Lactobacillus murinus delivers small RNAs to activate macrophage defenses and protect against drug-resistant K. pneumoniae infection.
onlinelibrary.wiley.com/doi/…
Latest research paper: Domesticated bacterial origin genes regulate homeostasis of the insect gut microbiome and empower adaptation
onlinelibrary.wiley.com/doi/…
Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae
🔎Ampicillin promotes pathogen persistence and evolution, while short-chain fatty acids help restrict its expansion. onlinelibrary.wiley.com/doi/…
Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy
💡 Choroidal hypertension drives pathological angiogenesis through the EDN1/EDNRA axis, revealing a potential therapeutic target for pachychoroid PCV. onlinelibrary.wiley.com/doi/…
Gut virome orchestrates nitrogen partitioning between the host and microbiome 🦠
💡 Protein restriction reshapes phage–bacteria interactions, reducing bacterial lysis and microbial protein release and thereby limiting nitrogen availability to the host.
onlinelibrary.wiley.com/doi/…
Review article: Deciphering transcriptome complexity via long-read sequencing
🔎Long-read sequencing resolves full-length transcripts and linked regulatory features, enabling isoform-resolved transcriptome characterization. onlinelibrary.wiley.com/doi/…
🧐Infection mechanisms of Rhizoctonia cerealis in wheat
The RcPL3–TaHDA9–TaRHC1A–TaRBOH3 cascade reveals a key mechanism of fungal pathogenicity and identifies HY-19741 as a potential wheat disease control agent.
onlinelibrary.wiley.com/doi/…
Decoding ferroptosis via integrated multi-omics analyses in rice blast 🌾
💡 Ferroptosis links iron homeostasis, ROS/redox imbalance, and lipid peroxidation to both rice immunity and Magnaporthe oryzae infection.
onlinelibrary.wiley.com/doi/…
iMeta retweeted
🔥The iMeta Conference 2026 has come to a successful close!!!🥳
Researchers from diverse fields gathered to discuss the latest advances in information science, meta-omics, and life sciences, sparking new ideas and fostering interdisciplinary collaboration.
#iMeta #LifeScience
🔥The iMeta Conference 2026 has come to a successful close!!!🥳
Researchers from diverse fields gathered to discuss the latest advances in information science, meta-omics, and life sciences, sparking new ideas and fostering interdisciplinary collaboration.
#iMeta #LifeScience
Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia
💡 Severe disease features S100A8/A9/A12-high inflammatory monocytes, impaired antigen presentation, and disrupted adaptive immune coordination. onlinelibrary.wiley.com/doi/…
Decoding sequence recognition code of nucleic acid-binding proteins of human-infecting DNA viruses 🦠
💡 103 viral NBPs reveal diverse DNA-binding motifs, conserved CCACC recognition, and potential viral NBP–mitochondria interactions.
onlinelibrary.wiley.com/doi/…
Metal-dependent regulated cell death: Molecular architecture and translational frontiers
💡 This review explores emerging metal-dependent cell death pathways and their therapeutic potential in cancer, tissue degeneration, and immunotherapy. onlinelibrary.wiley.com/doi/…
Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives 🤖
💡 Compares spatial omics platforms and algorithms, highlights key challenges, and explores AI-driven advances in spatial biology.
onlinelibrary.wiley.com/doi/…
Wekemo Bioincloud 2026: An AI‐enabled platform for standardized multi‐omics data analyses
onlinelibrary.wiley.com/doi/…
Soil-derived, gut-dominant generalist bacteria shape the fitness of folivorous larvae 🐛
💡 Soil-derived Ralstonia insidiosa and Delftia sp. widely colonize folivorous larvae, with opposing effects on larval growth.
onlinelibrary.wiley.com/doi/…
Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects
onlinelibrary.wiley.com/doi/…
👁️Spatial multi-omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche
💡 Trem2⁺ microglia and the TREM2–SPTLC2 axis are linked to sphingolipid remodeling and retinal ganglion cell degeneration.
onlinelibrary.wiley.com/doi/…
Multi-omics-driven precision medicine (MODPM) is understood as a multiscale decision architecture that links molecular heterogeneity, tissue context, and patient-level trajectories.
onlinelibrary.wiley.com/doi/…
🧐The Human Biomarker Navigator integrates biomarkers across nine physiological systems, organs, and diseases into a comprehensive navigation framework.
#Biomarkers #SystemsBiology
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