@gomgomdr

Genetics of lung cancer and melanoma. Tweets are my own.

 Maryland, USA
Joined October 2013
  • Tweets225
  • Following253
  • Followers246
Our preprint on the single-cell lung multiome dataset is out. Led by @ErpingLong & Jinhu Yin and wonderful collaboration with Eun Young Kim and many others @NCIEpiTraining biorxiv.org/cgi/content/shor…
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With this barcode-matched snATAC-seq and snRNA-seq dataset, we mapped target genes from 51 lung cancer GWAS loci using chromatin accessibility-gene expression correlation. We found context-specific gene regulation in epithelial and immune cells underlying many loci
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Congrats @AndrewHaoyu!!
Haoyu Zhang@AndrewHaoyu25 Sep 2023
Our new multi-ancestry PRS paper is now on Nature Genetics: nature.com/articles/s41588-0…! Thanks for the guidance from @nilanjan10c @XihongLin . Also huge thanks to all the amazing collborators: @JiananZhan @Jin_10ustc @JingningZhang35 and all others 1/X.
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Jiyeon Choi retweeted
Diana Withrow@d__with8 Jul 2023
My first ever commentary is out! On a subject I care loads about and with a co-author I deeply admire. I'm aware that many could have written on this, and many more capably than I, so if you are one of those people, I'd love your feedback! aacrjournals.org/cebp/articl…

Cancer Incidence by Race and Immigration Status in Canada: Value of Enhanced Sociodemographic Data...

Abstract. Metrics of cancer burden stratified by race can inform tailored prevention strategies. Examining how these metrics, such as incidence, vary by immigration status can provide insight into...

aacrjournals.org
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I’m happy to share my first first-author paper on #IFNL4 & childhood #BurkittLymphoma. This research provides a baseline that will help characterize IFNL4 among people of African ancestry. liebertpub.com/doi/10.1089/j…

IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa - Francine S. Baker, Jeanny...

Interferon lambda 4 (IFN-λ4) is a novel type-III interferon that can be expressed only by carriers of the genetic variant rs368234815-dG within the first exon o...

journals.sagepub.com
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Great to be a part of this work! The @humancellatlas lung network is really a fantastic group of people!
Lisa Sikkema@SikkemaLisa8 Jun 2023
Today our Human Lung Cell Atlas (HLCA) paper came out in Nature Medicine nature.com/articles/s41591-0…! The HLCA includes 2.4M cells from 486 individuals and 49 datasets. Check out this tweetorial to learn more about how we built it, and how you can use it (1/21)
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Happy to see the Pride flag raised for the first time on NIH campus 🏳️‍⚧️🏳️‍🌈
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Jiyeon Choi retweeted
Minkyo Song@minkyosong31 May 2023
Seeking postdoctoral fellow in autoimmunity and aging! Join our research team today! #postdoc #NIA #aging #autoimmunity #epidemiology training.nih.gov/postdoc_job…
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Wonderful collaborative work of lung adenocarcinoma GWAS in East Asian populations led by Jianxin Shi, Qing Lan, Nat Rothman @NCIEpiTraining @NCIChanock nature.com/articles/s41467-0…

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European...

Nature Communications - Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small...

nature.com
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@kay_michelle721 @HPo10tial
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Notice to all #LDlink users: LDlink has migrated to a new url: ldlink.nih.gov. The old .nci.nih.gov domain will redirect to the new url until further notice. All your favorite #LD tools, plots and downloads will work as before. @NCIEpiTraining @1000genomes @theNCI @NIH
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Check out @ErpingLong's perspective on decoding genetic susceptibility to human diseases via artificial intelligence. Congrats!! @NCIEpiTraining cell.com/cell-genomics/fullt…
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Congrats Thong!!
This Post is from an account that no longer exists. Learn more
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New study in @JNCI_Now presenting cancer death rates in the U.S. by race and ethnicity, disaggregating Asian Americans and Native Hawaiian and Pacific Islanders; and highlighting previously masked disparities. academic.oup.com/jnci/advanc…. Congrats to Anika Haque and our team!
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Incredibly excited to share out latest work using single cell RNA sequencing to identify eQTLs across 38 cell types in primary human lung tissue. biorxiv.org/content/10.1101/… 1/n

Cell type-specific and disease-associated eQTL in the human lung

Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type-specific and context-dep...

biorxiv.org
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We are recruiting a postdoc. Please spread the word! @NCIEpiTraining training.nih.gov/postdoc_job…
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Long read sequencing disentangles germline-somatic interactions at 6p25.1 to improve understanding of #Ewing #sarcoma susceptibility. RREB1, a downstream target of the MAPK pathway, is dysregulated. authors.elsevier.com/a/1gau4… @NCIEpiTraining #NCI_ITEB
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Happening tomorrow at 12PM! Please register for the AJHG journal club! @NCIEpiTraining
Jiyeon Choi@gomgomdr31 Jan 2023
Replying to @ErpingLong
@ErpingLong will present our recent paper at the AJHG February Journal Club on Feb 8th at 12PM (ET). Please register to attend! @NCIEpiTraining #MPRA #melanoma #GWAS
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Jiyeon Choi retweeted
AJHG@AJHGNews23 Nov 2022
New! @gomgomdr & colleagues present a framework to integrate MPRA data and variant scoring to prioritize functional variants & susceptibility genes from GWAS loci bit.ly/3EezPPi
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Our new paper describing MPRA + variant scoring for identifying candidate causal variants and target genes from multiple melanoma GWAS loci is out today sciencedirect.com/science/ar…
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MPRA using both melanoma and cell of origin (melanocyte) context identified cell-type specific functional variants, and a subset of them are supported by tumor-specific TF availability
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Wonderful collaborative work led by @ErpingLong. Congrats to all the authors Jinhu Yin, @kay_michelle721 @tim_myers @kbrowngenetics @NCIChanock @mitchiela @Rohit_thakurrr. @NCIEpiTraining
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