Entrepreneur, Investor & futurist advancing longevity, partial reprogramming & preventive medicine.
London
Joined July 2023
- Tweets379
- Following98
- Followers388
- Likes231
Fable 5.2 is cooking OMG!
findourearth.com/
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Google switched off my site in one hour.
$50,000+ of my own money. Solo founder, self-funded.
No warning. No explanation. No one to ask.
27 Oct, 22:00 UTC, 25 days after launch: ~360 Google impressions an hour, then under 50.
No manual action. Just a black box.
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What I've done since:
• Cut what Google can index by 96%
• Kept every page that ever earned a click
• Checked the tech: no errors, nothing blocked
• Search Console: no manual action, no message
Google: 9,345 impressions on 26 Oct, about 50 a day now.
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I'm not asking Google to reveal its algorithm. Fight spam, fine.
Just name the problem and I'll fix it. A black box that switches off self-funded projects without a word hurts the people who build them.
Lost Google on 27 Oct too? Reply with your launch date. @rustybrick
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LLM providers financial incentives will steer their models toward creating this dopamine hole; your output may skyrocket but output does rarely mean you are moving the right needle as far as your goals are concerned.
There’s 100% a kind of mania you can get into with coding agents, where it feels like you’re getting a lot done and working all the time but nothing is really happening.
I think it's often a form of avoidance of something else in life.
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My agents kept dying mid-run on "You've hit your session limit."
So I built Headroom. It's a Mac menu bar app: when one Claude account runs low, it moves Claude Code and Claude in Chrome to an account with room. Your agent keeps going on its next request.
While an agent drives Chrome, or you've picked an account yourself, it holds. Only running out moves it.
7 accounts. 188 switches in 4 weeks. Free and open source.
Tell your agent: install headroom from github
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And the total market currently addressed for GLP-1s is still in the single digit!
A weekly jab in the belly is generating more revenue than the entire AI industry.
Ozempic + Mounjaro: $71B in 2025.
OpenAI + Anthropic: $29B.
And they've barely started. ~2% of the 800 million eligible patients can currently access them.
h/t @DrSamuelBHume
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Your coding agent needs your API keys. It shouldn't see them.
I built akm so Claude Code and Codex use the keys in my Mac's Keychain by name. The values never enter the chat, the logs or the summaries.
My agents called it 19,000 times in five weeks.
Tell your agent: install akm from github
github.com/paperfoot/api-key…
brew install paperfoot/tap/akm · MIT · macOS
How do you give your agent API keys today?
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Your AI agent can use X now. Properly.
I built xmaster so my agent does my X admin, not me. It reads, posts, replies to any thread, and finds posts worth replying to in about 3 seconds. Free, through your own browser session.
Tell your agent: install xmaster cli from github
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Because I have 10+ subscriptions, because I like minimalistic and easy to visualise, please enjoy the most advanced LLM Switcher yet!
github.com/paperfoot/claude-…
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Just built an app to get my son to practice his times tables in a Duolingo-like gamified manner - initially built with Codex but then Opus 5.5 has improved many aspects of it.
There's a lot more that can be done, and I'm currently applying the same template on more advanced things he can start learning!
apps.apple.com/us/app/simply…
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Boris Djordjevic retweeted
Why do Great Danes live about 7 to 10 years while Chihuahuas live 16 years or more? Big dogs start aging at about the same age as small ones, but they age faster.
Today's @DogAgingProject paper in Science shows why: its the speed of DNA aging. In 894 pet dogs, the chemical tags that shift on DNA with age changed faster in big dogs, especially on jumping genes, bits of DNA that copy themselves around the genome and do damage once those tags wear off. Giant breeds lost those tags about 35% faster each year than small ones.
Breeding for size also left big dogs with high IGF-1, a growth hormone, and @loyalfordogs is going after it. Its shot lowers IGF-1 in big dogs toward small-dog levels, and the FDA agreed in 2023 that the data gives a reasonable expectation it works. A daily pill for senior dogs is also in a 1,300-dog trial.
So a big dog's short life may come from a faster aging clock, which a drug could try to slow. Neither is approved yet. If one is, it will be the first drug approved to extend lifespan in any species.
Why do small dogs live longer than large dog species, and what is the biologic basis of differences in lifespan and healthspan?
Epigenetics.
There's a lot in the methylation pattern of dogs to explain this @ScienceMagazine
science.org/doi/10.1126/scie…
Boris Djordjevic retweeted
Weekly retatrutide injections cut average weight by 25.0% at the highest dose, versus 3.9% with placebo, in adults with obesity but no diabetes. Those with knee arthritis also had less knee pain; those with sleep apnoea had fewer breathing interruptions.
agingresearch.news/p/MED-428…
🤖 Made with AI
ALT How much weight did people lose? Retatrutide reduced weight in adults with obesity. Highest retatrutide dose: 25.0%; Placebo: 3.9%. Average body weight loss over 80 weeks. Most common unwanted effects: digestive problems. 2339 adults with obesity, no diabetes · Randomised placebo-controlled trial. Peer reviewed.
22,000 new research papers a day. No one can keep up.
AgingResearch.News (@agingbrief) reads every new biomedical paper. Its journal club of AI agents judges on evidence, never fame, and keeps what matters for human aging.
Want to try it? DM me for a trial link.
