
Statistical geneticist @ Regeneron | PhD @broadinstitute & @harvardmed | tweets are my own
Joined April 2016
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Jack Kosmicki retweeted
A few readers have taken me to task for “missing the point of the film,” which is apparently that Elizabeth Holmes is unknowable and everything is ambiguous. Here’s my response: She went after Tyler Shultz and Erika Cheung with everything she had. I was threatened with litigation on a daily basis for months on end. It was a ruthless cover-up of a breathtaking fraud, and she was at the controls. Just a little context for those who have forgotten or didn’t follow the original story. By the way, I loved the film. #BestPicture, IMO.
A ton of people have asked me for my thoughts about “You Can See Everything,” the new Elizabeth Holmes documentary. Here they are: nytimes.com/2026/10/17/busin… via @NYTimes
Bryan Johnson must be working with the absolute dumbest/laziest set of geneticists if he can't figure out ANYTHING to do with his genome🤦♂️🧐
I can't find a way to use my genome.
I’m the most intense longevity athlete in the world and haven’t used my genome for a single thing.
Fully sequenced in 2012. Again this year, paying $7,902 for matched 30x long read + 100x short read.
Still, nothing.
What am I missing?
Just off the top of my head
- generate PGS for every trait / disease
- check for mendelian variants
- get HLA called (great for autoimmune dx)
- look EBV viral load @CalebLareau
- check your MT copy number @rahulg603 @VamsiMootha
Jack Kosmicki retweeted
I can't find a way to use my genome.
I’m the most intense longevity athlete in the world and haven’t used my genome for a single thing.
Fully sequenced in 2012. Again this year, paying $7,902 for matched 30x long read + 100x short read.
Still, nothing.
What am I missing?
Jack Kosmicki retweeted
Our single-nucleus immune multiome atlas is now out in @Nature! 🧬
10M PBMCs from 1,108 @FinnGen_FI donors recruited by @FRCBSresearch, profiled at @broadinstitute KCO with chromatin accessibility and gene expression in the same nuclei, to trace how disease variants act 🧵👇
Jack Kosmicki retweeted
Excited to introduce @ReactorfieldAI Cohort 1:
@merge - brain-computer interfaces with no implants, $250M seed led by OpenAI and Bain
@episteme - a new R&D institution, cofounded by Louis Andre and Sam Altman
@RetroBio_ - unicorn longevity startup, adding 10 healthy years to human life. In phase 1 trials
@NorthwellHealth - NY's largest healthcare system, with Chief Biotech Officer @itchdoctor
@StrandTx - programmable mRNA medicines out of MIT, lead cancer drug already in patients
@MayoClinic - turning leading clinical science into new ventures represented by @vera_mucaj
@xiliotx - publicly traded biotech making cancer therapies to activate inside tumors
@marathonfusion - producing the world's most valuable isotopes from compact fusion reactors
@KopraBio - viruses that turn cancer cells into factories for their own destruction
@radifymetals - hydrogen-plasma reactors that turn rare-earth oxides directly into metal
@FoundationManf - rapid domestic CNC machining for frontier hardware
@MassMagnetics - US-made high-performance magnets from recycled rare earths
@algabiosciences - turning cattle methane into calories, peer-reviewed cuts of up to 63%
@lumehealth - building a wearable that measures cortisol continuously from sweat
@liu_liu_lemon - smart materials for med tech and robotics, @Harvard PhD, Fulbright Fellow
AI transformed coding, science is next
@ReactorfieldAI makes scientists and deep tech startups AI-native
Built by me and @berkbuilds to accelerate science with frontier AI
Jack Kosmicki retweeted
Herasight: we use fake numbers to overstate our performance but at least the real numbers are also in the paper
Nucleus: hold my beer
AI is rapidly getting smarter.
Now, humanity can too.
Today, @nucleusgenomics is announcing Vitruvian, our newest set of genetic optimization models.
Vitruvian’s intelligence model can optimize embryo DNA for 14 IQ points — nearly a standard deviation.
The models were trained on 1,000,000+ people, validated across 40,000+ siblings, and used more than 7 million genetic markers.
In Superintelligence, Nick Bostrom proposed genetic optimization as a key way for humanity to keep pace with rapidly advancing AI.
Bostrom’s vision is no longer theoretical.
Genetic optimization, like AI, has followed a scaling law: as datasets have grown, so have model capabilities. This trend will continue.
Parents across the world now have the choice to substantially increase their child’s intelligence.
And the next generation can choose to do the same.
AI is no longer the only intelligence that will compound.
Humanity can now direct its own evolution.
Jack Kosmicki retweeted
the biggest lesson ive learned in the last 18 months is that most people are not interested in the truth but the elimination of uncertainty and just because they cant hold ambiguity about your work, doesnt mean you have to comply and collapse the uncertainty.. let us cook
New GWAS of Fibromyalgia identified 26 loci and found an HTT inframe indel (same gene as Huntington's disease [HD]). However, the Fibromyalgia variant isn't associated with HD, the HD CAG repeat isn't associated with Fibromyalgia, and they aren't in LD.
nature.com/articles/s41591-0…
Jack Kosmicki retweeted
AI transformed coding, science is next
@ReactorfieldAI makes scientists and deep tech startups AI-native
Built by me and @berkbuilds to accelerate science with frontier AI
Jack Kosmicki retweeted
In Germany, a talented 14-year-old earns his club money. In America, his parents pay the club $15,000 a year.
That single inversion explains why "we will not" is the most accurate line ever written about US soccer.
FIFA built a global system for this. Training compensation and solidarity payments send a cut of every transfer fee back to the clubs that developed the player, from age 12 onward. Develop one future pro and your academy gets paid for a decade. Barcelona's La Masia, Ajax, every Bundesliga academy runs on this logic. The kid is the asset.
US Soccer refuses to enforce those rules. When Seattle's Crossfire Premier claimed its $60,000 share of DeAndre Yedlin's transfer to Tottenham, it got nothing. Claims on the Dempsey and Bradley transfers died partly because the federation couldn't even produce the youth training records.
So American clubs earn zero dollars when a kid turns pro. They earn when a kid enrolls. Which makes the parent the customer, and the product is whatever keeps the parent writing checks: travel tournaments, hotel weekends, $500 showcase events, private training at $100 an hour. Elite pathways run $8,000 to $20,000 a year. A comparable academy spot in Italy costs about 120 euros.
Follow the incentive one level deeper and it gets darker. A club dependent on fees can't cut its weakest paying players, so rosters optimize for retention over development. The scouting pool shrinks to families who can afford the cliff, which appears around age 11, exactly when development matters most. The country runs a talent filter sorted by household income instead of ability.
Every four years someone proposes fixing this. The proposal always requires the people profiting from the $15,000 model to vote themselves out of business.
They will not.
Jack Kosmicki retweeted
Very excited to share a powerful new method, graphREML, for common-variant heritability partitioning and enrichment from GWAS sumstats, now published in @NatureGenet
Led by 1st author Hui Li, co-supervised with @XihongLin
After 4 years, it's rather nice to finally present our work on genetic's model trait, height, in >1.4M WES/WGS samples led by @doc_locke, @Mar_ferreira17, & @gabecasis where we found 207 genes [amongst many other results].
A thread of findings below⬇️
medrxiv.org/content/10.64898…
Inspired by one of my favorite papers by @HHeyne & @dalygene on recessive associations in FinnGen, I sadly only found 1 recessive association missed by the additive test - CFTR's delta508 mutation (recessive P=5e-10; additive P=0.14).
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