@gary_wfoo
 London, Ontario
Joined August 2025
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Paper update! Now online pubs.acs.org/doi/10.1021/acs… at ACS Synthetic Biology @ACSPublications

Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut

Abstract. Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic con

pubs.acs.org
David Edgell@megatev13 Aug 2025
New paper 📢. What happens when @gary_wfoo genetically entangles a thermally-regulated meganuclease and colE9 immunity protein? Ultra-stable biocontainment in the mammalian gut!! biorxiv.org/content/10.1101/…

Genetic entanglement enables ultra-stable biocontainment in the mammalian gut

Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic constructs to treat them is a promising strategy....

biorxiv.org
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Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut pubs.acs.org/doi/10.1021/acs…
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Paper 🚨📢! Adenine methylation in PAM sequence regulates Staph aureus Cas9 activity in bacteria. biorxiv.org/content/10.1101/…. Superstar collab between #DaltonHam @nortnlentivirus

PAM adenine methylation and flanking sequence regulate SaCas9 activity in bacteria

Cas9 nucleases are the effectors of the class 2 type II CRISPR system in bacteria and function to restrict invading DNA. They can also be used with single guide RNAs (sgRNAs) as antimicrobials and...

biorxiv.org
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New paper 📢. What happens when @gary_wfoo genetically entangles a thermally-regulated meganuclease and colE9 immunity protein? Ultra-stable biocontainment in the mammalian gut!! biorxiv.org/content/10.1101/…

Genetic entanglement enables ultra-stable biocontainment in the mammalian gut

Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic constructs to treat them is a promising strategy....

biorxiv.org
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