@HalassaLab

Michael Halassa Lab School of Medicine Tufts University

 Boston
halassalab.tufts.edu/
Joined October 2024
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Congrats to Mike for his work @NatMentHealth about which psychosis patient subgroups may benefit most from treatment with muscarinic receptor agonist Cobenfy: nature.com/articles/s44220-0… #schizophrenia #precisionpsychiatry
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Check out this preprint from work with our fantastic colleagues @PalvaLab in Helsinki biorxiv.org/content/10.1101/… Thanks for a great collaboration!

Neuronal oscillations predict un-cued task switching in the Wisconsin card sorting test

Cognitive flexibility is the fundamental ability to rapidly adapt behavior to the environment, even when the contextual rules are implicit and change suddenly. Such type of task switching is commonly...

biorxiv.org
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Congratulations to Norman and Arghya, who have been awarded with this years "Neuroscience Chair's Award for Postdoctoral Research" @TuftsMedSchool honoring their work in the recent discovery of a prefrontal transthalamic role in decision making under uncertainty. #Tupaia, #Nature
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Why Mental Health Treatments Need Algorithmic "Flight Simulators" - read more at #cellreportsmedicine cell.com/cell-reports-medici…

Developing algorithmic psychiatry via multi-level spanning computational models

Halassa et al. introduce algorithmic psychiatry as a framework for mental illness. Using schizophrenia as a case study, they demonstrate how predictive processing integrates neural and cognitive data...

cell.com
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But combining a drug that enhances a neurochemical feature broadly with targeted neurostimulation that augments these benefits to specific circuits could. Pairing such an approach with appropriately-timed behavioral therapy may allow for the brain to be re-wired for recovery.
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The promise is transformative: treatments designed with the whole ‘hardware’ in mind, and guided by interfacing with its ‘software’.
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Congratulations to Arghya for receiving an Early Career Investigator Travel Fellowship Award from the @SOBP Society of Biological Psychiatry!
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Huiwen and Navi are going to present their amazing work at #Cosyne2025. Go check out their work if you get the chance: "A direct link between prefrontal E/I balance and executive dysfunction in schizophrenia" and "A prefrontal to amygdala pathway for adaptive sleep interruption"
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Mengxing received a Post-Doctoral Fellow Award from the Cognitive Neuroscience Society. #CNS2025 Congratulations Mengxing!
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