@lodder_bart

Neuroscience graduate student in the Sabatini Lab @harvard

Joined October 2020
  • Tweets40
  • Following55
  • Followers82
Neuron classes are distinguished by expression of many genes, including those for ion channel subunits. In cortex, PV+ neurons are the major expressors of Kcng4, which encodes for the K-channel "silent" subunit Kv6.4. @SanikaGanesh led this work showing that Kv6.4 regulates
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Bart Lodder retweeted
Bernardo Sabatini@blsabatiniMar 5
Not sure who is still out there but we're proud of this work led by @lodder_bart that (1) propose a new method to turn intensity sensors into lifetime sensors and (2) applies it to GCAMP8m to make an excellent lifetime Ca sensor. biorxiv.org/content/10.64898…

Rapid fluorescence lifetime sensor development of LifeCamp enables transient and baseline absolute...

Genetically encoded calcium sensors (GECIs) have been instrumental for studying neuronal activity and intracellular signaling. GECIs are typically fluorescence-intensity sensors that change brightn...

biorxiv.org
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Bart Lodder retweeted
Tarun Kamath@TVKamath2 Oct 2025
Excited to share some of my PhD work out today in @NeuroCellPress! We use our novel lifetime photometry system with the new dLight3.8 sensor to study hunger induced changes in exploration and risk assessment derive from AgRP modulation of dopamine signaling in tail of striatum.
Bernardo Sabatini@blsabatini2 Oct 2025
Our latest led by @TVKamath with important contributions by collaborators including Nao Uchida, Mitsuko Watabe-Uchida and @LinTianPhD Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum: Neuron cell.com/neuron/fulltext/S08…

Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum

Kamath et al. examine the neural mechanism by which hunger makes animals take more risks. They show that hunger neurons in the hypothalamus suppress threat and salience-related dopamine signals in...

cell.com
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Our latest led by @TVKamath with important contributions by collaborators including Nao Uchida, Mitsuko Watabe-Uchida and @LinTianPhD Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum: Neuron cell.com/neuron/fulltext/S08…

Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum

Kamath et al. examine the neural mechanism by which hunger makes animals take more risks. They show that hunger neurons in the hypothalamus suppress threat and salience-related dopamine signals in...

cell.com
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This is something we are very excited about. @lodder_bart led this development project collaborating with @LinTianPhD lab. The technology makes lifetime photometry easy and, with the new dopamine sensor, allows measurements of phasic and tonic DA in vivo biorxiv.org/content/10.1101/…

Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at...

The concentrations of extracellular and intracellular signaling molecules, such as dopamine and cAMP, change over both fast and slow timescales and impact downstream pathways in a cell-type specific...

biorxiv.org
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Bart Lodder retweeted
Rich Hakim@RichieHakim6 Apr 2022
Hello calcium imaging twitter, I have a thread for you. We made a self-supervised network that is great at ROI classification and tracking over sessions. If you do calcium imaging, it'll probably save you time. Help me improve it. Send your ROI masks to: [email protected]
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ViDA is excited to host @blsabatini for a keynote lecture on "Dopaminergic control of cellular state and action selection". Join the conversation! eventbrite.com/e/vida-2021-r…
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I am retweeting now because it links to the explanation of the findings in the just-published nature.com/articles/s41586-0… Thirteen months later, with lots of rewrites and a few new experiments, the conclusions are the same so please read below.
Bernardo Sabatini@blsabatini12 Nov 2019
Our latest work is now on available. Cell-type specific asynchronous modulation of PKA by dopamine during reward based learning biorxiv.org/content/10.1101/… This is collaborative work led by no-twitter MD/PhD student Suk Joon Lee with @yaochen20 @LinTianLab @SabatiniLab

Cell-type specific asynchronous modulation of PKA by dopamine during reward based learning

Canonical reinforcement learning models postulate that dopamine neurons encode reward prediction error (RPE) and provide a teaching signal to striatal spiny projection neurons (SPNs) in the form of...

biorxiv.org
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Bart Lodder retweeted
Jaeeon Lee@_JaeeonLee_25 Nov 2020
biorxiv.org/content/10.1101/… Extremely comprehensive work, with lots of parallel with our recent work. Just highlights how much fine topography there is in these small nuclei, and how we should try to target the relevant functional zone when doing behavior.

The mouse cortico-basal ganglia-thalamic network

The cortico-basal ganglia-thalamic loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimo...

biorxiv.org
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1/n We've posted a new study led by @sarahmelzer86 in collaboration with @LinTianLab. Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories biorxiv.org/content/10.1101/…

Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories

Disinhibitory neurons throughout the mammalian cortex are powerful enhancers of circuit excitability and plasticity. The differential expression of neuropeptide receptors in disinhibitory, inhibitory...

biorxiv.org
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Serotonin neurons modulate learning rate through uncertainty biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Are you or do you know an experience mouse colony manager who needs a job? It can be part time. Find our ad for HHMI funded position at HMS and apply.
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Very cool. Falls under the heading of the best ideas are often obvious in retrospect.
Ilya Kolb@i__kolb19 Oct 2020
Excited to share this cool new way of positioning many small probes in the brain from @HHMIJanelia ! To record information from the brain, neuroscientists want to place as many probes as possible on the head of a chronically implanted animal.
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Mesmerizing cortical activity - we saw this earlier today (i.e. we have no clue yet what it is - aside from "probably a seizure"): youtu.be/oXI5xI7tw6w
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Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain elifesciences.org/articles/5…
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Dopamine neuron synaptic connectivity defines physiological striatal domains biorxiv.org/cgi/content/shor… #biorxiv_neursci
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.@HHMIJanelia’s Optical Interest Group is currently partnering the @embl in a monthly seminar series. The presentations will be available to the public afterwards... 😀 Enjoy our first talks given by @PodgorskiLab & Anna Kreshuk 🎊 👉 janelia.org/content/optical-…
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This is a question that I frequently get from students. I start by labeling: Graduate school is as much about making discoveries in science, as it is a process of discovery about self. Discovery of your working patterns, interests, etc. I advice being purposeful in both. How? 1/
Paola Figueroa-Delgado@PaolaVFigueroa3 Oct 2020
What do you take under consideration when applying to a postdoctoral position? What do you look for? @OpenAcademics #ScienceTwitter #AcademicChatter #AcademicTwitter
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Basal ganglia functional topography is maintained across output nuclei and downstream targets, report @_JaeeonLee_ @blsabatini. This enables parallel modulation of behavioral action downstream of striatal regional activation. rdcu.be/b7OQz
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