@LeonoriLab

Group-run account for the Leonori Research Group at RWTH Aachen University. Catalysis. Photoredox. Organic Synthesis.

 Aachen, Germany
leonorigroup.com/
Joined September 2017
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🎓A fully funded PhD position in PHOTOCATALYSIS is available in the Ruffoni Research Group at Kiel University. 📝 📩send: Letter of motivation, CV, MSc and BSc certificates compiled into a single PDF by 25.04.2025 to:📧 [email protected] Subject: PhD-Ruffoni
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Checkout the Front Cover Art for our manuscript: "Photocatalytic Strategy for Decyanative Transformations Enabled by Amine-Ligated Boryl Radical (doi: 10.1021/acs.orglett.4c04701)" in @JOC_OL (@ACSPublications) #MyACSCover
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If you wonder about how to harness innate excited-state reactivity in TM photocatalysis to design new synthetic methods, you can find some guidelines and a rationalization attending to orbitals in this Perspective, just published in @ACSCatalysis : pubs.acs.org/doi/10.1021/acs… (1/3)

Catalysis in the Excited State: Bringing Innate Transition Metal Photochemistry into Play

Abstract. Transition metal catalysis is an indispensable tool for organic synthesis that has been harnessed, modulated, and perfected for many decades by c

pubs.acs.org
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Happy to share our latest results in @angew_chemie on the photochemical permutation of indazoles into benzimidazoles @RWTH Also, make sure you check a related work from the @SarpongGroup also in @angew_chem onlinelibrary.wiley.com/doi/…
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Congratulations to the authors Thiago, Connie, @dbyildiz1, @Martina66310480 and @alexandros4285
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onlinelibrary.wiley.com/doi/…

Phototransposition of Indazoles to Benzimidazoles: Tautomer‐Dependent Reactivity, Wavelength...

Several N2-substituted indazole derivatives efficiently undergo photorearrangement to benzimidazoles with UVB irradiation. Motivated by the difference between the wavelength at which the phototrans...

onlinelibrary.wiley.com
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Join our team! We are seeking passionate PDRA and PhD candidates interested in exploring synthetic methodologies and photochemical transformations. 💡#PhDOpportunity #SyntheticChemistry #Photochemistry #JoinOurTeam🧪
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Discover the latest research of Hairong Lyu @HairongLyu and co-workers highlighting the use of a sp²-sp³ #diboron reagent to access diverse functionalized olefins and acylboranes 🧪 Learn more 👉thieme-connect.com/products/…
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Light-driven method simplifies synthesis of complex heterocycles chemistryworld.com/news/ligh…
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Leonori Lab retweeted
Chem@Chem_CP
22 Nov 2024
Online now: Excited-state protonation and reduction enables the umpolung Birch reduction of naphthalenes dlvr.it/TGL0B9
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Our latest publication in @Chem_CP demonstrates the umpolung Birch-like reduction of naphthalenes by photoexcitation employing a very mild acidic solvent (HFIP) and amine-boranes as reductants with high functional group compatibility ⬇️🔗 cell.com/chem/fulltext/S2451…

Excited-state protonation and reduction enable the umpolung Birch reduction of naphthalenes

The Birch reaction is a key reaction for increasing sp3 content in organic molecules, but it traditionally requires strong reductants. This article presents a new strategy that reverses the nature of...

cell.com
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In this strategy we explore the transient increase of the aromatic basicity after photoexcitation to promote the protonation step, forming an intermediate carbocation which is trapped in situ with Et3N-BH3, by-passing the very low redox potential of aromatics.
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Congratulations to the authors @J_CorpasChem @evariverachao @dr_emarpa @alexandros4285 and the rest of the team including our academic partners and industrial collaborators in Minakem!
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Thrilled to see our first contribution out in @J_A_C_S! @uaitaciano, Roberto, Órla & Ben developed a practical, broad-scope and selective strategy for alkene 1,2-syn-difunctionalization, combining 1,3-DCs with electrochemical radical activation🪡✂️ 📜🔗:pubs.acs.org/doi/10.1021/jac…

General Alkene 1,2-syn-Cyano-Hydroxylation Procedure Via Electrochemical Activation of Isoxazoline...

Abstract. Stereoselective alkene 1,2-difunctionalization is a privileged strategy to access three-dimensional C­(sp3)-rich chiral molecules from readily av

pubs.acs.org
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Excited to share our latest work on chemical permutation, now published in @Nature! Using photochemical conditions, we've developed a method to selectively and predictably transform the structures of thiazoles, isothiazoles, and other azole systems.
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Well done to Baptiste, @MaialenAlonso8, @GiovanniLonardi, Dilara, Connie, @tds_fm, Yan and @alexandros4285. Thank you also to our collaborators Volker, Maria and Martin from @sanofi and Pep from @JanssenUS
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Replying to @LeonoriLab @Nature
nature.com/articles/s41586-0…

Photochemical permutation of thiazoles, isothiazoles and other azoles

Nature - A photochemical method alters thiazole and isothiazole structures predictably that enables selective rearrangements and expanding accessible derivatives, thereby advancing drug and...

nature.com
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Replying to @LeonoriLab @Nature
Building on pioneering studies by Pavlik, Maeda, and Vernin, this research demonstrates a way to reconfigure heteroaromatic structures—enabling one ring system to serve as a starting material for synthesizing another.
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Check out our most recent work for the synthesis of alkynyl boranes from SOMOphilic alkynes as part of the special issue on boryl radical chemistry @Synthesis_1969 @thiemechemistry Congrats to all the team @dr_emarpa @evariverachao and Luka!! thieme-connect.com/products/…
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