Here is the link:
app.jove.com/t/69522/the-str…
Patrick Lyden retweeted
Excited to share the preprint of a manuscript from my PhD work. We showed that delivery of chitosan-based hydrogel into the infarct cavity reduces reactive astrogliosis and promotes the proliferation of neural progenitor cells after stroke. biorxiv.org/content/10.1101/…
Patrick Lyden retweeted
From panels to keynotes to posters, the International Stroke Conference is the place to learn from the best and brightest from around the globe. Be part of the conversation at #ISC26 in New Orleans.
ISC26 Chairs: @LaurenHSansing @bijoymenon
📷 #ISC25
Patrick Lyden retweeted
#STROKE: Fingolimod treatment shows mixed effects on post-ischemic stroke outcomes depending on comorbidities in a randomized, multicenter rodent preclinical trial (SPAN). @sheth_kevin @LD_McCullough @LaurenHSansing #AHAJournals ahajrnls.org/3WgPxTo
ALT Graphic abstract in Boisserand et al.
Another paper from our SPAN 1.0 studies is out in @StrokeAHA_ASA. Fasudil, a Rho-kinase (ROCK) inhibitor, improved the primary outcome (day 28 corner test) in mice. Thanks to the lead author @imai_takahiko and the Ayata Lab. Here is the link. ahajournals.org/doi/10.1161/…
Patrick Lyden retweeted
Calling all stroke researchers and clinicians!! Deadline for invited symposia suggestions for #ISC26 in New Orleans is Thursday, April 3, 2025 at 6:00 a.m. ET! New categories!! Get your ideas into the conference :) @AHAScience @bijoymenon @ShadiYaghi2 @Braindoc_MGH
Patrick Lyden retweeted
Last date for ISC session submissions is tomorrow!!! This is your chance to shape ISC2026! @StrokeAHA_ASA @LaurenHSansing @NguyenThanhMD @ChaturvediNeuro @AHAScience
Patrick Lyden retweeted
We want your ideas! We invite you to submit your exciting and novel session ideas for debate topics, session topics and speakers for #ISC26. This is your opportunity to have your suggestions considered for the next International Stroke Conference!
spr.ly/6018FZz6G
Patrick Lyden retweeted
News: NIH-funded study identifies potential new stroke treatment nih.gov/news-events/news-rel…
Patrick Lyden retweeted
#STROKE: Uric acid supplementation provides cerebroprotection across different animal species, sex, age, and comorbidities. #AHAJournals @ChauhanLab @Nirav_Dhanesha ahajournals.org/doi/full/10.…
ALT Graphic abstract in Patel and Kumskova et al.
Patrick Lyden retweeted
So when you try to slash the budgets of our research universities, our academic health centers, our sources of innovation, which ensure the greatness, the biosecurity, of the United States, that’s the head scratcher. Please reconsider, try to be more thoughtful, think deeper
Patrick Lyden retweeted
Honestly I think any American who cares about our future supports DOGE, Elon, that’s not the problem. It’s your failure to understand our nation is built on the strength of our great research universities institutions, which you benefited more than anyone I know, that’s the issue
Patrick Lyden retweeted
#ISC25 may be a wrap but you can catch up on all of the highlights from the meeting Chair and Vice Chair. spr.ly/6010I3b8k