@ipekresearch

Institute for Cardiovascular Prevention, Munich University Hospital @LMU_Uniklinikum @LMU_Muenchen Institute Director Christian Weber @dfg_public @dzhk_germany

 Munich, Bavaria
ipek-research.com
Joined May 2019
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  • Followers445
62Media
📢TOMORROW ‼️
CRC1123: Mechanisms of Atherosclerosis@CRC1123_AtheroApr 29
📢Looking forward to our next CRC 1123 Keynote Lecture 🧑‍🏫by Clément Cochain next week on TREM2+ macrophages in atherosclerosis and MI ipek-research.com/news-repor… @dfg_public @SteffensLab @ipekresearch
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📢Looking forward to our next CRC 1123 Keynote Lecture 🧑‍🏫by Clément Cochain next week on TREM2+ macrophages in atherosclerosis and MI ipek-research.com/news-repor… @dfg_public @SteffensLab @ipekresearch
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The #MIAS2025 Symposium in Munich brought together global experts to advance research on #atherosclerosis, #immunity & #metabolism. 🌟Editorial perspective by @NatureCVR @Vesna_Tod and young scientists awards 🎖️Simon Ebert & Robby Zachariah-Tom #CardiovascularResearch ❤️‍🩹
CRC1123: Mechanisms of Atherosclerosis@CRC1123_Athero7 Jun 2025
📢Registration is open for the International 🗺️#Atherosclerosis Symposium in Munich 🥨, Oct 21–22, 2025! 🧬 Hosted by @dfg_public CRC 1123. Join top experts🧑‍🔬👩‍🔬 for talks, posters & networking! Abstract deadline: July 31. ➡️Details & sign-up: mias2025.de #Science
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📢Looking forward to our next CRC 1123 🎓Graduate School Lecture by Florian Gärtner next week @LMU_Muenchen on Mechanisms of 3D Cell Migration ipek-research.com/scrivito/n… @dfg_public @SteffensLab
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In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. Learn more in @SciSignal: scim.ag/4kTxFZz
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A preclinical study uncovers a metabolic pathway that offers a target in neuropathic pain, scientists discover how chemokines can support red blood cell production in mice, and more this week in #ScienceSignaling. scim.ag/3HEv8no
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Not all chemokine signaling is about cell migration! In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation. 🔗 science.org/doi/10.1126/scis… #chemokine #CXCR4

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and...

CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

science.org
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📢Registration is open for the International 🗺️#Atherosclerosis Symposium in Munich 🥨, Oct 21–22, 2025! 🧬 Hosted by @dfg_public CRC 1123. Join top experts🧑‍🔬👩‍🔬 for talks, posters & networking! Abstract deadline: July 31. ➡️Details & sign-up: mias2025.de #Science
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#TODAY 🗓️5pm CRC1123 Graduate 🎓Lecture 🧑‍🏫by Leo Nicolai on #Platelets in acute and chronic #inflammation ➡️ ipek-research.com/news-repor… @dfg_public @SteffensLab
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📢Looking forward to our next Graduate CRC1123 👩‍🏫 Lecture Series next week by🗣️Zhifen Chen @TU_Muenchen on Risk 🚨and Resilience Mechanisms for Coronary Artery Disease 🫀🩺 in #Obesity 📏⚖️ ipek-research.com/news-repor… @dfg_public
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Great emotional week with conferences, defended thesis and meeting old colleagues. Congratulate Dr. @GeorgeShakir on his new achievement. linkedin.com/posts/raquel-gu…
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📢#TODAY Looking forward to our CRC/IRTG 1123 🧑‍🏫Seminar Series @dfg_public @LMU_Muenchen 🗣️ Slava Epelman @EpelmanLab @UHN_Research @PMunkCardiacCtr @trogersresearch @UofT 📌 Enhancing engineered 🧫heart tissues with macrophages ipek-research.com/news-repor…
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📢Looking forward to our next joint CRC/IRTG 1123 🧑‍🏫Seminar Series this week 🗓️@dfg_public @LMU_Muenchen 🗣️ Slava Epelman @EpelmanLab @UHN_Research @PMunkCardiacCtr @trogersresearch @UofT 📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages ipek-research.com/news-repor…
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📢Looking forward to our next joint CRC/IRTG 1123 🧑‍🏫Seminar Series next week 🗓️@dfg_public @LMU_Uniklinikum 🗣️ Slava Epelman @EpelmanLab @UHN_Research @PMunkCardiacCtr @trogersresearch @UofT 📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages ipek-research.com/news-repor…
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Played a minor part but that’s us @CRC1123_Athero
Daniel J Drucker@DanielJDrucker8 Mar 2025
MIF-2 positioned as an atypical chemokine linking vascular inflammation to metabolic dysfunction in atherosclerosis through CXCR4 @naturecomms nature.com/articles/s41467-0…

An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

Nature Communications - Fatty liver disease exacerbates atherosclerosis, but the underlying mechanisms remain unclear. Here, the authors show that D-dopachrome tautomerase (D-DT/MIF-2) acts as an...

nature.com
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Congratulations to Harini Balasubramanian on her Master’s degree - well done! I am proud of you and the work you've done in the lab👩‍🔬 Looking forward to exciting future work together! @ipekresearch
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CXCL12-CXCR4 axis drives CD8+ T cell plaque infiltration and may play a role in human atherosclerosis @_LauraParma @DucheneJohan @ipekresearch @LarsMaeg @mariedepuydt ahajournals.org/doi/full/10.…
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Very excited to share our latest discoveries revealing the crucial role of the merhyltransferase Ezh2 in T cells during #atherosclerosis 🧬 @AtzlerLab @LutgensEsther @ipekresearch @CRC1123_Athero @dzhk_germany @LMU_Muenchen Now online @CircAHA ahajournals.org/doi/full/10.…

Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis | Circulation

BACKGROUND: The activation and polarization of T cells play a crucial role in atherosclerosis and dictate athero-inflammation. The epigenetic enzyme EZH2 (enhancer of zeste homolog 2) mediates the...

ahajournals.org
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T cells, especially CD8, are recognized to be the main hematopoietic cells in human atherosclerotic plaques. How are they recruited? We developed a 3D tissue culture model and found that intraplaque ACKR1+ vessels secrete CXCL12 and recruits CD8 cells. ahajournals.org/doi/10.1161/…

CXCL12 Derived From ACKR1+ Intraplaque Neovessels Mediates CD8+ T Cell Recruitment in Human...

ahajournals.org
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Why are ACKR1+ intraplaque neovessels key in atherosclerosis? These venular vessels express CXCL12 that attracts CD8+ T cells via CXCR4 in the plaque This may unlock new cardiovascular therapy #Atherosclerosis #Chemokines Read our study here 👇👇👇 ahajournals.org/doi/10.1161/…
Representative images showing intraplaque ACKR1+ neovessels (ACKR2, blue; CD31, green) producing CXCL12 (red) in human atherosclerotic plaque.

ALT Representative images showing intraplaque ACKR1+ neovessels (ACKR2, blue; CD31, green) producing CXCL12 (red) in human atherosclerotic plaque.

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