Clinical academic critical care medicine. Antibiotic stewardship in critically ill patients. Clinical deputy director Newcastle CTU. @SHORTERtrial @RiscSepsis
Newcastle University
Joined June 2010
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Tom Hellyer retweeted
CoReCCT trials are now open to recruitment
@DarkNatter @gazkitch @ICS_updates @WarwickCTU @KeithCouper @EPPiC_Warwick @Luigi_ICM @dfmcauley @DanJHadfield @ProfLouiseR @perkins_gd @WUTHresearch
Tom Hellyer retweeted
We're hiring! The NIHR-funded @SHORTERtrial seeks a Senior Research Fellow for the Process Evaluation. A great opportunity for qualitative/mixed-methods researchers to step into a senior role and develop leadership skills @EdinburghNapier
Apply now ⬇️
jobs.ac.uk/job/DLA526/senior…
Tom Hellyer retweeted
#CCRdownunder24 congress just started
1st study ADAPT-Sepsis published in @JAMA_current
Procalcitonin guided protocol ⬇️ antibiotic treatment duration by 1day (significant)
but 28-day mortality non-sign⬆️by 7% (relative risk): from 19.4 to 20.9%
jamanetwork.com/journals/jam…
Tom Hellyer retweeted
Published in JAMA with #CCRdownunder:
In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.
@CritCareReviews
ja.ma/41t10TE
Tom Hellyer retweeted
7d is not a country mile away from standard care in the UK. Recognising microbiological cure is hard. Antibiotics are not without harm. Try @SHORTERtrial @hellyerthomas
Original Article: Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (BALANCE) nej.md/3Z5bTJD
#CCCF2024 | @CCCForum
ALT Forest plot of the primary outcome according to analysis.
ALT Forest plot of the primary outcome according to subgroup.
Tom Hellyer retweeted
Presented at #CCCF2024:
In the BALANCE randomized clinical trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results: nej.md/3Z5bTJD
ALT A forest plot of the primary outcome according to analysis.
Tom Hellyer retweeted
UK critical care could offer @SHORTERtrial to patients. @hellyerthomas
Tom Hellyer retweeted
This is what I gleaned the working group recognised and will seek to address (1) the infeasibility of training in academia and two medical specialities (2) academia now linked to pay penalties through slower progression and diminished merit awards….
Tom Hellyer retweeted
More posters today from trial managers Gillian Watson and @AGrSwain Come and find out more about recruitment during COVID-19 and lessons in running dental trial @enhanced_trial #ICTMC2024
7 days in the week. 5 digits on your hand. So naturally antibiotic courses are multiples of 7 or 5 🤔.
@SHORTERtrial large @NIHRresearch funded trial investigating short (5 day) course of antibiotics vs SoC in sepsis. Challenging the 'week's course' dogma.
Challenging dogma if evidence non‑existent, weak, outdated part II
💊give a week’s course of ABT
🍬standardized management for DKA
🫀icarbonate improves contractility in severe acidosis
⚗️hypophosphatemia needs correction
🔓rdcu.be/dVaRu
Part I
🔓rdcu.be/dVaUx
Tom Hellyer retweeted
New data released today in @TheLancet shows that without urgent action, antimicrobial resistance could kill 39 million people by 2050.
Deaths and inequities from the global antibiotic emergency are increasing and now is the time to take urgent action.
thelancet.com/journals/lance…
Tom Hellyer retweeted
💥💥💥MAIN RESULTS💥💥💥
The PEACH team are delighted to finally share the main results of this study!
@CarrolEnitan @j_sandoe @emma_tj1 @Dr_JoanneEuden @LBrookesHowell @DetelinaGrozeva @CTRCardiffUni @UniversityLeeds and many others.
academic.oup.com/jac/advance…
Tom Hellyer retweeted
NHIP Academy was delighted to support eight exceptional researchers throughout their application process to be successfully awarded the new Senior Clinical and Practitioner Research Award (SCPRA) from the @NIHRresearch (NIHR).
Read the full story here: newcastlehealthinnovation.or…
Tom Hellyer retweeted
There is a crisis in clinical academia in the UK. We talk of the need to expand medical schools, embed research into the NHS to improve care, & the importance of a vibrant life sciences sector for the economy of the UK, & yet we seem unable to tackle the underlying issues 1/9
ALT Quote from the Academy of Medical Sciences "Transforming health through innovation: Integrating the NHS and academia" report from January 2020.
ALT Quote from the Academy of Medical Sciences "Transforming health through innovation: Integrating the NHS and academia" report from January 2020.
Amazing effort by the @SHORTERtrial sites and by the @NclCTU team to get off to such a good start. Keep on going!
19 sites open and 168 patients have had the opportunity to participate in research! Wow! Incredible work by all the @SHORTERtrial sites. Keep up the good work. More sites to open soon. 🎯👏👏👏
@NIHRresearch @NclCTU @UniofNewcastle @hellyerthomas
Tom Hellyer retweeted
19 sites open and 168 patients have had the opportunity to participate in research! Wow! Incredible work by all the @SHORTERtrial sites. Keep up the good work. More sites to open soon. 🎯👏👏👏
@NIHRresearch @NclCTU @UniofNewcastle @hellyerthomas
Tom Hellyer retweeted
❌ We NEVER want to see a sign like this ever again. ❌
The next government has the power to make that happen.
They can end the need for food banks.
ALT A sign with two arrows on. One arrow points left and is labelled 'food bank'. The second arrow points right and is labelled 'election'.
Tom Hellyer retweeted
#A2Btrial results presentation is now live!
Dexmedetomidine vs Clonidine vs Propofol for ICU sedation
criticalcarereviews.com
#CCR24
@Ed_TimWalsh Chris Weir & Ranjit Lall
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Tom Hellyer retweeted
Delighted to review #BLINGIII examining continuous v intermittent infusion in critically ill patients with sepsis, at #CCR24. While this one sentence JAMA summary is technically correct, the full data and discussion at #CCR24 provides a different perspective. Here is why..1/
BLING III: In critically ill patients with sepsis, continuous vs intermittent β-lactam antibiotic infusions did not significantly reduce 90-day mortality.
ja.ma/3VEouCa
#CCR24
