@grkeele

Postdoc @jacksonlab

 Chapel Hill, NC
gkeele.github.io
Joined September 2010
  • Tweets151
  • Following159
  • Followers136
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Excited to share a new pre-print! Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools biorxiv.org/content/10.1101/…

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central...

Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage—critical for transfusions. To explore genetic influences on RBC...

biorxiv.org
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I'm transitioning away from Twitter to Bluesky (@grkeele.bsky.social). More details there.
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Big thanks to a fantastic scientific village. In particular, Gary Churchill @jacksonlab, Jim Zimring @MedicineUVA, and @dalessandrolab!
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Now out @BloodJournal: Ferroptosis regulates hemolysis in stored RBCs. We identify STEAP3 (p53 target) as a key driver of stored RBC hemolysis by Fe-dependent lipid peroxidation @grkeele @jameszimring @bstockwell Gary Churchill @jacksonlab @GrierPage doi.org/10.1182/blood.202402…
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Blood donors offer a window into "healthy" aging. Now out @AgingCell, we report that arginine metabolism in >13k blood units, 587 sickle cell patients and 525 diversity outbred mice was linked to donor and RBC age, vesiculation and transfusion efficacy doi.org/10.1111/acel.14388

Arginine metabolism is a biomarker of red blood cell and human aging

Reisz et al. examined age-related changes in erythrocyte metabolism using 15,700 specimens from 13,757 individuals across four cohorts, including healthy donors and sickle cell disease patients. The...

onlinelibrary.wiley.com
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Thanks to all involved, Julie A Reisz Haines @travisnemkov @CUAnschutz, @SpitalnikSteven Eldad Hod @Columbia, @jameszimring @UVA, @GrierPage @grkeele @RTI_Intl, Mark Gladwin @UMBaltimore, Mike Busch and Philip Norris @vitalant, Gary Churchill @jacksonlab, Nareg Roubinian @UCSF
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RBCs from poor storing mice make good storing RBCs store poorly as well. A cellular cross-talk, a "good apple, bad apple" effect. Not as flashy as other recent papers I posted, but there is some cool fundamental biology at play here - with @jameszimring dx.doi.org/10.1111/trf.17960

Molecular communication between red blood cells of different phenotypes during blood storage in mice

Background The cellular and molecular changes during red blood cell (RBC) storage that affect posttransfusion recovery (PTR) remain incompletely understood. We have previously reported that RBCs of...

onlinelibrary.wiley.com
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Easy reporting of gene-by-treatment (GxT) or gene-by-environment (GxE) effects on RNA-Seq or other molecular count phenotypes described in a new preprint by my student Yuriko Harigaya with @mikelove : biorxiv.org/content/10.1101/…

Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes

Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which may be highly consequential in biomedicine. An effective approach to identifying G×T signals...

biorxiv.org
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Greg Keele retweeted
Na Cai@caina8928 Jul 2024
Quantgen folks looking for next event after @icqg2024: Registration is open for @GordonConf on Quantgen and genomics (16-21 Feb 2025 in Lucca, Italy), pls register! Program is online, and we have a great speaker lineup grc.org/quantitative-genetic…
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Excited to share our recent study on Biological and Genetic determinants of Red Blood Cell Glycolysis, now out @Cell_Metabolism - cell.com/cell-metabolism/ful…
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What do RBCs without mitochondria do with carnitine? Now out in @BloodJournal. I am finally ready to share the backstory behind this article. It's a story on how we keep reinventing the wheel, and how "old school" biochemistry freaking rocks! ashpublications.org/blood/ar…

Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis...

Key PointsCarnitine pools in stored human and murine RBCs are regulated by genetic polymorphisms in the SLC22A16 and SLC22A5 transporters.Carnitine pools f

ashpublications.org
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Preprint alert: Ferroptosis regulates hemolysis in stored murine and human red blood cells If there is a paper from our lab you will read this year, make it this one. biorxiv.org/content/10.1101/… thread follows - 1/10

Ferroptosis regulates hemolysis in stored murine and human red blood cells

Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. Here, we leveraged a diversity outbred mouse population to map the genetic drivers of fresh/stored RBC...

biorxiv.org
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Chelsea's latest in collaboration with @joselmcfaline and @GarciaLabMS's groups (thanks!) defines differential remodeling of cellular proteomes after epigenetic inhibition! This paper has 'everything': ☑️proteomics ☑️phos ☑️transcriptomics ☑️thermal stability ☑️histone mods
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Greg Keele retweeted
Kathie Sun@SunKat_y21 May 2024
Super excited to introduce the RGC-ME paper nature.com/articles/s41586-0…! We describe the largest catalog of human protein-coding variations to date from exome data of ~1M individuals generated using a single harmonized sequencing and informatics protocol.
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Check out the latest version of our paper on genetic and biological determinants of (RBC) glycolysis. Peer review is definitely making the paper better, and we hope this version will finally be out soon! biorxiv.org/content/10.1101/…

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status...

Mature red blood cells (RBCs) lack mitochondria, and thus exclusively rely on glycolysis to generate adenosine triphosphate (ATP) during aging in vivo and during storage in vitro in the blood bank....

biorxiv.org
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Another interesting discovery from @dalessandrolab: L-carnitine as an important factor in RBC metablism. Supplementation of stored RBCs with L-carnitine as a strategy to improve RBC storage quality? tinyurl.com/yjkmwskc
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#TeamMassSpec We're recruiting postdocs to work on new methods to map proteome remodeling due to chemical perturbations, aging, development, and more! If you're interested, see the job posting: ap.washington.edu/ahr/positi… and some of the lab's projects: schweppelab.org/projects
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Lessons from Blood Donors: your blood not only saves lives, but it is teaching us more about human biology at a scale that just 10y ago was unthinkable. Here we learned something new about genetic and biological factors regulating kynurenine metabolism news.cuanschutz.edu/news-sto…

CU Anschutz Researchers Identify New Biomarker in Quality of Blood Donations

CU Anschutz Researchers Identify New Biomarker in Quality of Blood Donations

news.cuanschutz.edu
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Glad to see our paper, with @xinhe2 @mstephens999 @wescrouse Sheng and Kevin, is out today at @NatureGenet! nature.com/articles/s41588-0…. We developed a new statistical method, causal-TWAS or cTWAS, to reliably identify causal genes in genome-wide association studies (GWAS). 1/n

Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of...

Nature Genetics - Causal-TWAS (cTWAS) is a statistical framework that adjusts for genetic confounders in transcriptome-wide association studies. Application of cTWAS on common traits leads to...

nature.com
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Happy to share two new preprints from our group at @RTI_Intl and collaborators covering DNA methylation and gene expression differences associated with alcohol use disorder in human brain. medrxiv.org/content/10.1101/… medrxiv.org/content/10.1101/… – at North Carolina, USA

Gene expression differences associated with alcohol use disorder in human brain

Excessive alcohol consumption is a leading cause of preventable death worldwide. Neurobiological mechanisms associated with alcohol use disorder (AUD) remain poorly understood. To further understand...

medrxiv.org
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