Neuroscientist, father of daughters, husband to a doctor, son of a shrimp farmer. Handyman. Learning about learning.
Ashburn, VA
Joined August 2011
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Preprint with @jtdudman: Behavior that emerges from classical conditioning improves mice’s policies for reward collection. Dopamine sets the rate of this direct policy learning independent of updating value. 1/n
biorxiv.org/content/10.1101/…
Luke Coddington retweeted
Excited to share out labs’ latest: Congrats to @ReaganLPennock, @fluketc, Xiaohiu Yan, @LindaWadiche & @jwadiche. 'Afferent convergence to a shared population of interneuron AMPA receptors' (2023) Nat Comm. go.nature.com/42iT6ZX. A thread:
Luke Coddington retweeted
The latest installment of @fluketc studies on how dopamine (DA) shapes learning rdcu.be/c3Ibf This was a tricky one; it combines a few ideas that together argue for a new way to understand DA function and account for data that evaded prior models. 1/n
Luke Coddington retweeted
I’m happy to share the first preprint from my lab on my first twitter thread.
biorxiv.org/content/10.1101/…
Luke Coddington retweeted
Excited to share our work addressing the decades-old questions of the role of dopamine in timing and movement initiation, published today in eLife! @yulonglilab @Fangmiao4 @u19teamdope @HMS_Neuro @HarvardMITmdphd @DMSHarvard @TimingForum @PiN_Harvard doi.org/10.7554/eLife.62583
Luke Coddington retweeted
I know. I know. I’m sorry to pile on the bad news. But you have to understand these pogroms happened.
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Luke Coddington retweeted
Come work with us! Help us share the stories of the amazing research and people at Janelia!
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Luke Coddington retweeted
Very excited to have this out! Though this is "only" a perspective piece, I personally feel that this is my most important work yet. 1/15 authors.elsevier.com/c/1dy89…
Luke Coddington retweeted
We have some fun news to share:
2 years, 160 figures, & 22 videos later, our central complex connectome paper is now out @eLife! A pandemic labor of love & true team effort w/ @HannahHaberkern @RFranconville @DanTurnerEvans1
elifesciences.org/articles/6…
Speaking of news...(1/11)
Luke Coddington retweeted
“Most people, I think, don’t even think of the fly as having a brain,” said neuroscientist Vivek Jayaraman. “But, of course, flies lead quite rich lives.” nyti.ms/3jBrThz
Luke Coddington retweeted
A comprehensive blueprint of the central complex and its role in behavior, context, and internal state
A 75-page paper (just the results!) with 75 primary figures (plus supplements!)
[Hulse, Haberkern, Franconville, Turner-Evans]
elifesciences.org/articles/6…
Luke Coddington retweeted
Philosophers often assume that beliefs are *necessarily* responsive to evidence. But the belief that one should change one's beliefs according to evidence is not universal. Many people explicitly reject it. For evidence (& much more), see this great paper: journal.sjdm.org/20/200414/j…
Luke Coddington retweeted
This is why basic research is important! Insights from slice physiology led to our discovery about how to make DBS more long lasting. science.org/doi/10.1126/scie…
Luke Coddington retweeted
Was going to mention that Haith et at study earlier. On similar note - point is that categorically different actions are not selected in BG - lift arm or kick a ball. Goals are selected (cortically) and then a single action planned - BG might bias it. Latter not selection.
Luke Coddington retweeted
This is one functional interpretation but there are many experimental data that do not align with such action selection theory. I think it important to be cautious and avoid presenting what is simply a hypothesis as if it is the definitive truth.
Luke Coddington retweeted
That is indeed one view. On that view I have argued there is very little empirical support for the idea that the key competitive operation (selection) is occurring in striatum. There are several reasons for questioning the empirical evidence for that:
Luke Coddington retweeted
10 Simple Rules For Not Writing Many Papers
1. Have standards
2. Have readable code w/paper
2. Have children
3. Have a hobby (except jigsaw puzzles, that's basically writing a paper)
4. Doomscroll twitter
5. Still doomscrolling?
6. Ruminate about the late anthropocene
7. go to 6
Basal ganglia specifying (human) action
Our new paper out at @eLife w/ @roozbeh_kiani, Arash Fazl, @SoulaMarisol, @Vigi_Katlowitz, Michael Pourfar, and @Alonmogilner! We explored changes in the spike rate of STN neurons as humans alter an ongoing planned action. The results surprised us. 1/7
elifesciences.org/articles/6…
Luke Coddington retweeted
Now that I have 100K followers, I want to talk about #OvarianCancer. Specifically my gritty story. The goal is awareness. I hope you find this narrative informative.
Luke Coddington retweeted
It’s official! Now to get this up and running. Doing research in-line with BRAIN Initiative goals? We are here for you-regardless of location or funding source! Stay tuned for updates…..
