
Building real brain medicines from gene discovery | Neurogenetics, ASOs, chromatin, stem cells | @aluco_bio | Academic @Flinders | Opinions my own
Baltimore, MD šŗšø
Joined May 2015
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Jennifer Erwin retweeted
Many academics wonder why so little academic IP converts to successful Newcos. Itās because the classical patent-centered, transaction-heavy university TTO model is poorly matched to how value is actually created in modern venture-backed science.
Jennifer Erwin retweeted
Pet peeve: Obsessing over preclinical model data for a target with human (genetic or pharmacologic) evidence.
If the mouse or cell model gives a different phenotype than what's seen in humans, which are you going to believe?
Jennifer Erwin retweeted
A very impressive discovery of a new ECG marker for sudden cardiac death validated in 3 different cohorts and linked to benefit of defibrillator, an outgrowth of human research ingenuity and AI deep learning nature.com/articles/s41586-0ā¦
Jennifer Erwin retweeted
Academia already did what youāre proposing.
Universities are now run like businesses with professional administrators, branding strategies, risk management, consultants, and KPI dashboards. The result hasnāt been better research or teaching. Itās been the transformation of universities into brand-management and lifestyle companies, where prestige, expansion, and revenue extraction matter more than scholarship or education.
Research and teaching donāt reliably maximize short-term financial returns, so they get crowded out. What grows instead is administration because once an administrative class is established, its primary function becomes self-preservation and expansion, not mission fulfillment.
This is exactly what happens when a nonprofit adopts corporate logic without corporate accountability. You donāt get efficiency. You get mission drift and an institution optimized to look successful rather than to be successful.
Replying to @LocasaleLab
Academic life would improve if universities would dispose the 19th century decorum and be run like a business with clear roles: pure administration, pure research, pure teaching. Administration needs actual MBAs not theoretical physics PhDs
Jennifer Erwin retweeted
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development dlvr.it/TMdp9S
Jennifer Erwin retweeted
Courage is rarely priced in.
This is true of markets, public or private, elections, movements, or any organization that seeks to grow. When you see a courageous act, it can take many months for scale to follow and the narrative to catch up.
This is because analysts and experts have no idea how to price courage until the numbers or polls confirm it. But courage begets more courage in organizations. It energizes. It leads to more action from more people, which means more shots on goal, more chances at winning, more chances for growth, contracts, votes, etc.
Markets teach the principle but itās true everywhere: when you see a courageous act, the impact it will have on an outcome is often positive and rarely understood in the moment.
Never ignore courage.
šØ We're hiring! The Erwin Lab at Flinders University is looking for graduate students and postdocs passionate about neurogenetics, epigenetics & therapeutics.
Collaborate with biotech & launch a spinout.
š© [email protected]
š flinders.edu.au/people/jenniā¦
Jennifer Erwin retweeted
1/ Just out ināÆ@NatureMedicine : we show the opioid system modulates ketamineās effects in major depressive disorder, with naltrexone preātreatment reducing acute glutamatergic activity and acute antidepressant effects. nature.com/articles/s41591-0ā¦
Jennifer Erwin retweeted
š§ Our new study is out in Nature Communications!
DNMT1 regulates the migration of cortical interneurons, with implications for cortical layering and function ā and potentially neuropsychiatric conditions.
š doi.org/10.1038/s41467-025-6ā¦
Huge thanks to the amazing team/collaborators!
Jennifer Erwin retweeted
Are you passionate about harnessing innovative brain organoid technologies to explore the mysteries of neurodegenerative disorders? Would you like to pursue a Postdoc, MSc or PhD degree in Medical Neuroscience?Ā Join our exciting journey of discovery!
Jennifer Erwin retweeted
#PeeWeeAsHimself is this year's highest-rated TV show.
editorial.rottentomatoes.comā¦
Jennifer Erwin retweeted
LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis | Science Advances science.org/doi/10.1126/sciaā¦
Jennifer Erwin retweeted
Join us next Tuesday from 12:00-1:00 at UMB for another Baltimore Brain Series seminar! Awardees Dr. Bradley Keegan from NIDA and Bailey Spiegelberg from UMB will present their exciting work. Zoom link provided upon request! @UMMedNeuro
Jennifer Erwin retweeted
How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s41586-0ā¦. 1/12
Jennifer Erwin retweeted
Itās been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). Iām reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases.
I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share ā Iām trying to cast a wide net due to the rarity of this condition and how little is known.
People can contact me directly at my first name (as written in my profile) at octant.bio.
Jennifer Erwin retweeted
š¢ CUT&Tag version 3
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
biorxiv.org/content/10.1101/ā¦
Jennifer Erwin retweeted
A great resource: tandem repeat database in ā¦@AllofUsResearchā© with the expert input of ā¦@PacBioā© ā¦@MikeEberleā© ā¦@egor_dolzhenkoā© search.app/zkzCsN5Yx7Frwj85A
Jennifer Erwin retweeted
Check out our narrative review published in the new npj_Women's Heath "The biomechanics of the vagina: a complete review of incomplete data" written with the ultimate expert on vaginal biomechanics @devita_vt @UCSD_ObGyn @Nature_NPJ
"...By strengthening collaborations among experts in biomechanics and womenās health, [vaginal] mechanical attributes can guide the development and implementation of diagnostic and treatment strategies, improving womenās physical, mental, and emotional well-being throughout their lives.
nature.com/articles/s44294-0ā¦
Jennifer Erwin retweeted
1/ š§µ So excited to finally share our preprint! Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation (SV) on gene expression and DNA methylation- A new genomic resource for brain research! š§ āØbiorxiv.org/content/10.1101/ā¦
Jennifer Erwin retweeted
Delighted to see the completed Special Issue of Current Opinion in Genetics and Development on "Genome Architecture and Expressionā
It was a pleasure putting this together with Maya Capelson.
Thanks to all the authors that contributed articles
sciencedirect.com/special-isā¦
























