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🔥🔥IDSA AMR Guidance 2026🔥🔥
🔺Notable Updates from the 2024 IDSA AMR Guidance Document
IDSA 2026 Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections
🔺ESBL, AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia
Including updates in antimicrobial selection, dosing strategies, and management approaches.
🔺Meropenem dosing update: individualized dosing approach (1–2 g IV q8h) with higher doses considered in selected clinical scenarios.
Info inspired / credit to @RabeaAgeeli , #IDXposts
idsociety.org/practice-guide…
🤖 Made with AI
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How long should anticoagulants be withheld before elective surgery?
◻️Apixaban: 1 day (low/moderate bleeding risk), 2 days (high risk)
◻️Rivaroxaban: 1 day (low/moderate), 2 days (high)
◻️Edoxaban: 1 day (low/moderate), 2 days (high)
◻️Dabigatran: 1-4 days depending on bleeding risk & renal function
◻️ Fondaparinux: 36-42 hours
◻️ LMWH: 12 h (prophylactic), 24 h (therapeutic)
◻️ UFH: IV 4-6 h; SC 12–24 h
◻️ Warfarin: Stop 5 days before surgery; confirm INR before the procedure.
Adjust timing for renal impairment, neuraxial anesthesia, and individual patient risk. Bridging is reserved for selected high-thrombotic-risk patients.
Reference: 2024 AHA/ACC Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery, Table 13.
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#BREAKING🚨: Today in Utqiagvik, the sun rose above the horizon at 2:57 AM after 65 days and won’t set again for 84 straight days or until August 2nd!
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This woman just made ultramarathon history in 56-hour, 250-mile run in Arizona.
Rachel Entrekin won the Cocodona 250 outright in a 56-hour, 250+mile effort, beating the entire men’s field, setting a new course record, and marking a landmark moment in ultrarunning history.
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CBC made simple 🩸
Start with hemoglobin, then follow the pattern—RBC indices, WBCs, and platelets.
Don’t chase one number.
Think clinically.
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🧠 Baroreceptors & Chemoreceptors – High-Yield Physiology
⸻
The medulla (NTS) integrates cardiovascular signals from baroreceptors and chemoreceptors to maintain BP and perfusion.
⸻
🔍 Baroreceptors (Pressure Sensors)
• Carotid sinus → CN IX
• Aortic arch → CN X
• Respond to BP changes (stretch)
↓ BP → ↓ firing → ↑ sympathetic + ↓ parasympathetic →
→ ↑ HR, ↑ contractility, vasoconstriction → ↑ BP
⸻
🫁 Chemoreceptors (Gas Sensors)
• Peripheral (carotid & aortic bodies):
Respond to ↑ CO₂, ↓ pH, ↓ O₂ (<60 mmHg)
• Central (brainstem):
Respond to CO₂ & pH only (NOT O₂)
Less sensitive in chronic hypercapnia (COPD)
⸻
⚠️ Clinical Correlations
• Carotid sinus hypersensitivity:
Trigger (shaving/tight collar) → ↓ HR → syncope
• Cushing Reflex (↑ ICP):
→ Hypertension + bradycardia + respiratory depression
⚡ Late sign of impending herniation
⸻
💡 Clinical Pearl
Baroreceptors = short-term BP control
Chemoreceptors = oxygen & CO₂ sensing
⸻
📚 Stay tuned for our new Physiology Step 1 USMLE book – clear, visual, and high-yield
🌐 mediconotes.com
#USMLE #Physiology #Cardiology #MedSchool #MedicalEducation
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A Mayo Clinic-developed artificial intelligence (AI) model can help specialists detect pancreatic cancer on routine abdominal CT scans up to three years before clinical diagnosis. It identifies subtle signs of disease before tumors are visible, when curative treatment may still be possible. The findings, published in Gut, mark a milestone in Mayo Clinic's multiyear research effort to enable earlier detection of one of the deadliest cancers.
Learn more: mayocl.in/4eippBP
