@for5159

We’re a group of enthusiastic scientists aiming to uncover the dynamic principles of prefrontal processing underlying cognitive flexibility!

for5159.de/
Joined January 2022
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  • Following118
  • Followers169
169Media
Literature highlight of the week: Elston and Wallis used a state-dependent choice task in monkeys to show that the hippocampus relays context-based information via theta waves to the orbitofrontal cortex, which informs valuation and choice nature.com/articles/s41593-0…

Context-dependent decision-making in the primate hippocampal–prefrontal circuit

Nature Neuroscience - The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value...

nature.com
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Our paper published in @NatureComms! We used evidence accumulation model to explain why people make decisions slower after rule switch. There is a reduction in sensory weight, perhaps reflecting the difficulty of switching sensory readout. @luo_tianlin nature.com/articles/s41467-0…
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Literature Highlight of the Week: Almoril-Porras and Calvo et al. demonstrate the necessity of gap junctions in the temperature gradient migration strategies of C. elegans. cell.com/cell/fulltext/S0092…

Configuration of electrical synapses filters sensory information to drive behavioral choices

Sensory information can be differentially processed, enabling similar sensory stimuli to elicit different, context-specific behavioral strategies. This study uncovers a conserved configuration of...

cell.com
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Mugan et al. investigate the effects of environmental complexity on ensemble firing and local field potential in the dmPFC, hippocampus, and dlstriatum of freely moving rats during a foraging task. sciencedirect.com/science/ar…
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Qian et al. explore the dynamic interplay between relevant information and distractor representations in the lateral prefrontal cortex (LPFC) and prearcuate cortex (PAC) of macaque monkeys. jneurosci.org/content/early/…

Working Memory Updating in the Macaque Lateral Prefrontal Cortex

Working memory updating is an important executive process. Here, we study the single-neuron mechanisms involved in updating versus protecting memory from distractors in the macaque prefrontal cortex....

jneurosci.org
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Literature highlight of the week: Chen et al. explore thalamic representation and thalamocortical interactions that contribute to hierarchical cognitive control in humans journals.plos.org/plosbiolog…

The thalamus encodes and updates context representations during hierarchical cognitive control

The cortico-striatal-thalamic circuit is involved in updating cortical task representations, but the role of the thalamus in the context of cognitive flexibility is not well known. This study shows...

journals.plos.org
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Literature highlight of the week: Xu et al. show how robustness and sensitivity coexist in neural networks by analyzing neural dynamics in the monkey prefrontal cortex and using comptational approaches pnas.org/doi/epub/10.1073/pn…
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Our new study is out! biorxiv.org/content/10.1101/… We (@CarlenLab) mapped the mouse PFC using single-unit activity! We recorded ~23,000 neurons across cortical/subcortical regions and profiled spont. firing patterns to reveal what separates the PFC from other brain regions. 1/n

A Prefrontal Cortex Map based on Single Neuron Activity

The intrinsic organization underlying the central cognitive role of the prefrontal cortex (PFC) is poorly understood. The work to date has been dominated by cytoarchitecture as a canvas for studies...

biorxiv.org
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Literature highlight of the week: Van de Maele et al. propose a hierarchical active inference model clarifying how the hippocampal-medial prefrontal cortex circuit solves spatial interaction tasks by bridging physical and task-space maps. nature.com/articles/s41467-0…

A hierarchical active inference model of spatial alternation tasks and the hippocampal-prefrontal...

Nature Communications - How cognitive maps of physical and task space interact when executing cognitive tasks is not fully understood. This paper models how the hippocampal-prefrontal circuits...

nature.com
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Congratulations to the authors @toonvdm @GiovanniPezzulo
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Literature highlight of the week: El-Gaby et al. identify an algorithm that relates medial frontal cortex role in schema formation and sequence memory, by internally organizing mnemonic activity according to an abstract structure shared by different tasks nature.com/articles/s41586-0…
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Congratulations to the authors! @HalassaLab
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Literature highlight of the week: Lam et al. used a decision task with rule reversals in tree shrews and found that relevant thalamic neurons drive prefrontal reconfiguration following a reversal by attributing errors to an environmental change nature.com/articles/s41586-0…

Prefrontal transthalamic uncertainty processing drives flexible switching

Nature - By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive...

nature.com
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