@lcarpp

World citizen πŸŒŽβ”ƒ PhD ┃ Scientific writer in infectious diseasesπŸ¦ πŸ’‰πŸ§¬β”ƒ Living the dream: mingling w/biostatisticians, helping write+edit ms, grants...┃ She/her

 Montreal, Quebec
Joined February 2010
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9Media
Now online at @ScienceMagazine: 1st immune correlates paper emanating from the US Gov’t/COVID-19 Prevention Network (CoVPN) Biostatistics Team (& others!); 𝐃𝐫. 𝐏𝐞𝐭𝐞𝐫 𝐆𝐒π₯π›πžπ«π­ et al.’s analysis of the mRNA-1273 vaccine efficacy trial. science.org/doi/10.1126/scie… 🧡 (1/5)

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

SARS-CoV-2 binding and neutralizing antibodies correlate with the degree of vaccine efficacy and protection for the Moderna mRNA COVID-19 vaccine.

science.org
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✨New work from USG/CoVPN biostats team✨: Fong et al.'s immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial now out in @NatureMicrobiol rdcu.be/cZpHv
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First/senior authors Dr. Youyi Fong and Dr. Peter Gilbert; also with @biosbenk , @nshejazi, @mcaronebstat , @LarsvanderLaan3 , @aluedtke , @aprilkaurphd , @kathleen_neuzil and many others not on Twitter, + USG/CoVPN Team members @agartland , @ildiazm , + more
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Funding from @NIH @PreventCOVID_19; full statement in paper πŸ™
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New work by Gilbert and Huang et al. describing a serum nAb titer biomarker for Ab-mediated prevention of #HIV now published with @SpringerNature in @NatureMedicine: Read here rdcu.be/cT7PM #HelpEndHIV @HelpEndHIV
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See also hvtn.org/content/hvtn/en/new… via @fredhutch
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Also see this excellent blog post! healthcommunity.nature.com/p… #HelpEndHIV
New work from the US Gov’t/CoVPN Biostats Team (& others): Fong et al. immune correlates analysis of a single Ad26.COV2.S dose in the ENSEMBLE vaccine efficacy trial, on medRxiv: medrxiv.org/content/10.1101/… 🧡 1/7

Immune Correlates Analysis of a Single Ad26.COV2.S Dose in the ENSEMBLE COVID-19 Vaccine Efficacy...

Anti-spike IgG binding antibody, anti-receptor binding domain IgG antibody, and pseudovirus neutralizing antibody measurements four weeks post-vaccination were assessed as correlates of risk of...

medrxiv.org
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Another key finding: This comparison supports consistency in the ID50 nAb titer level needed for the same level of efficacy across mRNA and adenovirus-vectored vaccine platforms: potentially a transportable surrogate endpoint across vaccine platforms 🧡 6/7
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Funding from @NIH ππˆπ€πˆπƒ @PreventCOVID_19; full funding statement in manuscript. Thank you πŸ™#acwri #scientificwriting 🧡 7/7
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ICYMI..Philipp Dettmer (of the Kurzgesagt YouTube channel) has a book out on the immune system. Can't wait to see it! penguinrandomhouse.ca/books/…

Immune by Philipp Dettmer | Penguin Random House Canada

From the creator of the massive and engaging YouTube channel Kurzgesagt (In a Nutshell), a thorough and vibrantly illustrated journey into the human immune system--how it works and why it is both our...

penguinrandomhouse.ca
Now up @VirusesMDPI: π™π‘πšπ¨ 𝐞𝐭 𝐚π₯. present a new statistical learning strategy for tracking mutations in SARS-CoV-2 spike protein, w/viz representation of temporal dynamics mdpi.com/1415894 🧡(1/3)
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The approach is complementary to other genomic surveillance methods -- it monitors all Spike residues over time equally, independently of existing phylogenic classifications -- & incorporates πŸ“… temporal & 🌎geographic info🧡(2/3)
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With collaborators π“πžπ«π«π² π‹π²π›π«πšπ§π, 𝐏𝐞𝐭𝐞𝐫 𝐆𝐒π₯π›πžπ«π­, @joshua_schiffer, 𝐊𝐞𝐒𝐭𝐑 π‰πžπ«π¨π¦πž, & others not on Twitter. Funded by CoVPN #NIH @PreventCOVID_19 A privilege to be involved πŸ™ #acwri 🧡(3/3)
Our review of single-cell technologies applied to COVID-19 now out @NatureBiotech, w/standardized publicly available sc transcriptomic datasets (>3 mil cells!) + new viz portal for data exploration @_ytian_, @helenthehuman, MZ, @EvNewell1, @raphg rdcu.be/cDy4f 🧡1/3
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Hats off to anyone else trying to keep a COVID-19 related review current as ms traverses the peer review process -- always a challenge but seems especially intense now! #acwri 🧡2/3
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Really a privilege to be involved πŸ™; tremendous effort by all coauthors and especially @_ytian_. Thanks @hipcProject; full funding acknowledgments in paper. 🧡3/3
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