@gwihelm
 Paris, France
Joined December 2019
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A new preprint from the always great @BeatoLab , with some contribution from our side! biorxiv.org/content/10.1101/…

Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneu...

In neurological conditions affecting the brain, early-stage neural circuit adaption is key for long-term preservation of normal behaviour. We tested if motoneurons and respective microcircuits also...

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Another preprint from @RoselliLab , from the great collaboration with @gwihelm and the Zytnicki lab: biorxiv.org/content/10.1101/…

Non-canonical adrenergic neuromodulation of motoneuron intrinsic excitability through β-receptors...

Altered neuronal excitability and synaptic inputs to motoneurons are part of the pathophysiology of Amyotrophic Lateral Sclerosis. The cAMP/PKA pathway regulates both of them but therapeutic interv...

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How is motoneuron output modulated? Does the modulation changes in ALS? How are small-molecules in clinical practice affecting motoneurons? Find out in our latest preprint: biorxiv.org/content/10.1101/…

Non-canonical adrenergic neuromodulation of motoneuron intrinsic excitability through β-receptors...

Altered neuronal excitability and synaptic inputs to motoneurons are part of the pathophysiology of Amyotrophic Lateral Sclerosis. The cAMP/PKA pathway regulates both of them but therapeutic interv...

biorxiv.org
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we congratulate @gwihelm for being awarded the poster prize at the @ENCALS meeting in Barcelona!
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I am tremendously honored to receive the poster award at #ENCALS in Barcelona. I particularly want to thank my amazing collaborators from @RoselliLab and Zytnicki lab for their huge efforts!
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Replying to @gwihelm
@gwihelm, @bilchak_j and @mpcotelab (@mmscrc) show how bumetanide changes postsynaptic inhibition after chronic SCI and step-training! 📜buff.ly/3mBhxCS
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link.springer.com/book/10.10…

Vertebrate Motoneurons

link.springer.com
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Spinal cord injury alters spinal Shox2 interneurons by enhancing excitatory synaptic input and serotonergic modulation while maintaining intrinsic properties in mouse dlvr.it/S008jw
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[my French boyfriend, watching American news]: I don’t understand??? Things are so bad??? And they set nothing on fire??? How do they expect to fix???
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Congrats my friend!
Leonardo García@LeoGoleoGarcia28 Nov 2020
Group I extensor afferents having access to CPG neuronal circuitry to reset locomotion. I will never forget all the late night science and fun in Mexico city with Hans and Jorge. Candidate Interneurons Mediating the Resetting of the Locomotor Rhythm... sciencedirect.com/science/ar…
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What impact does spinal cord injury have on primary afferent depolarization interneurons and what is the ultimate impact on flexor muscle group I afferents? Excellent new study from @mpcotelab @DrexelNeurobio @Drexel_med_grad Read it now 👉 buff.ly/2IEyDvj
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A causal study of bumetanide on a marker of excitatory-inhibitory balance in the human brain biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Proud to show you my work at @mpcotelab. In this study, I developed a decerebrated rat preparation to investigate the effects of spinal cord injury and step-training on the presynaptic inhibition that was first described by John Eccles et coll. in the 60s. physoc.onlinelibrary.wiley.c…
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