melanoma oncologist @mskcancercenter I clinical trials, cellular therapy & translational immunotherapy research | n.b.: personal account

New York, NY
Joined August 2010
This is a landmark moment in melanoma, cancer immunology, & IO drug development at large. Checkpoint inhibitors have allowed us to uncover & amplify the immune impact of cancer therapies we used for decades (e.g.,chemo, RT). Now, coupled with the powerful mRNA vaccine technology, finally unlocked the potential for personalized immunotherapy. Congrats to @Merck & @moderna_tx Grateful for our patients & research teams that allowed to participate in such a monumental accomplishment!
A promising step forward in melanoma treatment. ๐Ÿงฌ๐Ÿ’™ Merck and Moderna announced positive Phase 3 results from the INTerpath-001 trial, showing that an investigational, personalized mRNA-based therapy, intismeran autogene (V940), combined with KEYTRUDA, significantly improved recurrence-free survival and distant metastasis-free survival compared with KEYTRUDA alone in people with completely resected stage IIB-IV melanoma. This is the first positive Phase 3 readout for an individualized neoantigen therapy and marks an important milestone for personalized cancer treatment. The therapy is designed using the unique genetic โ€œfingerprintโ€ of each patientโ€™s tumor to help train the immune system to recognize and fight cancer cells. The study will continue to evaluate overall survival, and the full data will be presented at an upcoming medical meeting and shared with regulators. For people facing melanoma, every advance matters. Every breakthrough brings us closer to a future where more people can live longerโ€”and live melanoma-free. ๐Ÿ’™ merck.com/news/merck-and-modโ€ฆ #Melanoma #MelanomaResearch #CancerResearch #Immunotherapy #mRNA #ClinicalTrials
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Happy to share our collaboration led by @jsmithymd across 14 international centers on this study of ICI after progression on TIL in advanced #melanoma. โžก๏ธPost-TIL ICI activity was limited, with ORR 11% and median OS 8.8 months, underscoring the need for novel trials in this setting.
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An experimental vaccine from Moderna shows promise in keeping deadly skin cancer from returning for years, according to new clinical trial results. nbcnews.com/health/cancer/peโ€ฆ
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*fantastic* PFS data for darovasertib & crizotinib in HLA A 02:01 negative metastatic uveal melanoma โ€”huge step forward in an area with immense unmet need ๐Ÿ‘๐Ÿผ ๐Ÿ‘๐Ÿผ ๐Ÿ‘๐Ÿผ #ASCO26
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Today at #ASCO26: MSKโ€™s @jsmithymd shared his rapid oral abstract โ€œA phase 2 trial of IO102-IO103 and nivolumab-relatimab in previously untreated, unresectable #melanoma.โ€ โ€“ at Chicago, IL
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Join MSK melanoma medical oncologist Dr. @jsmithymd at #ASCO26 as he presents results from a phase 2 trial evaluating IO102-IO103 in combination with nivolumab-relatlimab in patients with previously untreated, unresectable melanoma. ๐Ÿ•’ Saturday, May 30 | 5:36 p.m. CDT Learn more: bit.ly/4u73WQz
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a translational tour de force covering the last 15 years in melanoma therapy by dr antoni ribas; immense progress but still lots of work to do ๐Ÿงฌ ๐Ÿงซ @MSKCancerCenter
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๐—ง๐—ต๐—ฒ ๐—ช๐—ผ๐—ฟ๐—น๐—ฑ ๐— ๐—ฒ๐—น๐—ฎ๐—ป๐—ผ๐—บ๐—ฎ ๐——๐—ฎ๐˜† ๐—š๐—น๐—ผ๐—ฏ๐—ฎ๐—น ๐—ฆ๐˜†๐—บ๐—ฝ๐—ผ๐˜€๐—ถ๐˜‚๐—บ continues with a series of expert-led sessions and presentations, featuring leading clinicians and researchers who highlight emerging therapies, share real-world clinical insights, and explore strategies to advance early detection and improve outcomes in melanoma care worldwide. ๐—๐—ฎ๐—บ๐—ฒ๐˜€ ๐—ฆ๐—บ๐—ถ๐˜๐—ต๐˜†(@jsmithymd) discussed emerging cell therapy platforms for advanced melanoma, highlighting innovative adoptive cell therapies and next-generation immune-based strategies that are expanding treatment possibilities for patients with refractory disease. ๐—ญ๐˜‚๐—น๐—ณ๐—ถ๐—พ๐˜‚๐—ฒ๐—ฟ ๐—ข๐˜๐˜๐˜† reviewed current approaches to first-line therapy of metastatic melanoma, focusing on treatment selection, immunotherapy combinations, and factors guiding personalized management in clinical practice. ๐—”๐˜…๐—ฒ๐—น ๐—›๐—ฎ๐˜‚๐˜€๐—ฐ๐—ต๐—ถ๐—น๐—ฑ shared perspectives on how melanoma is treated across Europe, outlining regional practices, evolving therapeutic standards, and the integration of novel systemic therapies into routine care. ๐—ญ๐—ฎ๐—ต๐—ฟ๐—ฎ ๐— ๐—ผ๐—ต๐—ฎ๐—บ๐—ฒ๐—ฑ ๐—”๐—ต๐—บ๐—ฒ๐—ฑ explored the challenges encountered when clinical guidelines meet real-world practice, emphasizing practical decision-making, resource considerations, and adapting evidence-based recommendations to diverse patient settings. More insights continue to emerge as the OncoDaily Global Symposium unfolds ๐ŸŒ ๐Ÿ”ด Live sessions available here: youtube.com/live/7TDHWCyn724โ€ฆ xitter.cf/i/broadcasts/1nxnRYQeAโ€ฆ #OncoDaily #Cancer #Oncology
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looking forward to a great day of discussion on solid tumor cell therapy at iwCART & sharing updates on PRAME-targeted TCR-T in advanced melanoma
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Among patients with immune checkpoint inhibitorโ€“related cutaneous adverse events, dupilumab therapy was associated with lower 5-year mortality compared to no dupilumab or systemic corticosteroids. ja.ma/4167rLa
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Ellen was diagnosed with a rare and hard to treat #ovariancancer. Everything changed when she enrolled in a clinical trial led by Dr. Rachel Grisham, based on a lab discovery years ago by @DSolit. Watch more #SavedbyScience stories on YouTube: bit.ly/3ZLODjv
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thatโ€™s a wrap on melanoma bridge! three days tackling the most pressing questions in the field with an inspiring roster of speakersโ€ฆ thank you @PAscierto & colleagues for organizing
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More than a year after receiving a type of immunotherapy called tumor-infiltrating lymphocyte (#TIL) therapy, Pattie is doing well and has almost no signs of metastatic #melanoma Learn more from @jsmithymd, a melanoma medical oncologist and cellular therapist at MSK and expert in #TILtherapy. bit.ly/3X9yBP0
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Published by โฆ@OncNewsCentralโฉ | I had a great conversation with Dr โฆ@jsmithymdโฉ & Dr Michael Postow on the latest in #Melanoma #Immunotherapy & #MolecularlyTargetedTherapy - Navigating Options โฆ@MoffittNewsโฉ โฆ@MSKCancerCenterโฉ oncologynewscentral.com/videโ€ฆ
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Scientists conducting medical research are facing an existential crisis: Layoffs and budget cuts pushed by President Trump that, they say, jeopardize finding a cure for cancer. Ted Koppel talks with cancer patients taking part in clinical trials for treatments and vaccines, whose own contributions to finding a cure are imperiled.
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Underway now in the #melanoma rapid oral abstract session at #ASCO25: Sarah E. Lochrin, MBBCh (@LochrinSarah) from @MSKCancerCenter shares interim results from the C-IT Neo trial on single-dose neoadjuvant ipilimumab + nivolumab in resectable melanoma, with CD8+ PET imaging. โžก๏ธ 59% major pathologic response after one dose โžก๏ธ Grade โ‰ฅ3 treatment-related AEs in just 9% โžก๏ธ CD8+ PET tracer uptake correlated with IHC, but not predictive of response #Immunotherapy #Neoadjuvant @ASCO #MoffittASCO25
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Congratulations to Kathryn Arbour @KCArbourMD and colleagues showing activity of BMS-986504 in MTAP-deleted solid tumors, including lung and pancreas cancer. @MSKCancerCenter
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