AI 4D Cell Biology! Watch mitochondria reveal their hidden phenotypes! We built MitoSpace, a self-supervised model trained without labels on terabytes of 4D lattice light-sheet movies of single cells. It learns representations that outperform predefined features, predict membrane potential from 4D form alone (R²=0.91), and generalize zero-shot to unseen drugs and human lung organoids. 🎉 Now published in @CellCellPress! With @DrvAgwl @ZacharyWang379 @ecarkfeld @andremodolo4 @Parth_LFC @hhako2     @GCMcMahon 📄 Paper: cell.com/cell/fulltext/S0092… 🔬 Explorer: mitospace.ai 💻 Code: github.com/schoeneberglab/Mi… 🤗 Model: huggingface.co/schoenebergla… #AI4DCellBiology #cellbiology #microscopy #LLSM #latticelightsheet #mitochondria #deeplearning #phenomics

Watch a virtual cell come to life! We built whole-cell, particle-based digital twins of living cells, reconstructed directly from 4D lattice light-sheet microscopy. 🎉 Now published in @CellCellPress! With @ecarkfeld @ZacharyWang379 @hhako2 📄 Paper: cell.com/cell/fulltext/S0092… 💻 Code: github.com/schoeneberglab/re… #cellbiology #microscopy #LLSM #latticelightsheet #simulation #mitochondria #microtubules

4D mitochondrial network assumes distinct and predictive phenotypes through human lung and intestinal epithelial development! @GCMcMahon et al: #latticelightsheet #microscopy of #mitochondria in #organoids from #stemcells to study #devbio - #4dcellbio. 📄:biorxiv.org/content/10.1101/…

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data! @ecarkfeld @ZacharyWang379 @hhako2 📄: biorxiv.org/content/10.1101/… 💻: github.com/schoeneberglab/re… #simulation #latticelightsheet #llsm #microscopy #cellbiology #mitochondria #microtubules