@gserini

Cell adhesion dynamics, angiogenesis and cancer, University of Torino, Candiolo Cancer Institute - All opinions expressed are my own

 Torino, Italy
irccs.org/cell-adhesion-dynamics
Joined January 2010
  • Tweets1.8K
  • Following323
  • Followers490
42Media
Guido Serini retweeted
Cell@CellCellPress20 May 2024
Now online! Ligand binding initiates single-molecule integrin conformational activation dlvr.it/T791P4

Ligand binding initiates single-molecule integrin conformational activation

Viewing integrins in action through single molecules shows that ligand-dependent activation is the predominant factor initiating signaling.

cell.com
1
10
54
15,813
Thrilled to announce our latest research just published in @NatureComms! We investigated how therapy induces therapy resistance via cell state transition and vessel co-option in glioblastoma. (1/11) nature.com/articles/s41467-0… #GBM #btsm #Research

VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance

Nature Communications - In patient with glioblastoma, a major cause of resistance to chemotherapy and radiotherapy is the high degree to intratumoral heterogeneity and cell plasticity. Here, the...

nature.com
8
27
5
100
9,411
Looking very much forward to my visit to @CIBIO_UniTrento of Thu July 20th, meeting and discussing with its scientists
CIBIO - UniTrento@CIBIO_UniTrento18 Jul 2023
We are glad to host "In search of normality: looking for molecular strategies to repair #cancer blood vessels" a seminar by @gserini 🗓️ July, 20th at 2.30pm 🏛️ Room A104, Povo 1 ℹ️ webmagazine.unitn.it/node/11… #blood #bloodtumor
1
3
545
Now with pretty picture added. Delighted to announce the line-up for the 4th Crick International Cancer Conference @TheCrick Great speakers, numerous short talk opportunities, and we've kept prices low. Hope to see you there! crick.ac.uk/whats-on/4th-cri…
51
4
126
26,004
Our paper is now out!! Great and exciting collaborative work. Thank you all. xitter.cf/EmboMolMed/status/1620…
EMBO Mol. Medicine@EmboMolMed1 Feb 2023
Online today! 👉Mutated #AxonGuidance gene #PLXNB2 sustains growth and invasiveness of stem cells isolated from #CancerOfUnknownPrimary By @GiraudoEnrico, L. Tamagnone & colleagues @fpoirccs @unito @Unicatt 🗞️Read #openaccess: doi.org/10.15252/emmm.202216…
2
9
565
Beautiful work from @gserini lab on how integrin antibodies and FAK modulate crosstalk between integrin endocytosis and fibrillar adhesion turnover in ECs. Beautiful imaging and unexpected observations 🤩 life-science-alliance.org/co…

The βI domain promotes active β1 integrin clustering into mature adhesion sites

Modulation of integrin function is required in many physiological and pathological settings, such as angiogenesis and cancer. Integrin allosteric changes, clustering, and trafficking cooperate to...

life-science-alliance.org
1
8
18
Check out our new @biorxivpreprint on counteracting tetraspanner- and BAR domain - nanodomains that results in the formation of stable plasma membrane furrows: biorxiv.org/content/10.1101/…
1
11
28
Super interesting study showing a highly functional role of allosteric ally activated integrin bI/bA domain vs other domains!
LifeScienceAlliance@LSAjournal21 Nov 2022
Replying to @LSAjournal
@adhynamic @gserini @MJ_Humphries @integrintraffic @unito @wtccmr @CoulterBME life-science-alliance.org/co…
1
2
4
Guido Serini retweeted
Serini Lab@adhynamic21 Nov 2022
Replying to @LSAjournal
Very pleased to share our latest effort to functionally disentangle β1 integrin activation and clustering: the extracellular βI domain is key! Great collab with @MJ_Humphries @humphrieslab @integrintraffic @wtccmr
5
16
@adhynamic @gserini @MJ_Humphries @integrintraffic @unito @wtccmr @CoulterBME life-science-alliance.org/co…
2
1
4
Mana et al. show the extracellular headpiece βI domain is involved in conformationally active β1 integrin clustering, fibrillar adhesion formation, incorporation of soluble fibronectin dimers into fibrillar polymers, and extracellular matrix-dependent endothelial cell migration.
2
6
1
11
Very cool piece of literature on #GBM and #TME, great work of integration of knowledge from a large community!! Great job, @AndreasBikfalvi!! Honored to be part of it!
Andreas Bikfalvi@AndreasBikfalvi16 Nov 2022
Our article by the French neuro oncology community has been published today.The printed hard copy version will be out on January. This is a state-of-the-art-article: challenges in glioblastoma research: focus on the tumor microenvironment - ScienceDirect sciencedirect.com/science/ar…
1
2
5
Guido Serini retweeted
Sara Zanivan@ZanivanLab10 Nov 2022
Another fantastic collaboration with @DavidBryantLab! Have a read 👇🏻 #proteomics #MassSpectrometry
This Post is from an account that no longer exists. Learn more
2
10
Our first contribution to the cancer-nerve interaction field is out! We dissect the effect of sensory nerves on TNBC cell migration and metastasis and show that nerves drive changes in gene expression in tumor cells. nature.com/articles/s41523-0…

Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance...

npj Breast Cancer - Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3

nature.com
6
39
9
198
Guido Serini retweeted
Serini Lab@adhynamic2 Nov 2022
📢A #postdoc position is open to join our lab to develop new exciting projects aimed at understanding how axon guidance cues and their receptors regulate #endothelial #celladhesion, #vascular permeability and #cancer cell invasion. Thank you for sharing. – at Turin, Piedmont
7
1
9
📢A #postdoc position is open to join our @adhynamic lab to develop new exciting projects aimed at understanding how axon guidance cues and their receptors regulate #endothelial #celladhesion, #vascular permeability and #cancer cell invasion. Thank you for sharing. – at Turin, Piedmont
27
23
If you are interested in #Autism and #neurodevelopmentaldisorders you may enjoy reading our latest #research on #cdkl5 published with @SpringerNature in @npp_journal here rdcu.be/cTlQN @Telethonitalia @AlberodiGreta @FondazioneCRT @CDKL5USA @ITA_CDKL5_IVLC
2
10
26
Guido Serini retweeted
Fidel Lolo@FidelBio_8323 Oct 2022
Check our last work on the role of caveolae in integrin mechanosensing, thanks to all contributing authors and @CaveoLab members for wonderful support over these years doi.org/10.7554/eLife.82348 @eLife
4
11
1
48
Congratulations Richard O. Hynes, Erkki Ruoslahti, and Timothy A. Springer, 2022 #LaskerAward winners! — “for discoveries concerning the #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease”. @MIT @sbpdiscovery @harvardmed #Lasker2022
12
151
49
501
Delighted to see our review on integrin adhesions published – hope it’s useful and stimulates ideas. Many thanks to @KanchanawongLab for helping drive this, to @NatRevMCB and to the supportive reviewers @johannaivaska, the twitterless Ken Yamada and anonymous others.
Nature Reviews Molecular Cell Biology@NatRevMCB27 Sep 2022
Now Online Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions dlvr.it/SZ4sjs
4
35
2
108
Load more