LYmphocyte ACtivaTion and Signaling. Team leader Dr Thierry Walzer
Lyon, FRANCE
Joined May 2020
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LYACTS-CIRI retweeted
📢 SAVE THE DATE! RHUMATOPEDIES 2024 is coming
📅Wednesday 4th December 2024
📌 University of Lyon, 69007 LYON
👨⚕️ Lecture by Prof. Daniel Kastner, MD, PhD
📝 Registration: lnkd.in/emX8Pn8T
📰 Scientific Programme below
LYACTS-CIRI retweeted
6 novel monoallelic PTPN2 mutations in pediatric lupus and Evans syndrome that cause T cell hyperproliferation and high inflammatory cytokines @JExpMed
doi.org/10.1084/jem.20240980 @MACattackLab comment
doi.org/10.1084/jem.20232337
@AlexandreBelot @FRLab1 #Mathieu
LYACTS-CIRI retweeted
Very proud to share my first paper on my thesis project, a great collaborative effort between @CIRI_Lyon and @InstitutImagine, now published in @JExpMed. Check it out!
Jeanpierre, Cognard, @FRLab1, @AlexandreBelot, Mathieu @CIRI_Lyon et al. performed exome sequencing in pediatric systemic #lupus and Evans syndrome and identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. hubs.la/Q02HrHBb0
#autoimmunity
LYACTS-CIRI retweeted
Honored to have been part of this beautiful collaboration with @JEANPIERRMarie from @FRLab1 team in @InstitutImagine for my very first steps in the lab, thanks to @lyacts, @MaudTusseau @AlexandreBelot and Anne-Laure Mathieu ! ✨´
Jeanpierre, Cognard, @FRLab1, @AlexandreBelot, Mathieu @CIRI_Lyon et al. performed exome sequencing in pediatric systemic #lupus and Evans syndrome and identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. hubs.la/Q02HrHBb0
#autoimmunity
Thrilled to share our work on PTPN2 mutations in autoimmunity. Congratulations to all authors on this beautiful study! A great collaborative effort between @FRLab1 team at @InstitutImagine and @AlexandreBelot's team at @lyacts @CIRI_Lyon
@CgdJade @MaudTusseau @ALMathieu277161
Jeanpierre, Cognard, @FRLab1, @AlexandreBelot, Mathieu @CIRI_Lyon et al. performed exome sequencing in pediatric systemic #lupus and Evans syndrome and identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. hubs.la/Q02HrHBb0
#autoimmunity
LYACTS-CIRI retweeted
Excellent review on monogenic SLE:
link.springer.com/article/10…
LYACTS-CIRI retweeted
Mendelian causes of autoimmunity -> the #lupus phenotype! A fascinating (disease) syndrome #IEI, #RareDisease #Genetics with @MaudTusseau @SamiraPlassart @CgdJade @SarahBenezech @LilianeKhoryati @Seb_Viel @FRLab1 @lyacts, Still so much left to uncover.
LYACTS-CIRI retweeted
Ce 29 février, c'est le #RareDiseaseDay2024.
Au CIRI, les équipes I2BA (T. Henry) et LYACTS (T. Walzer) étudient des maladies rares auto-immunes et auto-inflammatoires.
Un grand merci aux cliniciens qui font avancer la recherche, et aux patient/es !
LYACTS-CIRI retweeted
❔Quel est le lien entre cancer et système immunitaire ?
Thierry Walzer, directeur de recherche @Inserm et chef de l'équipe @lyacts, l'explique dans l'émission #TêtesChercheuses, dont voici un extrait 👇
Retrouvez l'émission complète ici ➡ youtube.com/watch?v=B2N9133c…
Thierry Walzer porte un projet financé par la Fondation ARC qui vise à mieux comprendre les liens entre cancer et vieillissement du système immunitaire. Il est revenu pendant l'émission Têtes Chercheuses sur le rôle du système immunitaire.
L'émission : ow.ly/88sC50QzC6z
LYACTS-CIRI retweeted
🔬 🌐 Check out our comment on drug development in ultra-rare diseases in @TheLancet, spotlighting promising results of a new C5 inhibitor via SC route for CD55 deficiency. 🩺 #RareDiseases #MedicalBreakthrough"thelancet.com/journals/lance… ⤵️
LYACTS-CIRI retweeted
Fascinating paper on pre-covid possible MIS-C with implications for understanding pathogenesis. Congrats Alex Belot and team. Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children | NEJM nejm.org/doi/full/10.1056/NE…
LYACTS-CIRI retweeted
Fantastic research day at Rhumatopedies 2023, the 10th edition that welcome in Lyon many talented young researchers in the field of Pediatric Immunology/rheumatology & Incredible talk of our guest @BrodinPetter! Thanks for coming
LYACTS-CIRI retweeted
History of a success: exciting science, friendship and Cuisine Lyonnaise. @BrodinPetter #Rhumatopedies2023
LYACTS-CIRI retweeted
Sometimes groundbreaking research means demonstrating there nothing new but we missed it before! 'Old' Coronaviruses were triggering MIS-C in children before #SARSCoV2 👇👇👇
#pandemicpreparedness
A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens. Read the full correspondence: nej.md/49SwOTT
LYACTS-CIRI retweeted
Beautiful work from @AlexandreBelot and team on MIS-C assigned to the pre-COVID area, including TCR Vb21.3 expansion! xitter.cf/NEJM/status/1729996157…
A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens. Read the full correspondence: nej.md/49SwOTT
LYACTS-CIRI retweeted
MIS-C existed pre-COVID? See this report from @AlexandreBelot and colleagues. Time to re-think about Kawasaki disease and other post-infectious inflammatory conditions.
A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens. Read the full correspondence: nej.md/49SwOTT
LYACTS-CIRI retweeted
Correspondence: Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children nej.md/49SwOTT
#Pediatrics
LYACTS-CIRI retweeted
COVID-19 : le syndrome inflammatoire multi-systémique de l’enfant (PIMS) existait avant la pandémie teamhcl.chu-lyon.fr/covid-19… @CHUdeLyon @CIRI_Lyon (@UnivLyon1 @ENSdeLyon @InsermAuRA @CNRS_dr07)
Thrilled to share our paper in @NEJM on pre-COVID and SARS-CoV-2 negative MIS-C. This condition predates the pandemic but was incredibly rare and often misdiagnosed as Kawasaki Disease Shock Syndrome or Toxic Shock Syndrome without identified bacteria nej.md/49SwOTT 🧵
LYACTS-CIRI retweeted
A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens. Read the full correspondence: nej.md/49SwOTT
LYACTS-CIRI retweeted
Thrilled to share our paper in @NEJM on pre-COVID and SARS-CoV-2 negative MIS-C. This condition predates the pandemic but was incredibly rare and often misdiagnosed as Kawasaki Disease Shock Syndrome or Toxic Shock Syndrome without identified bacteria nej.md/49SwOTT 🧵