AI 4D Cell Biology! Watch mitochondria reveal their hidden phenotypes! We built MitoSpace, a self-supervised model trained without labels on terabytes of 4D lattice light-sheet movies of single cells. It learns representations that outperform predefined features, predict membrane potential from 4D form alone (R²=0.91), and generalize zero-shot to unseen drugs and human lung organoids. 🎉 Now published in @CellCellPress! With @DrvAgwl @ZacharyWang379 @ecarkfeld @andremodolo4 @Parth_LFC @hhako2     @GCMcMahon 📄 Paper: cell.com/cell/fulltext/S0092… 🔬 Explorer: mitospace.ai 💻 Code: github.com/schoeneberglab/Mi… 🤗 Model: huggingface.co/schoenebergla… #AI4DCellBiology #cellbiology #microscopy #LLSM #latticelightsheet #mitochondria #deeplearning #phenomics

Watch a virtual cell come to life! We built whole-cell, particle-based digital twins of living cells, reconstructed directly from 4D lattice light-sheet microscopy. 🎉 Now published in @CellCellPress! With @ecarkfeld @ZacharyWang379 @hhako2 📄 Paper: cell.com/cell/fulltext/S0092… 💻 Code: github.com/schoeneberglab/re… #cellbiology #microscopy #LLSM #latticelightsheet #simulation #mitochondria #microtubules

Super excited to introduce MitoSpace: The first mitochondrial phenotypic atlas created using self-supervised deep learning! @Parth_LFC @ZacharyWang379 @AroraMehul1 @hhako2 biorxiv.org/content/10.1101/… #MachineLearning #deeplearning #ai #drugdiscovery #microscopy #mitochondria

Like to grow brains? Our lab is hiring a #postdoc in #4D #mitochondria dynamics in Brain #organoids 🧠🔬🎉! Please spread the word and apply here: forms.gle/2tBGXvt4TNySwToF9

Very excited to introduce MitoTNT: Mitochondrial Temporal Network Tracking for 4D live-cell fluorescence microscopy data. Excellent work @ZacharyWang379, @Parth_LFC, @hhako2 et al! biorxiv.org/cgi/content/shor… #biorxiv_cellbio #biorxiv #latticelightsheet #llsm #lls #microscopy