@gloganb

UC Berkeley Organic Chemistry PhD @SarpongGroup from KY. NSF GRFP. BS, GWU, 2020. Sometime baker, guitarist, delusional golfer, and skiing addict.

 Berkeley, CA
gloganbart.github.io
Joined June 2022
  • Tweets26
  • Following137
  • Followers166
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This project was a ton of fun to put together and wouldn’t have been possible without the tremendous efforts of this team. Check out our now-published cheminformatic platform for skeletal edit development prioritization below! bit.ly/3Dq9Mbo

Cheminformatic Analysis of Core-Atom Transformations in Pharmaceutically Relevant Heteroaromatics

Abstract. Heteroaromatics are the basis for many pharmaceuticals. The ability to modify these structures through selective core-atom transformations, or “s

pubs.acs.org
Sarpong Group@SarpongGroup
8 Mar 2025
Congrats to @gloganb & collaborators @lucaskaras1 (@Sigman_Lab) & Reilly & @Charles_chem (Merck) on the publication of our work on a cheminformatic analysis of core-atom transformations in pharmaceutically relevant heteroaromatics in J. Med. Chem. tinyurl.com/42re37pd

Cheminformatic Analysis of Core-Atom Transformations in Pharmaceutically Relevant Heteroaromatics

Abstract. Heteroaromatics are the basis for many pharmaceuticals. The ability to modify these structures through selective core-atom transformations, or “s

pubs.acs.org
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Logan Bartholomew retweeted
Sarpong Group@SarpongGroup
4 Feb 2025
Congrats to @gloganb, @SojungKim20, Yusuke and collaborators @BarnerKowollik, @GileadSciences, @Merck on our indazole to benzimidazole conversion  onlinelibrary.wiley.com/doi/… coordinated with @LeonoriLab  onlinelibrary.wiley.com/doi/…
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Our study detailing indazole-to-benzimidazole phototransposition is out now in @angew_chem together with related work from @LeonoriLab! This has been a fun project to lead, and it’s been my privilege to work with this awesome team. Read below! (1/2) bit.ly/3Q1Uix9
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This work wouldn’t be possible without the tremendous efforts of @SojungKim20, Yusuke Oyamada, @JustinJurczyk at @GileadSciences, @Charles_chem at @Merck, and the @BarnerKowollik group. I can’t thank these collaborators enough. (2/2)
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Logan Bartholomew retweeted
Sojung Kim@SojungKim20
3 Jan 2025
To round out our work on these photomediated ring contractions of saturated heterocycles, I'm excited to share this collaborative story about uncovering interesting enantioselectivity trends in this system, out now in @J_A_C_S!
Sarpong Group@SarpongGroup
3 Jan 2025
Congrats to @SojungKim20, our collaborator Jordan(@Sigman_Lab), our collaborators from Merck and former group members Justin & Yasuki on the publication of our work on understanding the enantioselectivity of our photomediated ring contraction in @J_A_C_S! doi.org/10.1021/jacs.4c13999
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Logan Bartholomew retweeted
Brandon Wright@B_randonwright
20 Nov 2024
The final chapter of my PhD with @SarpongGroup at @UCB_Chemistry is published! Check out our full story of how we approached the synthesis of Daphniphyllum alkaloids inspired by molecular complexity scoring, out now in @J_A_C_S 🎉 pubs.acs.org/doi/10.1021/jac…

Molecular Complexity-Inspired Synthetic Strategies toward the Calyciphylline A‑Type Daphniphyllum...

Abstract. In this report, we detail two distinct synthetic approaches to calyciphylline A-type Daphniphyllum alkaloids himalensine A and daphenylline, whic

pubs.acs.org
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We’re excited to share our quantitative assessment of the potential impact of skeletal edits, now on ChemRxiv! This cheminformatic platform was developed with @lucaskaras1 from @Sigman_Lab and Reilly Eason & @Charles_chem at #MerckChemistry. tinyurl.com/yc4jev9k
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Logan Bartholomew retweeted
Brandon Wright@B_randonwright
9 Sep 2024
Ever thought about quantifying molecular complexity? We wrote a Perspective on how modeling this fascinating concept can lead to new insights in synthetic chemistry. Check it out in @NatRevChem! 🎉 @SarpongGroup nature.com/articles/s41570-0…

Molecular complexity as a driving force for the advancement of organic synthesis

Nature Reviews Chemistry - Quantifying molecular complexity has the potential to enhance retrosynthetic analysis and, thus, aid the development of efficient total syntheses. This Perspective...

nature.com
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Logan Bartholomew retweeted
Paul Sinclair@Paul_P82
15 Jul 2024
My total synthesis of baphicacanthcusine A is out now in @angew_chem. It has been a fascinating journey learning about these unique molecules and I’m really proud to tell this story! onlinelibrary.wiley.com/doi/…

Total Synthesis of (±)‐Baphicacanthcusine A Enabled by Sequential Ring Contractions

An oxidative ring contraction strategy was employed to accomplish the first total synthesis of baphicacanthcusine A. Rapid construction of a key seven-membered-ring intermediate set the stage for a...

onlinelibrary.wiley.com
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Logan Bartholomew retweeted
Sojung Kim@SojungKim20
13 Feb 2024
Our investigation into the photomediated ring contraction of saturated heterocycles is out in @J_A_C_S! Excited to finally share my inaugural 1st author, multi-part story that blends synthesis, mechanistic & wavelength-dependent insight, and computations. tinyurl.com/hccapy9d
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Guilty as charged
Dr. Ortiz, Process Chemistry-er@KCGOrtiz
31 Jan 2024
F*** it. Using "editing" in the title of my next paper. Suzuki Rxn? Editing via C-C Bond Formation and Halogen/Boron Deletion. 3+2? Editing via strategic rearrangement of electrons to form a cycle. Dearomatization of Pyridinium? Editing via the removal of aromaticity.
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Logan Bartholomew retweeted
J. Am. Chem. Soc.@J_A_C_S
30 Jan 2024
14N to 15N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing | Journal of the American Chemical Society @UUtah @UtahChemistry @UCBerkeley @UCB_Chemistry @Sigman_Lab @SarpongGroup #Hetarenes #Skeletal #Editing @TotalSyntheses pubs.acs.org/doi/10.1021/jac…

14N to 15N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing

Abstract. The selective modification of nitrogen heteroaromatics enables the development of new chemical tools and accelerates drug discovery. While method

pubs.acs.org
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Our azine N-isotope exchange is out now in @J_A_C_S! Excited to share this story with a few twists in the @SarpongGroup with the @Sigman_Lab and @Charles_chem from #MerckChemistry. Big thanks to @SamLKraus, @lucaskaras1, and this awesome team. bit.ly/15Nie
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Logan Bartholomew retweeted
Sarpong Group@SarpongGroup
30 Jan 2024
Congrats to @gloganb , @SamLKraus and our collaborators at #Merckchemistry and the @Sigman_Lab on the publication of our work on 14N to 15N exchange in azines in JACS! pubs.acs.org/doi/10.1021/jac…

14N to 15N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing

Abstract. The selective modification of nitrogen heteroaromatics enables the development of new chemical tools and accelerates drug discovery. While method

pubs.acs.org
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Logan Bartholomew retweeted
L.-C. Campeau Ph.D.@DrLCsquare
8 Nov 2023
Great day meeting at @UCB_Chemistry for the #MerckChemistry lecture yesterday. Enjoyed the panel discussion in the AM with students!
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Logan Bartholomew retweeted
Sarpong Group@SarpongGroup
5 Nov 2023
Fourth year @gloganb, placed 2nd in the poster session for his great poster on his recent 14N-to-15N skeletal edit of nitrogen heteroaromatics work. Congrats Logan! We’re so proud of you! 5/5
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Logan Bartholomew retweeted
Andy McNally@AndyMcNally367
2 Nov 2023
15N Incorporation into pyridines via NTf-Zincke imine intermediates now on @ChemRxiv . Congrats to Hillary, David, Marie, Kaila, and Jeff from my lab: tinyurl.com/ytbh3nem See related work from @SarpongGroup @Sigman_Lab/ Smith/Feuillastre-Audisio
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Grateful to have been a part of this awesome team and work with #MerckChemistry and the @Sigman_Lab! Excited to share my new first author paper on an isotopic labeling strategy for nitrogen heteroaromatics using skeletal editing. Check it out on ChemRxiv: rb.gy/990eaq.

14N to 15N Isotopic Exchange of Nitrogen Heteroaromatics through Skeletal Editing | ChemRxiv

The selective modification of nitrogen heteroaromatics enables the development of new chemical tools and accelerates drug discovery. While methods that focus on expanding or contracting the skeletal...

chemrxiv.org
Sarpong Group@SarpongGroup
2 Nov 2023
Swap it out! Congrats @gloganb and @SamLKraus with @Charles_chem (#MerckChemistry) and @lucaskaras1 (@Sigman_Lab) on a 14N-to-15N skeletal edit of nitrogen heteroaromatics (rb.gy/990eaq). Great related works from Joel Smith, Feuillastre/Audisio, and @AndyMcNally367!
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Logan Bartholomew retweeted
J. Am. Chem. Soc.@J_A_C_S
29 Nov 2022
Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion @SarpongGroup @UCBerkeley @UCB_Chemistry @TotalSynthesis @TotalSyntheses #Editing #Pyrimidines #Pyrazoles #Carbon #Deletion pubs.acs.org/doi/10.1021/jac…

Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion

Abstract. A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has been achieved guided by computational analysis. The pyr

pubs.acs.org
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Excited to get this work out! Check out my inaugural first author paper on our method for the conversion of pyrimidine to pyrazole a out now in @J_A_C_S.
Sarpong Group@SarpongGroup
28 Nov 2022
Cut it out! @gloganb and Filippo's publication of a formal deletion of carbon to convert pyrimidines to pyrazoles is out in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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